Erectile Dysfunction in Patients with Multiple Chronic Conditions: A Cross- Sectional Study.
Charlson comorbidity index
Erectile dysfunction
comorbidities
cross-sectional study
type 2 diabetes
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
11
2021
revised:
29
03
2022
accepted:
04
04
2022
pubmed:
27
5
2022
medline:
17
3
2023
entrez:
26
5
2022
Statut:
ppublish
Résumé
The prevalence of erectile dysfunction (ED) rises with the number and severity of chronic diseases. This cross-sectional study assessed the frequency and severity of ED in patients with multiple chronic conditions. The 5-item International Index of Erectile Function questionnaire (IIEF-5) was used to diagnose and classify ED. The Charlson Comorbidity Index (CCI) was used to assess the burden of chronic comorbidity. The primary outcome was to assess the ED frequency according to CCI severity. The secondary outcomes included the assessment of the correlation between 1) IIEF-5 and total testosterone (TT), 2) CCI and TT, and 3) IIEF-5 and CCI. Lastly, the CCI and modified CCI (mCCI) performances were compared with each other. The overall frequency of ED increased along with the CCI score severity: 45% for CCI=0; 95% for CCI=1; 91% for CCI=2; 99% for CCI≥3 (p<.0001). CCI correlated negatively with TT levels and IIEF-5 score (r=-0.34 and -0.44; p<.0001). Compared to the CCI, a novel proposed mCCI performs well. The frequency and severity of ED are relevant in outpatients with sexual complaints and those with chronic comorbidities. Despite limitations, mCCI may be considered a reliable tool to assess the overall burden of multiple chronic conditions in patients with comorbidities. ED is a reliable proxy of overall male health. Further studies are needed to confirm this potential application.
Sections du résumé
BACKGROUND
BACKGROUND
The prevalence of erectile dysfunction (ED) rises with the number and severity of chronic diseases.
AIMS
OBJECTIVE
This cross-sectional study assessed the frequency and severity of ED in patients with multiple chronic conditions.
METHODS
METHODS
The 5-item International Index of Erectile Function questionnaire (IIEF-5) was used to diagnose and classify ED. The Charlson Comorbidity Index (CCI) was used to assess the burden of chronic comorbidity. The primary outcome was to assess the ED frequency according to CCI severity. The secondary outcomes included the assessment of the correlation between 1) IIEF-5 and total testosterone (TT), 2) CCI and TT, and 3) IIEF-5 and CCI. Lastly, the CCI and modified CCI (mCCI) performances were compared with each other.
RESULTS
RESULTS
The overall frequency of ED increased along with the CCI score severity: 45% for CCI=0; 95% for CCI=1; 91% for CCI=2; 99% for CCI≥3 (p<.0001). CCI correlated negatively with TT levels and IIEF-5 score (r=-0.34 and -0.44; p<.0001). Compared to the CCI, a novel proposed mCCI performs well.
DISCUSSION
CONCLUSIONS
The frequency and severity of ED are relevant in outpatients with sexual complaints and those with chronic comorbidities. Despite limitations, mCCI may be considered a reliable tool to assess the overall burden of multiple chronic conditions in patients with comorbidities.
CONCLUSION
CONCLUSIONS
ED is a reliable proxy of overall male health. Further studies are needed to confirm this potential application.
Identifiants
pubmed: 35616670
pii: EMIDDT-EPUB-123862
doi: 10.2174/1871530322666220523130212
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
396-404Informations de copyright
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