Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators.
adipose tissue
arachidonic acid
body mass index
breast cancer
fatty acids
long-chain polyunsaturated fatty acid n-6
obesity
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
26 Apr 2022
26 Apr 2022
Historique:
received:
21
03
2022
revised:
14
04
2022
accepted:
18
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
While obesity is linked to cancer risk, no studies have explored the consequences of body mass index (BMI) on fatty acid profiles in breast adipose tissue and on breast tumor aggressiveness indicators. Because of this, 261 breast adipose tissue samples of women with invasive breast carcinoma were analyzed. Fatty acid profile was established by gas chromatography. For normal-weight women, major changes in fatty acid profile occurs after menopause, with the enrichment of long-chain polyunsaturated fatty acids (LC-PUFAs) of both n-6 and n-3 series enrichment, but a stable LC-PUFAs n-6/n-3 ratio across age. BMI impact was analyzed by age subgroups to overcome the age effect. BMI increase is associated with LC-PUFAs n-6 accumulation, including arachidonic acid. Positive correlations between BMI and several LC-PUFAs n-6 were observed, as well as a strong imbalance in the LC-PUFAs n-6/n-3 ratio. Regarding cancer, axillary lymph nodes (
Identifiants
pubmed: 35625732
pii: biomedicines10050995
doi: 10.3390/biomedicines10050995
pmc: PMC9138452
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Inserm
ID : No Number
Organisme : Université de Tours
ID : No Number
Organisme : Cancéropôle Grand Ouest
ID : No Number
Organisme : Région Centre-Val de Loire
ID : No Number
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