Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis.
COVID-19
IFN-β
apoptosis
efferocytosis
macrophage reprogramming
resolution of inflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
01
2022
accepted:
22
03
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
The resolution of inflammation is a temporally and spatially coordinated process that in its innate manifestations, primarily involves neutrophils and macrophages. The shutdown of infection or injury-induced acute inflammation requires termination of neutrophil accumulation within the affected sites, neutrophil demise, and clearance by phagocytes (efferocytosis), such as tissue-resident and monocyte-derived macrophages. This must be followed by macrophage reprogramming from the inflammatory to reparative and consequently resolution-promoting phenotypes and the production of resolution-promoting lipid and protein mediators that limit responses in various cell types and promote tissue repair and return to homeostatic architecture and function. Recent studies suggest that these events, and macrophage reprogramming to pro-resolving phenotypes in particular, are not only important in the acute setting, but might be paramount in limiting chronic inflammation, autoimmunity, and various uncontrolled cytokine-driven pathologies. The SARS-CoV-2 (COVID-19) pandemic has caused a worldwide health and economic crisis. Severe COVID-19 cases that lead to high morbidity are tightly associated with an exuberant cytokine storm that seems to trigger shock-like pathologies, leading to vascular and multiorgan failures. In other cases, the cytokine storm can lead to diffuse alveolar damage that results in acute respiratory distress syndrome (ARDS) and lung failure. Here, we address recent advances on effectors in the resolution of inflammation and discuss how pro-resolution mechanisms with particular emphasis on macrophage reprogramming, might be harnessed to limit the universal COVID-19 health threat.
Identifiants
pubmed: 35615359
doi: 10.3389/fimmu.2022.863449
pmc: PMC9124752
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
863449Subventions
Organisme : CIHR
ID : MOP-102619
Pays : Canada
Informations de copyright
Copyright © 2022 Silberberg, Filep and Ariel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Annu Rev Pathol. 2018 Jan 24;13:27-49
pubmed: 28934563
Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1913-22
pubmed: 23650399
J Exp Med. 2005 Mar 7;201(5):713-22
pubmed: 15753205
J Leukoc Biol. 2012 Jan;91(1):127-36
pubmed: 22028334
Cell Death Differ. 2007 May;14(5):1040-9
pubmed: 17290285
J Immunol. 2020 Jul 1;205(1):12-19
pubmed: 32423917
J Immunol Res. 2017;2017:5150678
pubmed: 29410971
Am J Physiol Cell Physiol. 2020 Sep 1;319(3):C510-C532
pubmed: 32667864
J Immunol. 1999 Mar 15;162(6):3639-46
pubmed: 10092825
Eur J Immunol. 2011 Feb;41(2):366-79
pubmed: 21268007
Immunity. 2009 Feb 20;30(2):180-92
pubmed: 19239902
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14983-8
pubmed: 22927428
Int J Mol Sci. 2018 Mar 03;19(3):
pubmed: 29510522
N Engl J Med. 2006 Sep 7;355(10):1018-28
pubmed: 16908486
Molecules. 2018 Jul 27;23(8):
pubmed: 30060484
