A High Methylation Level of a Novel -284 bp CpG Island in the
DNA methylation
RAMP1
epigenetics
migraine
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
21 Apr 2022
21 Apr 2022
Historique:
received:
18
03
2022
revised:
14
04
2022
accepted:
17
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Migraine is a complex neurovascular disorder affecting one billion people worldwide, mainly females. It is characterized by attacks of moderate to severe headache pain, with associated symptoms. Receptor activity modifying protein (RAMP1) is part of the Calcitonin Gene-Related Peptide (CGRP) receptor, a pharmacological target for migraine. Epigenetic processes, such as DNA methylation, play a role in clinical presentation of various diseases. DNA methylation occurs mostly in the gene promoter and can control gene expression. We investigated the methylation state of the
Identifiants
pubmed: 35624913
pii: brainsci12050526
doi: 10.3390/brainsci12050526
pmc: PMC9139045
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cooperation Programme Interreg V-A Spain-Portugal
ID : 0702_MIGRAINEE_2_E
Organisme : Fundação para a Ciência e Tecnologia
ID : PTDC/MEC-NEU/29486/2017
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