Brain Under Fatigue - Can Perceived Fatigability in Multiple Sclerosis Be Seen on the Level of Functional Brain Network Architecture?
ALFF/fALFF
fatigue
functional network (FN)
multiple sclerosis (MS)
resting-state fMRI (rs-fMRI)
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
01
2022
accepted:
28
03
2022
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
Fatigue is one of the most common symptoms of multiple sclerosis (MS), significantly affecting the functioning of the patients. However, the neural underpinnings of physical and mental fatigue in MS are still vague. The aim of our study was to investigate the functional architecture of resting-state networks associated with fatigue in patients with MS. The sum of 107 high-functioning patients underwent a resting-state scanning session and filled out the 9-item Fatigue Severity Scale (FSS). Based on the FSS score, we identified patients with different levels of fatigue using the cluster analysis. The low-fatigue group consisted of Two-sample Current study revealed significant functional network (FN) architecture between-group differences associated with fatigue. Present results suggest the higher level of fatigue is related to deficits in awareness as well as higher interoceptive awareness and nociception.
Sections du résumé
Background
UNASSIGNED
Fatigue is one of the most common symptoms of multiple sclerosis (MS), significantly affecting the functioning of the patients. However, the neural underpinnings of physical and mental fatigue in MS are still vague. The aim of our study was to investigate the functional architecture of resting-state networks associated with fatigue in patients with MS.
Methods
UNASSIGNED
The sum of 107 high-functioning patients underwent a resting-state scanning session and filled out the 9-item Fatigue Severity Scale (FSS). Based on the FSS score, we identified patients with different levels of fatigue using the cluster analysis. The low-fatigue group consisted of
Results
UNASSIGNED
Two-sample
Conclusion
UNASSIGNED
Current study revealed significant functional network (FN) architecture between-group differences associated with fatigue. Present results suggest the higher level of fatigue is related to deficits in awareness as well as higher interoceptive awareness and nociception.
Identifiants
pubmed: 35620154
doi: 10.3389/fnhum.2022.852981
pmc: PMC9128356
doi:
Types de publication
Journal Article
Langues
eng
Pagination
852981Informations de copyright
Copyright © 2022 Sobczak, Bohaterewicz, Ceglarek, Zyrkowska, Fafrowicz, Slowik, Wnuk, Marona, Nowak, Zur-Wyrozumska and Marek.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Neurosci. 2011 Jul 27;12(9):539-44
pubmed: 21792218
Front Neurol. 2018 Aug 20;9:690
pubmed: 30177910
Mult Scler. 2014 Jul;20(8):1050-7
pubmed: 24326671
J Neurol Sci. 2006 Jun 15;245(1-2):93-8
pubmed: 16626753
J Neurosci Rural Pract. 2013 Jul;4(3):278-82
pubmed: 24250159
J Neurol Sci. 2012 Dec 15;323(1-2):9-15
pubmed: 22935407
Eur J Neurol. 2017 Jan;24(1):27-36
pubmed: 27633185
Mult Scler. 2000 Apr;6(2):131-6
pubmed: 10773860
Mult Scler. 2002 Oct;8(5):359-65
pubmed: 12356200
Mult Scler. 2019 Apr;25(4):554-564
pubmed: 29464981
Neurorehabil Neural Repair. 2021 Nov;35(11):960-973
pubmed: 34583577
J Neurol Sci. 2011 May 15;304(1-2):127-31
pubmed: 21349545
Nat Rev Dis Primers. 2018 Nov 8;4(1):43
pubmed: 30410033
Swiss Med Wkly. 2007 Sep 8;137(35-36):496-501
pubmed: 17990136
