Diagnostic value of micrographia in Parkinson's disease: a study with [

Dopamine Plasma Membrane Transport Proteins / metabolism Essential Tremor Humans Iodine Radioisotopes Parkinson Disease / complications Tomography, Emission-Computed, Single-Photon / methods Tropanes
Dopamine transporter Essential tremor Micrographia Parkinson’s disease SPECT

Journal

Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341

Informations de publication

Date de publication:
07 2022
Historique:
received: 23 02 2022
accepted: 11 05 2022
pubmed: 28 5 2022
medline: 25 6 2022
entrez: 27 5 2022
Statut: ppublish

Résumé

Micrographia is a common symptom of Parkinson's disease (PD), and it may precede other motor symptoms. Despite the high prevalence of micrographia in PD, its neurobiological mechanisms are not known. Given that levodopa may alleviate consistent micrographia and that nondopaminergic essential tremor (ET) is not associated with micrographia, micrographia could possibly be used as an ancillary diagnostic method that reflects nigrostriatal dopamine function. We evaluated the usefulness of micrographia as a simple one-sentence writing test in differentiating PD from ET. A total of 146 PD patients, 42 ET patients and 38 healthy controls provided writing samples and were scanned with brain [

Identifiants

DOI: 10.1007/s00702-022-02517-1 PMID: 35624405 PMC: PMC9217822
pubmed: 35624405
doi: 10.1007/s00702-022-02517-1
pii: 10.1007/s00702-022-02517-1
pmc: PMC9217822
doi:

Substances chimiques

Dopamine Plasma Membrane Transport Proteins 0
Iodine Radioisotopes 0
Tropanes 0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane 155797-99-2
Iodine-123 8YWR746RPQ

Banques de données

ClinicalTrials.gov
['NCT02650843']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

895-904

Informations de copyright

© 2022. The Author(s).

