Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle-Aged Population.
arterial stiffness
brain magnetic resonance imaging
vascular properties
white matter hyperintensity
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
07 06 2022
07 06 2022
Historique:
pubmed:
28
5
2022
medline:
9
6
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
Background The periventricular white matter is more sensitive to the systemic hemodynamic alterations than the deep white matter because of differences in its vascular structure and systemic circulation relationship. We hypothesize that periventricular white matter hyperintensity (PVWMH) volume shows greater association than deep white matter hyperintensity (DWMH) volume with vascular properties (VPs) reflecting arterial stiffness and cardiovascular remodeling, indicators of the systemic circulation. Methods and Results A total of 426 participants (age, 59.0±6.1 years; 57.5% women; and 39.7% Black race) in the Genetic Study of Atherosclerosis Risk who were aged ≥50 years and had brain magnetic resonance imaging were studied. VPs included pulse pressure, hypertensive response to exercise, diastolic brachial artery diameter, diastolic common carotid artery diameter, common carotid artery distensibility coefficient, and left ventricular function. The relative associations of VPs with PVWMH and DWMH as multiple measures within the same individual were determined using multilevel linear models. We also determined if age modified the differences in VPs associations with PVWMH and DWMH. Our findings indicated that, within the same subject, PVWMH volume had greater association than DWMH volume with pulse pressure (
Identifiants
pubmed: 35621212
doi: 10.1161/JAHA.121.024606
pmc: PMC9238713
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e024606Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL105897
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS112459
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Références
J Am Heart Assoc. 2020 Aug 18;9(16):e016883
pubmed: 32783485
Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H822-8
pubmed: 15345491
Nat Rev Cardiol. 2018 Feb;15(2):97-105
pubmed: 29022570
Stroke Vasc Neurol. 2017 Jun 8;2(3):108-117
pubmed: 28989801
Stroke. 2012 Oct;43(10):2631-6
pubmed: 22923446
J Cardiovasc Med (Hagerstown). 2014 Nov;15(11):788-96
pubmed: 24838039
Hypertension. 2013 Jun;61(6):1360-83
pubmed: 23608661
Neurology. 2015 May 12;84(19):1920-6
pubmed: 25862800
JAMA. 2012 Sep 5;308(9):875-81
pubmed: 22948697
Clin Hypertens. 2016 Jul 26;22:17
pubmed: 27468357
Nucl Med Rev Cent East Eur. 2014;17(2):70-4
pubmed: 25088105
Stroke Vasc Neurol. 2016 Oct 25;1(3):83-92
pubmed: 28959468
Hypertension. 2014 Aug;64(2):253-8
pubmed: 24842921
Mech Ageing Dev. 2020 Jul;189:111267
pubmed: 32473170
ESC Heart Fail. 2020 Oct 20;:
pubmed: 33084248
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Curr Cardiol Rep. 2016 Dec;18(12):123
pubmed: 27796861
Hypertension. 2010 May;55(5):1075-85
pubmed: 20351340
QJM. 2002 Feb;95(2):67-74
pubmed: 11861952
Circ Cardiovasc Imaging. 2014 May;7(3):446-53
pubmed: 24577355
Stroke. 1994 Feb;25(2):318-27
pubmed: 8303738
Biol Psychiatry. 2008 Aug 15;64(4):273-80
pubmed: 18471801
Blood Press. 2009;18(3):130-4
pubmed: 19462313
Front Cardiovasc Med. 2020 Feb 04;7:6
pubmed: 32118044
AJNR Am J Neuroradiol. 2018 Dec;39(12):2243-2248
pubmed: 30442693
AJR Am J Roentgenol. 1987 Aug;149(2):351-6
pubmed: 3496763
Curr Hypertens Rep. 2015 Feb;17(2):12
pubmed: 25687599
Circulation. 1994 Feb;89(2):615-22
pubmed: 8313549
Circ Cardiovasc Imaging. 2016 Jul;9(7):
pubmed: 27353852
Cerebrovasc Dis. 2021;50(1):100-107
pubmed: 33279889
Circulation. 1999 Aug 31;100(9):951-7
pubmed: 10468526
Neuroepidemiology. 2011;36(4):252-7
pubmed: 21677450
Stroke. 2020 Jul;51(7):2111-2121
pubmed: 32517579
Acta Pharmacol Sin. 2010 Oct;31(10):1267-76
pubmed: 20802505
Neuroimage. 2010 Jan 15;49(2):1524-35
pubmed: 19766196
J Clin Hypertens (Greenwich). 2020 Nov;22(11):1960-1967
pubmed: 32986936
Clin Chem. 2000 Nov;46(11):1762-72
pubmed: 11067811
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1034-1043
pubmed: 31875700
Atherosclerosis. 2018 Jan;268:92-98
pubmed: 29195110
Dement Geriatr Cogn Disord. 1998 Jul;9 Suppl 1:2-5
pubmed: 9716237
Hypertension. 2018 Jul;72(1):85-92
pubmed: 29785959
Stroke. 2021 Aug;52(8):2594-2600
pubmed: 34000829
J Neurosci Methods. 2007 Sep 15;165(1):111-21
pubmed: 17604116
Hypertension. 2018 Sep;72(3):549-558
pubmed: 30354762
Stroke. 2016 Feb;47(2):554-60
pubmed: 26742799