Nat Rev Immunol. 2020 Apr;20(4):254-267
pubmed: 31822793
Best Pract Res Clin Rheumatol. 2021 Mar;35(1):101661
pubmed: 33526325
Blood. 2007 Dec 1;110(12):4077-85
pubmed: 17690256
Immunity. 2014 Mar 20;40(3):315-27
pubmed: 24656045
J Immunol. 2007 Nov 1;179(9):5728-37
pubmed: 17947645
Nat Rev Immunol. 2011 Oct 10;11(11):762-74
pubmed: 21984070
J Clin Invest. 1998 Feb 15;101(4):890-8
pubmed: 9466984
Blood. 1997 Nov 1;90(9):3356-63
pubmed: 9345017
Blood. 2006 Sep 15;108(6):1821-9
pubmed: 16705092
Immunity. 2009 Aug 21;31(2):245-58
pubmed: 19646905
J Neuropathol Exp Neurol. 2006 Feb;65(2):124-41
pubmed: 16462204
Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63
pubmed: 24355989
J Immunol. 2017 Aug 15;199(4):1393-1404
pubmed: 28674178
J Exp Med. 2015 Jul 27;212(8):1203-17
pubmed: 26195725
Oncotarget. 2017 Nov 28;8(68):112297-112312
pubmed: 29348826
Front Immunol. 2013 Jan 08;3:414
pubmed: 23316199
J Immunol. 2011 Jan 1;186(1):53-61
pubmed: 21106854
Viruses. 2019 Dec 20;12(1):
pubmed: 31861926
Nat Rev Immunol. 2017 Apr;17(4):233-247
pubmed: 28192415
Int Immunopharmacol. 2020 Sep;86:106749
pubmed: 32645632
Annu Rev Immunol. 2015;33:643-75
pubmed: 25861979
Immunity. 2014 May 15;40(5):720-33
pubmed: 24792913
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Trends Neurosci. 1996 Aug;19(8):312-8
pubmed: 8843599
Immunity. 2018 Oct 16;49(4):666-677.e6
pubmed: 30291029
Cell Res. 2021 Mar;31(3):272-290
pubmed: 33473155
Emerg Infect Dis. 2005 Mar;11(3):411-6
pubmed: 15757556
Prostaglandins Other Lipid Mediat. 2013 Dec;107:85-94
pubmed: 23954858
Science. 2012 Apr 6;336(6077):86-90
pubmed: 22442384
Cell Tissue Res. 2012 Feb;347(2):443-55
pubmed: 22281685
Blood. 2016 Jun 30;127(26):3431-8
pubmed: 27136946
J Immunol Res. 2016;2016:8239258
pubmed: 26885535
Science. 2017 Feb 17;355(6326):748-752
pubmed: 28059714
Apoptosis. 2020 Aug;25(7-8):558-573
pubmed: 32564202
Annu Rev Cell Dev Biol. 2017 Oct 6;33:127-144
pubmed: 28613937
J Leukoc Biol. 2004 May;75(5):828-35
pubmed: 14742636
J Allergy Clin Immunol. 2013 Sep;132(3):515-525
pubmed: 23993353
J Exp Med. 2006 Mar 20;203(3):583-97
pubmed: 16492803
Immunity. 2003 Jul;19(1):71-82
pubmed: 12871640
Emerg Microbes Infect. 2020 Dec;9(1):1123-1130
pubmed: 32475230
Annu Rev Pharmacol Toxicol. 2001;41:367-401
pubmed: 11264462
Nat Rev Immunol. 2008 Dec;8(12):958-69
pubmed: 19029990
Front Immunol. 2013 Apr 08;4:85
pubmed: 23580000
Neurology. 2014 Jul 15;83(3):278-86
pubmed: 24871874
Nat Immunol. 2006 Nov;7(11):1209-16
pubmed: 17013391
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926098
J Leukoc Biol. 2011 Sep;90(3):413-24
pubmed: 21628329
J Clin Med. 2020 Sep 11;9(9):
pubmed: 32932930
Cell Death Dis. 2014 Mar 06;5:e1102
pubmed: 24603330
Nat Rev Immunol. 2020 Oct;20(10):587-588
pubmed: 32778829
J Leukoc Biol. 2013 Oct;94(4):595-601
pubmed: 23625199
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
Science. 2011 Jun 10;332(6035):1284-8
pubmed: 21566158
Nat Commun. 2019 Aug 2;10(1):3471
pubmed: 31375662
Nat Med. 2005 Jun;11(6):666-71
pubmed: 15895074
Nat Immunol. 2021 Jan;22(1):32-40
pubmed: 33277638
Front Immunol. 2020 Mar 31;11:553
pubmed: 32296442
J Immunol. 2011 Jun 15;186(12):7144-55
