Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis.

Humans COVID-19 HIV Infections / complications Comorbidity Databases, Factual World Health Organization
AIDS COVID-19 HIV Meta-analysis Mortality Systematic review

Journal

Journal of infection and public health
ISSN: 1876-035X
Titre abrégé: J Infect Public Health
Pays: England
ID NLM: 101487384

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 04 03 2022
revised: 27 04 2022
accepted: 10 05 2022
medline: 23 10 2023
pubmed: 27 5 2022
entrez: 26 5 2022
Statut: ppublish

Résumé

The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger's test was employed to determine the risk of bias. A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86-1.32). The between-studies heterogeneity was substantial (I Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection.

Sections du résumé

BACKGROUND BACKGROUND
The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality.
METHODS METHODS
We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger's test was employed to determine the risk of bias.
RESULTS RESULTS
A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86-1.32). The between-studies heterogeneity was substantial (I
CONCLUSION CONCLUSIONS
Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection.

Identifiants

DOI: 10.1016/j.jiph.2022.05.006 PMID: 35617829 PMC: PMC9110010
pubmed: 35617829
pii: S1876-0341(22)00126-5
doi: 10.1016/j.jiph.2022.05.006
pmc: PMC9110010
pii:
doi:

Types de publication

Meta-Analysis Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

654-661

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Competing interests The authors declare no competing interests.

Auteurs

Tafadzwa Dzinamarira (T)

School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa; ICAP at Columbia University, Harare, Zimbabwe. Electronic address: u19395419@up.ac.za.

Grant Murewanhema (G)

Unit of Obstetrics and Gynaecology, Department of Primary Health Care Sciences, Faculty of Medicine and Health Sciences, University of Zimbabwe, Zimbabwe.

Itai Chitungo (I)

Faculty of Medicine, College of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

Bernard Ngara (B)

Faculty of Medicine, College of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

Sphamandla Josias Nkambule (SJ)

Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban 4001, South Africa.

Roda Madziva (R)

University of Nottingham, UK.

Helena Herrera (H)

University of Portsmouth, UK.

Solomon Mukwenha (S)

ICAP at Columbia University, Harare, Zimbabwe.

Diego F Cuadros (DF)

University of Cincinnati, USA.

Patrick Gad Iradukunda (PG)

London School of Hygiene and Tropical Medicine, University of London, London, UK.

Moreblessing Mashora (M)

Department of Public Health, Mount Kenya University, Kigali, Rwanda.

Nigel Tungwarara (N)

Department of Health Studies, University of South Africa, South Africa.

Gallican Nshogoza Rwibasira (GN)

Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.

Godfrey Musuka (G)

ICAP at Columbia University, Harare, Zimbabwe.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Risk of mortality in HIV-infected COVID-19...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Risk of mortality in HIV-infected COVID-19...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Risk of mortality in HIV-infected COVID-19...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Risk of mortality in HIV-infected COVID-19...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Risk of mortality in HIV-infected COVID-19...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Agences internationales › Nations Unies › Organisation mondiale de la santé › Risk of mortality in HIV-infected COVID-19...