Antibody-mediated neutralization of SARS-CoV-2.
B cells
SARS-CoV-2
antibodies
immunization
neutralization
vaccination
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
14 06 2022
14 06 2022
Historique:
received:
28
03
2022
revised:
06
05
2022
accepted:
09
05
2022
pubmed:
28
5
2022
medline:
18
6
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.
Identifiants
pubmed: 35623355
pii: S1074-7613(22)00225-4
doi: 10.1016/j.immuni.2022.05.005
pmc: PMC9118976
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
925-944Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests H.G., K.V., T.W., C.K., and F.K. are listed as inventors on patent application(s) on virus neutralizing antibodies filed by the University of Cologne. C.O.B. declares no conflict of interest.
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