Références

Adler CH, Beach TG, Hentz JG et al (2014) Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology 83(5):406–412. https://doi.org/10.1212/WNL.0000000000000641
doi: 10.1212/WNL.0000000000000641 pubmed: 24975862 pmcid: 4132570
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571. https://doi.org/10.1001/archpsyc.1961.01710120031004
doi: 10.1001/archpsyc.1961.01710120031004 pubmed: 13688369
Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G, Tremor Task Force of the International Parkinson and Movement Disorder Society (2018) Consensus Statement on the classification of tremors from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord 33(1):75–87. https://doi.org/10.1002/mds.27121
doi: 10.1002/mds.27121 pubmed: 29193359
Darcourt J, Booij J, Tatsch K et al (2010) EANM procedure guidelines for brain neurotransmission SPECT using (123)I-labelled dopamine transporter ligands, version 2. Eur J Nucl Med Mol Imaging 37(2):443–450. https://doi.org/10.1007/s00259-009-1267-x
doi: 10.1007/s00259-009-1267-x pubmed: 19838702
De la Froment M (1921) micrographie dans les etats parkinsoniens post- encephalitiques et des conditions qui sont susceptibles de la modifier. Rev Neurol 37:637–638
de la Fuente-Fernández R (2012) Role of DaTSCAN and clinical diagnosis in Parkinson disease. Neurology 78(10):696–701. https://doi.org/10.1212/WNL.0b013e318248e520
doi: 10.1212/WNL.0b013e318248e520 pubmed: 22323748
Diemling M (2012) Instructions on implementation of phantom based camera corrections for Enc-Dat BRASS. Hermes Med Solut. 14:2012
Fereshtehnejad SM, Yao C, Pelletier A, Montplaisir JY, Gagnon JF, Postuma RB (2019) Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study. Brain 142(7):2051–2067. https://doi.org/10.1093/brain/awz111
doi: 10.1093/brain/awz111 pubmed: 31111143
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198. https://doi.org/10.1016/0022-3956(75)90026-6
doi: 10.1016/0022-3956(75)90026-6 pubmed: 1202204
Goetz CG, Tilley BC, Shaftman SR et al (2008) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23(15):2129–2170. https://doi.org/10.1002/mds.22340
doi: 10.1002/mds.22340 pubmed: 19025984
Hajian-Tilaki K (2013) Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian J Intern Med 4(2):627–635
pubmed: 24009950 pmcid: 3755824
Inzelberg R, Plotnik M, Harpaz NK, Flash T (2016) Micrographia, much beyond the writer’s hand. Parkinsonism Relat Disord 26:1–9. https://doi.org/10.1016/j.parkreldis.2016.03.003
doi: 10.1016/j.parkreldis.2016.03.003 pubmed: 26997656
Joutsa J, Gardberg M, Röyttä M, Kaasinen V (2014) Diagnostic accuracy of parkinsonism syndromes by general neurologists. Parkinsonism Relat Disord 20(8):840–844. https://doi.org/10.1016/j.parkreldis.2014.04.019
doi: 10.1016/j.parkreldis.2014.04.019 pubmed: 24816002
Kaasinen V (2016) Ipsilateral deficits of dopaminergic neurotransmission in Parkinson’s disease. Ann Clin Transl Neurol 3(1):21–26. https://doi.org/10.1002/acn3.268
doi: 10.1002/acn3.268 pubmed: 26783547
Kaasinen V, Joutsa J, Noponen T, Johansson J, Seppänen M (2015) Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson’s disease. Neurobiol Aging 36(4):1757–1763. https://doi.org/10.1016/j.neurobiolaging.2015.01.016
doi: 10.1016/j.neurobiolaging.2015.01.016 pubmed: 25697414
Kim EJ, Lee BH, Park KC, Lee WY, Na DL (2005) Micrographia on free writing versus copying tasks in idiopathic Parkinson’s disease. Parkinsonism Relat Disord 11(1):57–63. https://doi.org/10.1016/j.parkreldis.2004.08.005
doi: 10.1016/j.parkreldis.2004.08.005 pubmed: 15619464
Koo TK, Li MY (2016) A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med 15(2):155–163. https://doi.org/10.1016/j.jcm.2016.02.012
doi: 10.1016/j.jcm.2016.02.012 pubmed: 27330520 pmcid: 4913118
Kulkarni O, Lafaver K, Tarsy D (2013) The, “floating door sign” in Parkinson’s disease. Parkinsonism Relat Disord 19(9):825–826. https://doi.org/10.1016/j.parkreldis.2013.04.013
doi: 10.1016/j.parkreldis.2013.04.013 pubmed: 23660546
Lange KW, Mecklinger L, Walitza S, Becker G, Gerlach M, Naumann M, Tucha O (2006a) Brain dopamine and kinematics of graphomotor functions. Hum Mov Sci 25(4–5):492–509. https://doi.org/10.1016/j.humov.2006.05.006
doi: 10.1016/j.humov.2006.05.006 pubmed: 16859791
Lange KW, Mecklinger L, Walitza S et al (2006b) Brain dopamine and kinematics of graphomotor functions. Hum Mov Sci 25(4–5):492–509. https://doi.org/10.1016/j.humov.2006.05.006
doi: 10.1016/j.humov.2006.05.006 pubmed: 16859791
Larner AJ (2011) A dictionary of neurological signs, 3rd edn. Springer, New York
doi: 10.1007/978-1-4419-7095-4
Letanneux A, Danna J, Velay JL, Viallet F, Pinto S (2014) From micrographia to Parkinson’s disease dysgraphia. Mov Disord 29(12):1467–1475. https://doi.org/10.1002/mds.25990
doi: 10.1002/mds.25990 pubmed: 25156696
Ling H, Massey LA, Lees AJ, Brown P, Day BL (2012) Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson’s disease. Brain 135(4):1141–1153. https://doi.org/10.1093/brain/aws038
doi: 10.1093/brain/aws038 pubmed: 22396397 pmcid: 3326257
Martinez-Hernandez HR, Louis ED (2014) Macrographia in essential tremor: a study of patients with and without rest tremor. Mov Disord 29(7):960–961. https://doi.org/10.1002/mds.25894
doi: 10.1002/mds.25894 pubmed: 24757126 pmcid: 4057948
McLennan JE, Nakano K, Tyler HR, Schwab RS (1972) Micrographia in Parkinson’s disease. J Neurol Sci 15(2):141–152. https://doi.org/10.1016/0022-510x(72)90002-0
doi: 10.1016/0022-510x(72)90002-0 pubmed: 5010101
Pick A (1903) Uber eine eigenthumliche schreibstorung, mikrographie, in folge cerebraler erkrankung. Prag. Med. Wochenscher 28:1–4
Pirker W (2003) Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? Mov Disord 18(7):S43-51. https://doi.org/10.1002/mds.10579
doi: 10.1002/mds.10579 pubmed: 14531046
Wilson SAK (1925) Some disorders of motility and of muscle tone, with special reference to the corpus striatum. The Lancet 206:268–276 (p 1-10; 53-62; 169-178)
doi: 10.1016/S0140-6736(01)17257-0
SPM12. Available at https://www.fil.ion.ucl.ac.uk/spm/software/spm12/ . Accessed 14 January 2022.
Tossici-Bolt L, Dickson JC, Sera T et al (2011) Calibration of gamma camera systems for a multicentre European
doi: 10.1007/s00259-011-1801-5 pubmed: 21468761
Varrone A, Dickson JC, Tossici-Bolt L et al (2013) European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging 40(2):213–227. https://doi.org/10.1007/s00259-012-2276-8
doi: 10.1007/s00259-012-2276-8 pubmed: 23160999
Wu T, Zhang J, Hallett M, Feng T, Hou Y, Chan P (2016) Neural correlates underlying micrographia in Parkinson’s disease. Brain 139(1):144–160. https://doi.org/10.1093/brain/awv319
doi: 10.1093/brain/awv319 pubmed: 26525918
Wagle Shukla A, Ounpraseuth S, Okun MS, Gray V, Schwankhaus J, Metzer WS (2012) Micrographia and related deficits in Parkinson’s disease: a cross-sectional study. BMJ Open. https://doi.org/10.1136/bmjopen-2011-000628
doi: 10.1136/bmjopen-2011-000628 pubmed: 22734114 pmcid: 3383984
WFU_PickAtlas. Available at  https://www.nitrc.org/projects/wfu_pickatlas/ . Accessed 14 January 2022.

