Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study.
asthma
chronic diseases
fluorescent oxidation products
genome-wide association study
oxidative stress
smoking
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
20 Apr 2022
20 Apr 2022
Historique:
received:
17
02
2022
revised:
13
04
2022
accepted:
18
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Oxidative stress (OS) is the main pathophysiological mechanism involved in several chronic diseases, including asthma. Fluorescent oxidation products (FlOPs), a global biomarker of damage due to OS, is of growing interest in epidemiological studies. We conducted a genome-wide association study (GWAS) of the FlOPs level in 1216 adults from the case-control and family-based EGEA study (mean age 43 years old, 51% women, and 23% current smokers) to identify genetic variants associated with FlOPs. The GWAS was first conducted in the whole sample and then stratified according to smoking status, the main exogenous source of reactive oxygen species. Among the top genetic variants identified by the three GWAS, those located in
Identifiants
pubmed: 35624665
pii: antiox11050802
doi: 10.3390/antiox11050802
pmc: PMC9137810
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : French Agency for Food, Environmental and Occupational Health & Safety
ID : PNR-EST 2017
Organisme : National Hospital program of clinical research
ID : PHRC-National 2012, EvAdA
Organisme : National Research Agency - Health Environment, Health-Work Program
ID : ANR-CES-2009, BIO2NEA
Organisme : the Fonds AGIR pour les maladies chroniques
ID : No Number
Organisme : the Region Hauts de France
ID : No Number
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