Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats.

Administration, Oral Animals Dogs Feces Heterocyclic Compounds, 2-Ring Injections, Intravenous Pyrimidines Rats Tissue Distribution
Absorption and excretion (ADME) autoradiography blood–brain barrier distribution metabolism pharmacokinetics preclinical rats sGC stimulator

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
May 2022
Historique:
pubmed: 27 5 2022
medline: 31 8 2022
entrez: 26 5 2022
Statut: ppublish

Résumé

Vericiguat is a soluble guanylate cyclase stimulator. The pharmacokinetics, absorption, metabolism, and excretion properties of vericiguat in rats and dogs and the distribution in rats are reported. [

Identifiants

DOI: 10.1080/00498254.2022.2082899 PMID: 35616579
pubmed: 35616579
doi: 10.1080/00498254.2022.2082899
doi:

Substances chimiques

Heterocyclic Compounds, 2-Ring 0
Pyrimidines 0
vericiguat LV66ADM269

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

453-462

Auteurs

Wiebke Janssen (W)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Thomas Schwarz (T)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Ulf Bütehorn (U)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Wolfram Steinke (W)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.
Pharmacokinetic Imaging Consulting & Autoradiography Services, 58553 Halver, Germany.

Steffen Sandmann (S)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Dieter Lang (D)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Armin Kern (A)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Frank Hucke (F)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

Michael Gerisch (M)

Bayer Aktiengesellschaft, DMPK, 42096 Wuppertal, Germany.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Eucaryotes › Animaux › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections veineuses › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Pharmacokinetics and mass balance of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Pharmacokinetics and mass balance of...