The Venetoclax/Azacitidine Combination Targets the Disease Clone in Acute Myeloid Leukemia, Being Effective and Safe in a Patient with COVID-19.
AML
Venetoclax
Venetoclax/azacitidine combination
t-CMML
targeted-NGS
Journal
Mediterranean journal of hematology and infectious diseases
ISSN: 2035-3006
Titre abrégé: Mediterr J Hematol Infect Dis
Pays: Italy
ID NLM: 101530512
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
03
2022
accepted:
15
04
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
27
5
2022
Statut:
epublish
Résumé
The addition of Venetoclax (VEN) to Hypomethylating agents (HMAs) significantly improves the probability of complete remission and prolongs survival in patients with Acute Myeloid Leukemia (AML) when compared to HMA alone. However, the mutated clone composition may impact the probability of response and its duration. Here, we describe the molecular profile of a patient with AML rapidly evolved from a previous therapy-related-Chronic MyeloMonocytic Leukemia, who achieved safely complete remission after treatment with the VEN/Azacitidine combination, even in the presence of SARS-COVID-2 infection. The targeted NGS analysis showed that the VEN/AZA combination led to the eradication of the
Identifiants
pubmed: 35615323
doi: 10.4084/MJHID.2022.041
pii: mjhid-14-1-e2022041
pmc: PMC9083951
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e2022041Déclaration de conflit d'intérêts
Competing interests: The authors declare no conflict of Interest. Competing Interests. MTV received honoraria from Celgene/BMS and Abbvie.
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