Auteurs

Mikael Eklund (M)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland. mreekl@utu.fi.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland. mreekl@utu.fi.
Turku PET Centre, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland. mreekl@utu.fi.
ORCID: 0000-0002-1947-712X

Simo Nuuttila (S)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.

Juho Joutsa (J)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.
Turku PET Centre, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.
Turku Brain and Mind Center, University of Turku, FI-20014, Turku, Finland.

Elina Jaakkola (E)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.

Elina Mäkinen (E)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Department of Neurology, Helsinki University Hospital HUS, Helsinki, Finland.
Department of Clinical Neurosciences, University of Helsinki HUS, PO Box 800, FI-00029, Helsinki, Finland.

Emma A Honkanen (EA)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.
Turku PET Centre, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.

Kari Lindholm (K)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.

Tero Vahlberg (T)

Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.

Tommi Noponen (T)

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.
Department of Medical Physics, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.

Toni Ihalainen (T)

HUS Medical Imaging Center, Clinical Physiology and Nuclear Medicine, University of Helsinki and Helsinki University Hospital HUS, PO Box 800, FI-00029, Helsinki, Finland.

Kirsi Murtomäki (K)

Department of Neurology, Helsinki University Hospital HUS, Helsinki, Finland.
Department of Clinical Neurosciences, University of Helsinki HUS, PO Box 800, FI-00029, Helsinki, Finland.

Tanja Nojonen (T)

Department of Neurology, Helsinki University Hospital HUS, Helsinki, Finland.
Department of Clinical Neurosciences, University of Helsinki HUS, PO Box 800, FI-00029, Helsinki, Finland.

Reeta Levo (R)

Department of Neurology, Helsinki University Hospital HUS, Helsinki, Finland.
Department of Clinical Neurosciences, University of Helsinki HUS, PO Box 800, FI-00029, Helsinki, Finland.

Tuomas Mertsalmi (T)

Department of Neurology, Helsinki University Hospital HUS, Helsinki, Finland.
Department of Clinical Neurosciences, University of Helsinki HUS, PO Box 800, FI-00029, Helsinki, Finland.

Filip Scheperjans (F)

Department of Neurology, Helsinki University Hospital HUS, Helsinki, Finland.
Department of Clinical Neurosciences, University of Helsinki HUS, PO Box 800, FI-00029, Helsinki, Finland.

Valtteri Kaasinen (V)

Clinical Neurosciences, University of Turku, FI-20014, Turku, Finland.
Neurocenter, Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.
Turku Brain and Mind Center, University of Turku, FI-20014, Turku, Finland.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la dopamine › Diagnostic value of micrographia in...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Troubles de la motricité › Tremblement essentiel › Diagnostic value of micrographia in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diagnostic value of micrographia in...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes de l'iode › Diagnostic value of micrographia in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Diagnostic value of micrographia in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Diagnostic value of micrographia in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Tropanes › Diagnostic value of micrographia in...