Neuropsychiatric Disorders in Pediatric Long COVID-19: A Case Series.
COVID-19 haulers
SARS-CoV-2 infection
kynurenines
long COVID-19
movement disorders
neuroinflammation
neuropsychiatric disorders
pandemic stress
psychosis
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
19 Apr 2022
19 Apr 2022
Historique:
received:
07
03
2022
revised:
10
04
2022
accepted:
14
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Few data are available regarding the incidence and the evolution of neuropsychiatric manifestations in children with a history of COVID-19. We herein report five consequent cases of pediatric patients with psychiatric and neurological symptoms of long COVID-19. All patients, mainly males, reported asymptomatic-to-mild COVID-19 and underwent home self-isolation. Abnormal movements, anxiety, and emotional dysregulation were the most recurrent symptoms observed from a few weeks to months after the resolution of the acute infection. A later onset was observed in younger patients. Blood tests and brain imaging resulted in negative results in all subjects; pharmacological and cognitive behavioral therapy was set. A multifactorial etiology could be hypothesized in these cases, as a result of a complex interplay between systemic and brain inflammation and environmental stress in vulnerable individuals. Longer follow-up is required to observe the evolution of neuropsychiatric manifestation in the present cohort and other young patients with previous SARS-CoV-2 infection.
Identifiants
pubmed: 35624901
pii: brainsci12050514
doi: 10.3390/brainsci12050514
pmc: PMC9138973
pii:
doi:
Types de publication
Case Reports
Langues
eng
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