Diagnostics (Basel). 2020 Nov 10;10(11):
pubmed: 33182742
Neuroimage. 2014 Jul 1;94:385-395
pubmed: 24361662
Br J Clin Psychol. 1993 Sep;32(3):357-64
pubmed: 8251968
Brain Struct Funct. 2016 Apr;221(3):1555-71
pubmed: 25613901
Neurology. 2001 Jan 23;56(2):215-9
pubmed: 11160958
Postgrad Med. 2019 Sep;131(7):523-532
pubmed: 31478421
Nat Neurosci. 2015 Apr;18(4):499-500
pubmed: 25751532
PLoS One. 2013 Nov 01;8(11):e78811
pubmed: 24223850
Neuroinformatics. 2016 Jul;14(3):339-51
pubmed: 27075850
Neuroimage. 2002 Mar;15(3):559-67
pubmed: 11848698
Mult Scler. 2022 Apr;28(4):502-511
pubmed: 32880515
Mult Scler. 2009 Mar;15(3):337-44
pubmed: 18987107
J Neurosci Methods. 2008 Jul 15;172(1):137-41
pubmed: 18501969
Eur Radiol. 2016 Feb;26(2):515-23
pubmed: 26026721
Neurorehabil Neural Repair. 2008 Jan-Feb;22(1):91-100
pubmed: 17409388
Brain. 1955;78(4):445-70
pubmed: 13293263
Neurosci Lett. 2016 Feb 12;614:105-11
pubmed: 26797652
Rehabil Psychol. 2012 May;57(2):159-66
pubmed: 22686554
Mult Scler. 2011 Apr;17(4):411-22
pubmed: 21239414
Parkinsons Dis. 2016;2016:2835945
pubmed: 26925292
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Mult Scler. 2010 Oct;16(10):1220-8
pubmed: 20670981
Mult Scler. 2011 Sep;17(9):1041-54
pubmed: 21467189
Arch Neurol. 1989 Oct;46(10):1121-3
pubmed: 2803071
Brain. 2014 Jul;137(Pt 7):2052-64
pubmed: 24771519
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Mult Scler. 2014 Mar;20(3):338-48
pubmed: 23828871
Hum Brain Mapp. 2014 Nov;35(11):5486-99
pubmed: 24916602
Nat Neurosci. 2000 Feb;3(2):184-90
pubmed: 10649575
Mult Scler. 2021 Apr;27(4):559-567
pubmed: 33283582
Hum Brain Mapp. 2005 Mar;24(3):216-28
pubmed: 15543553
Behav Res Ther. 2021 Feb;137:103464
pubmed: 31780252
Front Neurosci. 2014 Jul 01;8:167
pubmed: 25071425
Brain. 2002 Jul;125(Pt 7):1607-15
pubmed: 12077009
Mult Scler. 2018 Nov;24(13):1696-1705
pubmed: 28911257
Neuroimage. 2017 May 15;152:437-449
pubmed: 28167349
Neuroradiology. 2020 Jun;62(6):693-704
pubmed: 32189024
J Neurosci. 2017 Jan 11;37(2):281-290
pubmed: 28077708
Sleep. 2010 Aug;33(8):1061-7
pubmed: 20815187
Neuroimage. 2017 Apr 15;150:213-229
pubmed: 28213118
Mult Scler. 2016 Nov;22(13):1695-1708
pubmed: 26838014
J Psychosom Res. 2017 Sep;100:1-7
pubmed: 28789787
AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1180-7
pubmed: 23348760
Front Neurol. 2016 Aug 02;7:122
pubmed: 27531990
BMC Neurol. 2014 Mar 25;14:58
pubmed: 24666846
PLoS One. 2014 Jul 07;9(7):e101198
pubmed: 24999807
Acta Neurol Belg. 2013 Dec;113(4):411-4
pubmed: 23616230
Radiology. 2014 Jun;271(3):814-21
pubmed: 24484065
Front Immunol. 2019 Jan 10;9:3116
pubmed: 30687321
Mult Scler. 2003 Jun;9(3):219-27
pubmed: 12814166
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
Noro Psikiyatr Ars. 2018;55(Suppl 1):S69-S75
pubmed: 30692861
Mult Scler Relat Disord. 2019 Jun;31:101-105
pubmed: 30954931
Acta Neurol Scand. 1995 Nov;92(5):353-5
pubmed: 8610485
J Neurol Sci. 2013 Aug 15;331(1-2):102-7
pubmed: 23791482
IBRO Rep. 2018 Sep 27;5:60-66
pubmed: 30310873
J Neurosci Methods. 2015 Apr 30;245:107-15
pubmed: 25725332
Trends Cogn Sci. 2013 Dec;17(12):666-82
pubmed: 24238796
Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17763-7
pubmed: 20837517
Neuroimage. 2013 Aug 1;76:183-201
pubmed: 23499792
Trends Cogn Sci. 2017 May;21(5):385-401
pubmed: 28372878
PLoS One. 2016 Jan 04;11(1):e0146080
pubmed: 26727514
Brain Imaging Behav. 2016 Dec;10(4):1117-1126
pubmed: 26553579