HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein.
CREB protein
HIV
mitochondria
neurodegeneration
rolipram
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2021
accepted:
31
03
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
27
5
2022
Statut:
epublish
Résumé
HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming. This led to decreased ATP levels, lower mitochondrial DNA copy numbers, and loss of mitochondria
Identifiants
pubmed: 35615594
doi: 10.3389/fnagi.2022.811481
pmc: PMC9124804
doi:
Types de publication
Journal Article
Langues
eng
Pagination
811481Subventions
Organisme : NIDA NIH HHS
ID : R01 DA052209
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH087332
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104131
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105330
Pays : United States
Informations de copyright
Copyright © 2022 Shrestha, Santerre, Allen, Arjona, Merali, Mukerjee, Chitrala, Park, Bagashev, Bui, Eugenin, Merali, Kaul, Chin and Sawaya.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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