Characterization of Dosage Levels for In Ovo Administration of Innate Immune Stimulants for Prevention of Yolk Sac Infection in Chicks.
CpG
chickens
innate immune stimulants
poly I:C
yolk sac infection
Journal
Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127
Informations de publication
Date de publication:
22 Apr 2022
22 Apr 2022
Historique:
received:
10
03
2022
revised:
16
04
2022
accepted:
21
04
2022
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
Innate immune stimulants, especially toll-like receptor (TLR) ligands and agonists, are the main players in the initiation of innate immunity and have been widely studied as alternatives to antibiotics to control infection. In the present study, we characterized the dosage levels of various innate immune stimulants, including unmethylated cytosine-phosphate-guanosine dinucleotide -containing oligodeoxynucleotides (CpG ODN), polyinosinic-polycytidylic acid (poly I:C), cyclic polyphosphazene 75B (CPZ75B), avian beta-defensin 2 (ABD2), and combinations of these reagents given in ovo. Data derived from a series of animal experiments demonstrated that the in ovo administration of 10-50 µg CpG ODN/embryo (on embryonic day 18) is an effective formulation for control of yolk sac infection (YSI) due to avian pathogenic
Identifiants
pubmed: 35622731
pii: vetsci9050203
doi: 10.3390/vetsci9050203
pmc: PMC9142911
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Chicken Farmers of Saskatchewan (SCIDF)
ID : 421141
Organisme : Canadian Poultry Research Council (CPRC)/Agri-Agrifood Canada (AAFC)
ID : 421319
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