pubmed: 21593381
Mol Biol Cell. 2014 Nov 1;25(21):3330-41
pubmed: 25165138
Science. 2008 Aug 15;321(5891):970-4
pubmed: 18703742
Nat Rev Immunol. 2014 Jun;14(6):392-404
pubmed: 24854589
Sci Transl Med. 2014 Jan 15;6(219):219ra7
pubmed: 24431111
Nat Immunol. 2005 Dec;6(12):1191-7
pubmed: 16369558
Sci Immunol. 2019 Jan 25;4(31):
pubmed: 30679199
Science. 2010 Nov 5;330(6005):841-5
pubmed: 20966214
FASEB J. 2001 Dec;15(14):2736-8
pubmed: 11687510
Trends Immunol. 2006 May;27(5):244-50
pubmed: 16584921
Trends Immunol. 2015 Oct;36(10):651-662
pubmed: 26431942
Nat Commun. 2020 Feb 13;11(1):878
pubmed: 32054845
Immunity. 2020 Jul 14;53(1):19-25
pubmed: 32610079
Immunity. 2014 May 15;40(5):642-56
pubmed: 24837101
Immunity. 2007 Dec;27(6):952-64
pubmed: 18093541
Circ Res. 2008 Aug 15;103(4):352-9
pubmed: 18617697
Cell. 2010 Mar 5;140(5):619-30
pubmed: 20211132
Immunol Lett. 2011 Mar 30;135(1-2):88-95
pubmed: 20937308
J Immunother Cancer. 2018 Jun 11;6(1):51
pubmed: 29891009
Mol Aspects Med. 2017 Dec;58:114-129
pubmed: 28336292
J Neuroimmunol. 2019 Jul 15;332:16-30
pubmed: 30928868
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
Virol Sin. 2020 Jun;35(3):256-258
pubmed: 32034638
Nature. 2012 Apr 25;484(7395):524-8
pubmed: 22538616
JAMA. 2020 Aug 11;324(6):539
pubmed: 32780125
J Clin Invest. 1989 Mar;83(3):865-75
pubmed: 2921324
FASEB J. 2012 Sep;26(9):3891-900
pubmed: 22651933
Front Immunol. 2020 Apr 24;11:743
pubmed: 32395119
Nat Rev Immunol. 2002 Dec;2(12):965-75
pubmed: 12461569
J Neurol. 2022 Feb;269(2):541-576
pubmed: 34386902
J Leukoc Biol. 2006 May;79(5):896-903
pubmed: 16641135
J Cell Biochem. 2019 Aug;120(8):12604-12617
pubmed: 30825233
Cell Mol Immunol. 2017 May;14(5):423-431
pubmed: 26435067
Front Biosci. 2008 Jan 01;13:453-61
pubmed: 17981560
J Immunol. 2005 Mar 15;174(6):3727-33
pubmed: 15749912
Rev Neurosci. 2020 Dec 07;32(2):219-234
pubmed: 33550782
J Leukoc Biol. 2019 Aug;106(2):345-358
pubmed: 30576000
Nat Rev Rheumatol. 2010 May;6(5):280-9
pubmed: 20431553
Eur J Immunol. 2016 Jul;46(7):1592-9
pubmed: 27139187
Immunol Rev. 2010 Jul;236:28-40
pubmed: 20636806
Clin Rheumatol. 2020 Jul;39(7):2085-2094
pubmed: 32474885
Cancers (Basel). 2019 Sep 24;11(10):
pubmed: 31554253
FASEB J. 2020 Aug;34(8):9843-9853
pubmed: 32588493
Front Immunol. 2020 Mar 31;11:405
pubmed: 32296415
Annu Rev Immunol. 2018 Apr 26;36:489-517
pubmed: 29400998
Essays Biochem. 2003;39:105-17
pubmed: 14585077
Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7971-7980
pubmed: 32205444
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Trends Immunol. 2007 Apr;28(4):176-83
pubmed: 17337246
PLoS Pathog. 2009 May;5(5):e1000461
pubmed: 19478887
Cell. 2013 Mar 28;153(1):112-25
pubmed: 23477864
Nat Med. 2006 Sep;12(9):1056-64
pubmed: 16951685
Bull World Health Organ. 1972;46(6):845-52
pubmed: 4538544
Biochim Biophys Acta. 1994 Apr 14;1212(1):1-25
pubmed: 8155718
Autoimmun Rev. 2020 Jun;19(6):102537
pubmed: 32251717
J Immunol. 2000 Jun 15;164(12):6166-73
pubmed: 10843666
J Immunol. 2013 Jan 15;190(2):565-77
pubmed: 23241891
Blood. 2016 May 5;127(18):2173-81
pubmed: 27002116
Ann Neurol. 2020 Jul;88(1):1-11
pubmed: 32506549
