The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy.

Animals Mice Autophagy Colitis / chemically induced Inflammasomes / metabolism Inflammation / metabolism Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Intracellular Signaling Peptides and Proteins / metabolism
Autophagy receptor CCDC50 NLRP3 inflammasome immune homeostasis inflammatory bowel disease

Journal

Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188

Informations de publication

Date de publication:
01 2023
Historique:
pubmed: 28 5 2022
medline: 30 12 2022
entrez: 27 5 2022
Statut: ppublish

Résumé

The assembly of the NLRP3 inflammasome can be initiated by a wide range of stimuli including exogenous infection as well as endogenous damage. Therefore, the tight regulation of the NLRP3 inflammasome is crucial for the host to resist microbial invasion and maintain homeostasis. Our recent work has identified a negative regulator of NLRP3-mediated inflammation, namely CCDC50 (coiled-coil domain containing protein 50). CCDC50 can be induced by NLRP3 agonists and then functions as a macroautophagy/autophagy cargo receptor to recognize K63-polyubiquitinated NLRP3 and deliver it to MAP1LC3/LC3-conjugated phagophores for degradation. CCDC50 inhibits the polymerization of NLRP3 and the recruitment of PYCARD/ASC, consequently suppressing the assembly of inflammasomes.

Identifiants

DOI: 10.1080/15548627.2022.2080957 PMID: 35620989 PMC: PMC9809959
pubmed: 35620989
doi: 10.1080/15548627.2022.2080957
pmc: PMC9809959
doi:

Substances chimiques

Inflammasomes 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
Nlrp3 protein, mouse 0
Intracellular Signaling Peptides and Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

365-366

Références

EMBO Rep. 2022 May 4;23(5):e54453
pubmed: 35343634

Auteurs

Panpan Hou (P)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Tian Tian (T)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Penghui Jia (P)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Yuxin Lin (Y)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Zibo Li (Z)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Yicheng Wang (Y)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Yu Ye (Y)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Chunmei Li (C)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

Deyin Guo (D)

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › The regulation of NLRP3 inflammasome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › The regulation of NLRP3 inflammasome...