OncoPan
HER2 amplification
HR genes mutations
OncoPan® NGS analysis
pancreatic adenocarcinoma
risk assessment
target therapy
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
23 May 2022
23 May 2022
Historique:
received:
27
04
2022
revised:
17
05
2022
accepted:
17
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Pancreatic cancer has a high morbidity and mortality with the majority being PC ductal adenocarcinomas (PDAC). Whole genome sequencing provides a wide description of genomic events involved in pancreatic carcinogenesis and identifies putative biomarkers for new therapeutic approaches. However, currently, there are no approved treatments targeting driver mutations in PDAC that could produce clinical benefit for PDAC patients. A proportion of 5-10% of PDAC have a hereditary origin involving germline variants of homologous recombination genes, such as Mismatch Repair (MMR),
Identifiants
pubmed: 35625944
pii: biomedicines10051208
doi: 10.3390/biomedicines10051208
pmc: PMC9138989
pii:
doi:
Types de publication
Journal Article
Langues
eng
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