GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides.
Blood dosimetry
GATE
Geant4
Monte Carlo simulation
Radionuclide
Journal
Zeitschrift fur medizinische Physik
ISSN: 1876-4436
Titre abrégé: Z Med Phys
Pays: Germany
ID NLM: 100886455
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
19
11
2021
revised:
23
03
2022
accepted:
24
03
2022
pubmed:
28
5
2022
medline:
28
3
2023
entrez:
27
5
2022
Statut:
ppublish
Résumé
To establish a dose-response relationship between radiation-induced DNA damage and the corresponding absorbed doses in blood irradiated with radionuclides in solution under ex vivo conditions, the absorbed dose coefficient for 1 ml for 1 h internal ex vivo irradiation of peripheral blood (d The Monte Carlo simulation reproduces the irradiation geometry of a blood sample of 7 ml mixed with 1 ml of a water equivalent radioactive solution in an 8 ml vial. The simulation was performed for ten different radionuclides: The values of d This study provides a comprehensive set of absorbed dose coefficients for 1 ml for 1 h internal ex vivo irradiation of peripheral blood in a special vial geometry and radionuclides typically used in Nuclear Medicine. Furthermore, the method proposed by this work can be easily adapted to a variety of internal irradiation conditions and serve as a reference for future studies.
Identifiants
pubmed: 35623943
pii: S0939-3889(22)00038-1
doi: 10.1016/j.zemedi.2022.03.005
pmc: PMC10082371
pii:
doi:
Substances chimiques
Iodine-124
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-53Informations de copyright
Copyright © 2022. Published by Elsevier GmbH.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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