Single extracellular vesicle analysis for early cancer detection.
cancer
early detection
exosome
extracellular vesicle
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
04
03
2022
revised:
02
05
2022
accepted:
03
05
2022
pubmed:
28
5
2022
medline:
3
8
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are actively shed into the circulation from both cancer and host cells. EVs are emerging as one of the diagnostic frontrunners for early cancer detection, disease monitoring, and treatment evaluation. The advantages of EVs rely on the fact that vesicles are being shed by dividing tumor cells, with indications that human and viral oncogenes, cellular metabolic rate, and tumor characteristics such as pH and hypoxia contribute to the high shed rates in cancer. In this review, we provide an overview of EVs and the rationale for using them for early cancer detection. We examine emerging technologies for single EV analysis (sEVA) and why these technologies will be necessary for early cancer detection.
Identifiants
pubmed: 35624008
pii: S1471-4914(22)00111-3
doi: 10.1016/j.molmed.2022.05.003
pmc: PMC9339504
mid: NIHMS1817131
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
681-692Subventions
Organisme : NCI NIH HHS
ID : P01 CA069246
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA079443
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA237332
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA236561
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204019
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of interests R.W. is a consultant to ModeRNA, Tarveda Therapeutics, Lumicell, Seer, Earli, Aikili Biosystems, and Accure Health.
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