Thirty-Five-Year History of Desialylated Lipoproteins Discovered by Vladimir Tertov.

atherogenicity atherosclerosis desialylation low-density lipoproteins (LDL) sialidase trans-sialidase

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
19 May 2022
Historique:
received: 27 04 2022
revised: 17 05 2022
accepted: 17 05 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 29 5 2022
Statut: epublish

Résumé

Atherosclerosis is one of the leading causes of death in developed and developing countries. The atherogenicity phenomenon cannot be separated from the role of modified low-density lipoproteins (LDL) in atherosclerosis development. Among the multiple modifications of LDL, desialylation deserves to be discussed separately, since its atherogenic effects and contribution to atherogenicity are often underestimated or, simply, forgotten. Vladimir Tertov is linked to the origin of the research related to desialylated lipoproteins, including the association of modified LDL with atherogenicity, autoimmune nature of atherosclerosis, and discovery of sialidase activity in blood plasma. The review will briefly discuss all the above-mentioned information, with a description of the current situation in the research.

Identifiants

pubmed: 35625910
pii: biomedicines10051174
doi: 10.3390/biomedicines10051174
pmc: PMC9138341
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Russian Science Foundation
ID : 20-15-00264

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Auteurs

Victor Glanz (V)

Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.

Evgeny E Bezsonov (EE)

Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Department of Biology and General Genetics, I. M. Sechenov First Moscow State Medical University (Sechenov University), 105043 Moscow, Russia.

Vladislav Soldatov (V)

Pharmacology and Clinical Pharmacology Department, Belgorod State National Research University, 308015 Belgorod, Russia.

Alexander N Orekhov (AN)

Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.

Classifications MeSH