The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
03
12
2021
accepted:
13
05
2022
revised:
21
04
2022
pubmed:
27
5
2022
medline:
3
12
2022
entrez:
26
5
2022
Statut:
ppublish
Résumé
Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.
Identifiants
pubmed: 35618748
doi: 10.1038/s41372-022-01415-4
pii: 10.1038/s41372-022-01415-4
pmc: PMC9699898
mid: NIHMS1836979
doi:
Substances chimiques
Betamethasone
9842X06Q6M
Banques de données
ClinicalTrials.gov
['NCT01222247']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1615-1621Subventions
Organisme : NICHD NIH HHS
ID : UG1 HD027869
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD087230
Pays : United States
Organisme : NICHD NIH HHS
ID : U10HD036801
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD027915
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD034208
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1HD027904
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD040485
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD027904
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD036801
Pays : United States
Organisme : NICHD NIH HHS
ID : U24 HD036801
Pays : United States
Investigateurs
Abbot R Laptook
(AR)
Lina Chalak
(L)
Athina Pappas
(A)
Alexis Davis
(A)
Pablo J Sanchez
(PJ)
Krisa P Van Meurs
(KP)
William Oh
(W)
Seetha Shankaran
(S)
Angelita M Hensman
(AM)
Scott McDonald
(S)
Abhik Das
(A)
Ronald N Goldberg
(RN)
Namasivayam Ambalavanan
(N)
Rosemary D Higgins
(RD)
Dwight J Rouse
(DJ)
Cynthia Gyamfi-Bannerman
(C)
Elizabeth A Thom
(EA)
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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