Immunity. 2019 May 21;50(5):1149-1162
pubmed: 31117011
Neurocrit Care. 2021 Jun;34(3):1062-1071
pubmed: 32661794
J Toxicol Environ Health B Crit Rev. 2008 Jan;11(1):1-15
pubmed: 18176884
Ageing Res Rev. 2015 Sep;23(Pt A):90-100
pubmed: 25862945
Science. 2009 Mar 27;323(5922):1722-5
pubmed: 19264983
Nat Cell Biol. 2019 Dec;21(12):1532-1543
pubmed: 31792382
Am J Respir Crit Care Med. 2009 Aug 15;180(4):311-9
pubmed: 19483113
Nat Rev Immunol. 2020 Oct;20(10):585-586
pubmed: 32788708
Thorax. 2010 Aug;65(8):684-9
pubmed: 20685741
Nat Neurosci. 2005 Jun;8(6):752-8
pubmed: 15895084
Immunology. 2021 Jan;162(1):30-43
pubmed: 32935333
J Neuropathol Exp Neurol. 2004 Mar;63(3):262-73
pubmed: 15055450
J Immunol. 2015 Jun 1;194(11):5472-5487
pubmed: 25917098
Annu Rev Biochem. 2011;80:1055-87
pubmed: 21456965
Front Immunol. 2012 Jan 31;3:4
pubmed: 22566890
Clin Neurol Neurosurg. 2020 Jul;194:105921
pubmed: 32422545
Ann Med. 2016;48(4):256-67
pubmed: 27018196
Cell Stem Cell. 2017 Jun 1;20(6):735-736
pubmed: 28575684
Nature. 2015 Feb 26;518(7540):547-51
pubmed: 25470051
Front Immunol. 2019 Feb 01;10:119
pubmed: 30774631
Nat Rev Immunol. 2017 Jun;17(6):349-362
pubmed: 28436425
Sci Rep. 2016 Aug 24;6:32092
pubmed: 27554194
Cell Death Differ. 2016 Jun;23(6):927-37
pubmed: 26868912
Semin Immunol. 2005 Aug;17(4):313-8
pubmed: 15955712
Science. 1994 Jun 24;264(5167):1918-21
pubmed: 8009221
J Exp Med. 2019 Feb 4;216(2):384-406
pubmed: 30674564
Trends Immunol. 2011 Apr;32(4):157-64
pubmed: 21334975
Nat Commun. 2018 Nov 21;9(1):4903
pubmed: 30464171
Theranostics. 2021 Jan 1;11(3):1059-1078
pubmed: 33391521
Nature. 2013 Apr 25;496(7446):445-55
pubmed: 23619691
Rev Med Virol. 2020 Nov;30(6):1-9
pubmed: 32845568
Curr Opin Immunol. 2013 Oct;25(5):629-38
pubmed: 24012250
Nat Med. 2009 Nov;15(11):1266-72
pubmed: 19838202
Cells. 2020 Oct 27;9(11):
pubmed: 33120941
Nat Commun. 2019 Sep 25;10(1):4353
pubmed: 31554795
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
Nature. 2016 Nov 24;539(7630):570-574
pubmed: 27820945
FASEB J. 2003 Apr;17(6):652-9
pubmed: 12665478
Nat Immunol. 2016 Jan;17(1):9-17
pubmed: 26681457
Eur Heart J Suppl. 2021 Oct 08;23(Suppl E):E95-E98
pubmed: 34650364
Front Immunol. 2021 Jun 04;12:679498
pubmed: 34149716
Mol Immunol. 2019 Oct;114:299-311
pubmed: 31421540
N Engl J Med. 2013 Apr 18;368(16):1509-1518
pubmed: 23527958
J Exp Med. 2011 Mar 14;208(3):417-20
pubmed: 21357740
J Leukoc Biol. 1996 Jun;59(6):769-74
pubmed: 8691059
Front Cell Dev Biol. 2020 Dec 08;8:613733
pubmed: 33364241
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Curr Neurol Neurosci Rep. 2021 Feb 14;21(3):9
pubmed: 33586020
Nat Rev Immunol. 2011 Oct 10;11(11):738-49
pubmed: 21984069
Ann Neurol. 2004 May;55(5):627-38
pubmed: 15122702
Front Immunol. 2018 Nov 13;9:2586
pubmed: 30542342
J Clin Invest. 2018 Oct 1;128(10):4297-4312
pubmed: 29990310
Clin Sci (Lond). 2016 Apr;130(8):601-12
pubmed: 26785675
Adv Immunol. 2013;120:69-103
pubmed: 24070381
JCI Insight. 2020 Jul 9;5(13):
pubmed: 32501293
Eur J Immunol. 2016 Jul;46(7):1583-6
pubmed: 27345468
Circ Res. 2018 Jan 5;122(1):113-127
pubmed: 29301844
Nat Rev Mol Cell Biol. 2007 May;8(5):405-13
pubmed: 17377525