Administration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids.
drug delivery
gene delivery
partial liquid ventilation
perfluorochemicals
pulmonary
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
02
2022
accepted:
31
03
2022
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
The present review is a historical perspective of methodology and applications using inert liquids for respiratory support and as a vehicle to deliver biological agents to the respiratory system. As such, the background of using oxygenated inert liquids (considered a drug when used in the lungs) opposed to an oxygen-nitrogen gas mixture for respiratory support is presented. The properties of these inert liquids and the mechanisms of gas exchange and lung function alterations using this technology are described. In addition, published preclinical and clinical trial results are discussed with respect to treatment modalities for respiratory diseases. Finally, this forward-looking review provides a comprehensive overview of potential methods for administration of drugs/gene products to the respiratory system and potential biomedical applications.
Identifiants
pubmed: 35620598
doi: 10.3389/fphys.2022.871893
pii: 871893
pmc: PMC9127416
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
871893Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL151760
Pays : United States
Informations de copyright
Copyright © 2022 Alapati and Shaffer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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