CRISPER/CAS System, a Novel Tool of Targeted Therapy of Drug-Resistant Lung Cancer.
CRISPR/CAS
Cancer
Genetic modification
Lung
Journal
Advanced pharmaceutical bulletin
ISSN: 2228-5881
Titre abrégé: Adv Pharm Bull
Pays: Iran
ID NLM: 101578021
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
13
12
2020
revised:
04
03
2021
accepted:
31
03
2021
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
ppublish
Résumé
Lung cancer (LC) is the most common cause of cancer-related death worldwide. Patients with LC are usually diagnosed at advanced phases. Five-year survival rate in LC patients is approximately 16%. Despite decades of research on LC treatments, clinical outcomes are still very poor, necessitating to develop novel technologies to manage the disease. Considering the role of genetic and epigenetic changes in oncogenes and tumor-suppressor genes in cancer progression, gene therapy provides a hot spot in cancer treatment research. Gene therapy offers less side effects compared to conventional methods such as chemotherapy. Unlike the traditional approaches of gene therapy that have temporary effects, using genetic modification tools can offer persistent cure. Over the past a few years, many studies have effectively used the CRISPR-Cas9 approach to modify gene expression in cells. This system is applied to induce site-specific mutagenesis and epigenetic modifications and regulate gene expression. In this review, we discuss recent applications of the CRISPR-Cas9 technology in treating LC.
Identifiants
pubmed: 35620343
doi: 10.34172/apb.2022.027
pmc: PMC9106967
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
262-273Informations de copyright
©2022 The Authors.
Références
Cancer Treat Rev. 2019 Jan;72:15-27
pubmed: 30445271
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):513-521
pubmed: 31871154
Cell. 2015 Aug 13;162(4):900-10
pubmed: 26276636
J Cell Biochem. 2018 Nov 28;:
pubmed: 30485511
Mol Cancer Res. 2019 Feb;17(2):594-603
pubmed: 30409919
Nat Biotechnol. 2017 Jan;35(1):31-34
pubmed: 27918548
Clin Chest Med. 2011 Dec;32(4):703-40
pubmed: 22054881
Biochem Biophys Res Commun. 2013 Jul 5;436(3):486-90
pubmed: 23751349
EMBO Mol Med. 2016 Jan 08;8(2):83-5
pubmed: 26747090
Nature. 2014 Dec 18;516(7531):428-31
pubmed: 25337879
N Engl J Med. 2009 Sep 3;361(10):947-57
pubmed: 19692680
J Thorac Oncol. 2013 Apr;8(4):408-14
pubmed: 23392229
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15644-9
pubmed: 23940360
Genomics. 2020 May;112(3):2615-2622
pubmed: 32068121
Nature. 2014 Oct 16;514(7522):380-4
pubmed: 25119044
Toxicol Appl Pharmacol. 2017 Sep 1;330:30-39
pubmed: 28688920
Front Oncol. 2019 Apr 16;9:264
pubmed: 31058078
Nat Chem Biol. 2016 Jan;12(1):22-8
pubmed: 26595461
Nat Biotechnol. 2014 Apr;32(4):347-55
pubmed: 24584096
Allergy Asthma Proc. 2002 Mar-Apr;23(2):103-8
pubmed: 12001788
Nat Med. 2015 Jun;21(6):560-2
pubmed: 25939061
J Control Release. 2017 Nov 28;266:17-26
pubmed: 28911805
Eur J Cancer. 2012 Jun;48(9):1299-311
pubmed: 22464348
Int J Mol Sci. 2019 Mar 31;20(7):
pubmed: 30935143
Cell Metab. 2019 Feb 5;29(2):285-302.e7
pubmed: 30415923
Lung Cancer (Auckl). 2010 May 08;1:23-36
pubmed: 28210104
Mol Cell. 2017 Feb 16;65(4):618-630.e7
