Lack of Ecto-5'-Nucleotidase Protects Sensitized Mice against Allergen Challenge.
B cells
CD23
CD73
airways
allergy
ecto-5′-nucleotidase
hyperresponsiveness
mast cells
sensitization
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
13 05 2022
13 05 2022
Historique:
received:
31
03
2022
revised:
03
05
2022
accepted:
11
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Ecto-5'-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required for the assessment of a controlled allergic sensitization, in mice. Here, we evaluated the response to aerosolized allergen of female-sensitized mice lacking CD73 in comparison with their wild type counterpart. Results obtained show, in mice lacking CD73, the absence of airway hyperreactivity in response to an allergen challenge, paralleled by reduced airway CD23
Identifiants
pubmed: 35625624
pii: biom12050697
doi: 10.3390/biom12050697
pmc: PMC9139122
pii:
doi:
Substances chimiques
Allergens
0
5'-Nucleotidase
EC 3.1.3.5
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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