Associations between circadian misalignment and telomere length in BD: an actigraphy study.
Actigraphy
Bipolar disorder
Circadian
Eveningness
Morningness
Telomere
Journal
International journal of bipolar disorders
ISSN: 2194-7511
Titre abrégé: Int J Bipolar Disord
Pays: Germany
ID NLM: 101622983
Informations de publication
Date de publication:
27 May 2022
27 May 2022
Historique:
received:
28
02
2022
accepted:
25
04
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
27
5
2022
Statut:
epublish
Résumé
Life expectancy is significantly decreased in bipolar disorder (BD). This is associated with accelerated cellular aging which can be estimated by telomere length (TL). However, specific determinants of shorter TL in BD are under-explored. This study examines whether circadian misalignment (i.e. mismatch between preferred and actual phase of circadian activity rhythms) is associated with shorter TL in BD. Euthymic individuals with BD (n = 101) undertook 21 consecutive days of actigraphy recording and completed the Composite Scale of Morningness (CSM) to assess phase preference for activities (chronotype). Polymerase chain reaction was used to measure TL in blood. Cluster analysis identified circadian aligned/misaligned subgroups as defined by preferred (CSM score) and actual phases of activity (actigraphically determined onset of active and inactive periods). We tested for any associations between TL and clusters, with adjustments for between-cluster differences in socio-demographic and illness factors. We identified three clusters: an "Aligned Morning" cluster (n = 31) with preferred and actual timing of activity in the morning, an "Aligned Evening" cluster (n = 37) with preferred and actual timing of activity in the evening and a "Misaligned" cluster (n = 32) with an evening chronotype, but an earlier objective onset of active periods. After adjustment for confounders, we found that TL was significantly associated with circadian misalignment and older age. Circadian misalignment may partly explain shorter TL in BD and could contribute to accelerated aging in these individuals.
Sections du résumé
BACKGROUND
BACKGROUND
Life expectancy is significantly decreased in bipolar disorder (BD). This is associated with accelerated cellular aging which can be estimated by telomere length (TL). However, specific determinants of shorter TL in BD are under-explored. This study examines whether circadian misalignment (i.e. mismatch between preferred and actual phase of circadian activity rhythms) is associated with shorter TL in BD.
METHODS
METHODS
Euthymic individuals with BD (n = 101) undertook 21 consecutive days of actigraphy recording and completed the Composite Scale of Morningness (CSM) to assess phase preference for activities (chronotype). Polymerase chain reaction was used to measure TL in blood. Cluster analysis identified circadian aligned/misaligned subgroups as defined by preferred (CSM score) and actual phases of activity (actigraphically determined onset of active and inactive periods). We tested for any associations between TL and clusters, with adjustments for between-cluster differences in socio-demographic and illness factors.
RESULTS
RESULTS
We identified three clusters: an "Aligned Morning" cluster (n = 31) with preferred and actual timing of activity in the morning, an "Aligned Evening" cluster (n = 37) with preferred and actual timing of activity in the evening and a "Misaligned" cluster (n = 32) with an evening chronotype, but an earlier objective onset of active periods. After adjustment for confounders, we found that TL was significantly associated with circadian misalignment and older age.
CONCLUSIONS
CONCLUSIONS
Circadian misalignment may partly explain shorter TL in BD and could contribute to accelerated aging in these individuals.
Identifiants
pubmed: 35619042
doi: 10.1186/s40345-022-00260-w
pii: 10.1186/s40345-022-00260-w
pmc: PMC9135941
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14Subventions
Organisme : Fondation FondaMental
ID : Prix Face
Organisme : Fondation FondaMental
ID : Prix Marcel Dassault
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : C0829
Organisme : Assistance Publique - Hôpitaux de Paris
ID : GAN12
Informations de copyright
© 2022. The Author(s).
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