Identifying Features of Cardiac Disease Phenotypes Based on Mechanical Function in a Catecholaminergic Polymorphic Ventricular Tachycardia Model.
2D cell culture
DIC
contraction rate
disease model
iPSC-cardiomyocytes
mechanical strain
microcontact printing
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
02
2022
accepted:
12
04
2022
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by an arrhythmogenic mechanism involving disruption of calcium handling. This genetic disease can lead to sudden death in children and young adults during physical or emotional stress. Prior CPVT studies have focused on calcium handling, but mechanical functionality has rarely been investigated
Identifiants
pubmed: 35620470
doi: 10.3389/fbioe.2022.873531
pii: 873531
pmc: PMC9127198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
873531Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL055438
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139738
Pays : United States
Informations de copyright
Copyright © 2022 Stempien, Josvai, de Lange, Hernandez, Notbohm, Kamp, Valdivia, Eckhardt, Maginot, Ralphe and Crone.
Déclaration de conflit d'intérêts
TK was a consultant for Cellular Dynamics International, a stem cell biotechnology company. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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