Combination of Glycinamide and Ascorbic Acid Synergistically Promotes Collagen Production and Wound Healing in Human Dermal Fibroblasts.
ascorbic acid
collagen production
dermal fibroblasts
glycinamide
glycine
wound healing
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
29 Apr 2022
29 Apr 2022
Historique:
received:
23
02
2022
revised:
18
04
2022
accepted:
27
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
The purpose of this study is to present a novel strategy to enhance collagen production in cells. To identify amino acid analogs with excellent collagen production-enhancing effects, human dermal fibroblasts (HDFs) were treated with 20 kinds of amidated amino acids and 20 kinds of free amino acids, individually at 1 mM. The results showed that glycinamide enhanced collagen production (secreted collagen level) most effectively. Glycine also enhanced collagen production to a lesser degree. However, other glycine derivatives, such as N-acetyl glycine, N-acetyl glycinamide, glycine methyl ester, glycine ethyl ester, and glycyl glycine, did not show such effects. Glycinamide increased type I and III collagen protein levels without affecting
Identifiants
pubmed: 35625765
pii: biomedicines10051029
doi: 10.3390/biomedicines10051029
pmc: PMC9138459
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Korea Health Industry Development Institute
ID : HP20C0004
Pays : Republic of Korea
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