pubmed: 28065598
J Int Med Res. 2013 Dec;41(6):1779-87
pubmed: 24265329
Clin Cancer Res. 2009 Apr 15;15(8):2666-74
pubmed: 19351763
Transl Lung Cancer Res. 2014 Dec;3(6):370-2
pubmed: 25806323
Nat Biotechnol. 2014 Sep;32(9):941-6
pubmed: 24952903
Nat Commun. 2018 Feb 5;9(1):502
pubmed: 29402884
Adv Exp Med Biol. 2016;893:1-19
pubmed: 26667336
Clin Lung Cancer. 2016 Sep;17(5):e141-e149
pubmed: 26791542
Int J Clin Exp Pathol. 2015 Jun 01;8(6):6312-22
pubmed: 26261507
Cancer Res Treat. 2019 Jan;51(1):408-412
pubmed: 29807405
Medicine (Baltimore). 2017 Feb;96(6):e6087
pubmed: 28178168
Transl Lung Cancer Res. 2016 Feb;5(1):26-38
pubmed: 26958491
Interdiscip Sci. 2018 Jun;10(2):455-465
pubmed: 29644494
Oncotarget. 2015 Sep 15;6(27):23764-75
pubmed: 26156017
Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39
pubmed: 25322323
Science. 2004 Jun 4;304(5676):1497-500
pubmed: 15118125
Lab Invest. 2018 Jul;98(7):968-976
pubmed: 29748615
Oncotarget. 2017 May 30;8(22):36331-36338
pubmed: 28422737
Cell. 2013 Jul 18;154(2):442-51
pubmed: 23849981
J Clin Oncol. 2014 Jan 10;32(2):121-8
pubmed: 24323028
Surg Oncol Clin N Am. 2016 Jul;25(3):439-45
pubmed: 27261907
Cancer Gene Ther. 2015 Nov;22(11):509-17
pubmed: 26494554
Clin Cancer Res. 2019 Feb 15;25(4):1302-1317
pubmed: 30429198
Mol Ther. 2016 Mar;24(3):636-44
pubmed: 26658966
J Cell Biochem. 2019 Nov;120(11):19172-19185
pubmed: 31271232
Cancers (Basel). 2018 Jul 27;10(8):
pubmed: 30060526
PLoS One. 2017 Jan 24;12(1):e0170445
pubmed: 28118392
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3978-E3986
pubmed: 29632194
Elife. 2017 Mar 24;6:
pubmed: 28337968
Cell. 2014 Oct 9;159(2):440-55
pubmed: 25263330
Nature. 2007 Aug 2;448(7153):561-6
pubmed: 17625570
Science. 2016 Jan 1;351(6268):84-8
pubmed: 26628643
Mol Biol Rep. 2019 Jun;46(3):3557-3569
pubmed: 30941642
Nature. 2014 Dec 18;516(7531):423-7
pubmed: 25337876
Semin Cancer Biol. 2019 Apr;55:106-119
pubmed: 29673923
Curr Issues Mol Biol. 2018;28:47-68
pubmed: 29428910
Cancer Sci. 2016 Jun;107(6):713-20
pubmed: 27027665
Nat Rev Clin Oncol. 2011 Jan;8(1):25-37
pubmed: 20975744
Cell Cycle. 2007 Feb 1;6(3):274-85
pubmed: 17264681
Nature. 2017 Oct 19;550(7676):407-410
pubmed: 28931002
Nat Rev Cancer. 2015 Jul;15(7):387-95
pubmed: 26040603
J Clin Med. 2016 Mar 09;5(3):
pubmed: 27005669
Genome Biol. 2015 Nov 24;16:257
pubmed: 26596280
Avicenna J Med Biotechnol. 2018 Apr-Jun;10(2):98-104
pubmed: 29849986
Clin Cancer Res. 2003 Nov 1;9(14):5055-67
pubmed: 14613982
Cell. 2014 Oct 23;159(3):647-61
pubmed: 25307932
Biomedicine (Taipei). 2017 Dec;7(4):23
pubmed: 29130448
J Clin Invest. 2014 Oct;124(10):4154-61
pubmed: 25271723
Cytokine. 2018 Nov;111:567-570
pubmed: 29884309
Mol Cell. 2016 Aug 4;63(3):526-38
pubmed: 27453044
Nat Nanotechnol. 2018 Dec;13(12):1182-1190
pubmed: 30177807
Genes Chromosomes Cancer. 2019 Apr;58(4):233-243
pubmed: 30382614
Biochim Biophys Acta. 2016 Dec;1866(2):197-207
pubmed: 27641687
Lancet Oncol. 2011 Oct;12(11):1004-12
pubmed: 21933749
Nat Rev Clin Oncol. 2019 May;16(5):281-295
pubmed: 30664678
Nat Med. 2016 Oct;22(10):1108-1119
pubmed: 27643638
Nat Rev Cancer. 2007 Oct;7(10):778-90
pubmed: 17882278
J Thorac Dis. 2013 Oct;5 Suppl 5:S479-90
pubmed: 24163741