Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system.
Central nervous system
Interleukin-6
Neuroinflammation
SBNO2
Strawberry notch homolog 2
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
27 May 2022
27 May 2022
Historique:
received:
02
12
2021
accepted:
15
05
2022
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
The cytokine interleukin-6 (IL-6) modulates a variety of inflammatory processes and, context depending, can mediate either pro- or anti-inflammatory effects. Excessive IL-6 signalling in the brain is associated with chronic inflammation resulting in neurodegeneration. Strawberry notch homolog 2 (Sbno2) is an IL-6-regulated gene whose function is largely unknown. Here we aimed to address this issue by investigating the impact of Sbno2 disruption in mice with IL-6-mediated neuroinflammation. Mice with germline disruption of Sbno2 (Sbno2 We found Sbno2 Based on these results, we propose a role for SBNO2 as a novel negative feedback regulator of IL-6 that restrains the excessive inflammatory actions of this cytokine in the brain.
Sections du résumé
BACKGROUND
BACKGROUND
The cytokine interleukin-6 (IL-6) modulates a variety of inflammatory processes and, context depending, can mediate either pro- or anti-inflammatory effects. Excessive IL-6 signalling in the brain is associated with chronic inflammation resulting in neurodegeneration. Strawberry notch homolog 2 (Sbno2) is an IL-6-regulated gene whose function is largely unknown. Here we aimed to address this issue by investigating the impact of Sbno2 disruption in mice with IL-6-mediated neuroinflammation.
METHODS
METHODS
Mice with germline disruption of Sbno2 (Sbno2
RESULTS
RESULTS
We found Sbno2
CONCLUSION
CONCLUSIONS
Based on these results, we propose a role for SBNO2 as a novel negative feedback regulator of IL-6 that restrains the excessive inflammatory actions of this cytokine in the brain.
Identifiants
pubmed: 35624480
doi: 10.1186/s12974-022-02475-1
pii: 10.1186/s12974-022-02475-1
pmc: PMC9145108
doi:
Substances chimiques
Cytokines
0
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126Subventions
Organisme : National Health and Medical Research Council
ID : APP1047265
Informations de copyright
© 2022. The Author(s).
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