Dysbiosis of gut microbiota and intestinal damage in mice induced by a single intravenous exposure to CdTe quantum dots at low concentration.
CdTe
gut microbiota
intestine
quantum dots
toxicity
Journal
Journal of applied toxicology : JAT
ISSN: 1099-1263
Titre abrégé: J Appl Toxicol
Pays: England
ID NLM: 8109495
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
23
04
2022
received:
07
10
2021
accepted:
24
05
2022
pubmed:
27
5
2022
medline:
18
10
2022
entrez:
26
5
2022
Statut:
ppublish
Résumé
Although quantum dots (QDs) have shown great potential for various biomedical applications, their potential toxicity still needs to be comprehensively investigated. Previous studies showed that intravenous exposure of CdTe QDs at low concentration did not lead to obvious in vivo toxicity in the long term. However, the influence of CdTe QDs on the gut microbiota and the intestine is still unknown. Here, we explored whether single intravenous injection of CdTe QDs at low concentration can affect the gut microbiota and intestine of mice in short term. The results showed that CdTe QDs caused an imbalance of gut microbiota, especially the rapid increase in Lactobacillus on day 1 post-treatment. Meanwhile, the intestine exhibited the promotion of oxidative stress, inflammatory response, and hemorrhaging on days 5 and 15. These results demonstrate that the gut microbiota and the intestine are very sensitive to the toxicity of low-concentration CdTe QDs. This study provides further insight and method for the biosafety evaluation of nanomaterials.
Substances chimiques
Cadmium Compounds
0
Tellurium
NQA0O090ZJ
cadmium telluride
STG188WO13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1757-1765Subventions
Organisme : Natural Science Key Fund for Colleges and Universities in Jiangsu Province
ID : 19KJB310010
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20191382
Organisme : Key Research and Development Program of Jiangsu Province
ID : BE2018732
Organisme : National Key Research and Development Program of China
ID : 2017YFA0205302
Informations de copyright
© 2022 John Wiley & Sons, Ltd.
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