A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component.
autophagy
effectors
immunity
ubiquitination
xenophagy
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
04 07 2022
04 07 2022
Historique:
revised:
15
04
2022
received:
03
12
2021
accepted:
21
04
2022
pubmed:
28
5
2022
medline:
8
7
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
Beyond its role in cellular homeostasis, autophagy plays anti- and promicrobial roles in host-microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense-related autophagy in plant-bacteria interactions.
Identifiants
pubmed: 35620914
doi: 10.15252/embj.2021110352
pmc: PMC9251887
doi:
Substances chimiques
Virulence Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e110352Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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