A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
27 05 2022
27 05 2022
Historique:
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
31
5
2022
Statut:
ppublish
Résumé
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
Identifiants
pubmed: 35617386
doi: 10.1126/science.abm1703
pmc: PMC9282941
mid: NIHMS1816496
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1006-1012Subventions
Organisme : NHLBI NIH HHS
ID : F30 HL157066
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL148523
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL155844
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL161249
Pays : United States
Commentaires et corrections
Type : CommentIn
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