Mechanisms of Suppression of Epinephrine Production in Rats by Low-Dose Developmental Exposure to DDT.
adrenal gland
endocrine disruptor
epinephrine
mitochondria
tyrosine hydroxylase
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
15
10
2021
pubmed:
27
5
2022
medline:
9
6
2022
entrez:
26
5
2022
Statut:
ppublish
Résumé
We studied the mechanisms underlying decreased production of epinephrine by adrenal glands in rats developmentally exposed to endocrine disruptor DDT was performed on the basis of assessment of morphology, fine structure, and function of the adrenal medulla and medullary cells. It was found that the main mechanisms of disruptive action of DDT leading to a decrease in epinephrine secretion into systemic circulation are a decrease in the growth rate of the adrenal medulla, a decrease in the number of mitochondria in adrenal cells, especially under the outer cytoplasmic membrane, destructive changes in mitochondria, and a progressive decrease in the synthesis of tyrosine hydroxylase. The decrease in the number of mitochondria and suppression tyrosine hydroxylase synthesis in adrenal cells predominate during the pubertal period, while slowdown of the growth of the adrenal medulla and progressive decrease in the synthesis of tyrosine hydroxylase seem to be the most evident mechanisms after puberty.
Identifiants
pubmed: 35618967
doi: 10.1007/s10517-022-05503-5
pii: 10.1007/s10517-022-05503-5
doi:
Substances chimiques
DDT
CIW5S16655
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-113Informations de copyright
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.
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