Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review.
desmoplastic reaction
gemcitabine
hydroxyurea
pancreatic ductal adenocarcinoma
proteasome inhibitors
resistance to treatment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 May 2022
18 May 2022
Historique:
received:
29
03
2022
revised:
11
05
2022
accepted:
13
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a poor prognosis and inadequate response to treatment. Many factors contribute to this therapeutic failure: lack of symptoms until the tumor reaches an advanced stage, leading to late diagnosis; early lymphatic and hematic spread; advanced age of patients; important development of a pro-tumoral and hyperfibrotic stroma; high genetic and metabolic heterogeneity; poor vascular supply; a highly acidic matrix; extreme hypoxia; and early development of resistance to the available therapeutic options. In most cases, the disease is silent for a long time, andwhen it does become symptomatic, it is too late for ablative surgery; this is one of the major reasons explaining the short survival associated with the disease. Even when surgery is possible, relapsesare frequent, andthe causes of this devastating picture are the low efficacy ofand early resistance to all known chemotherapeutic treatments. Thus, it is imperative to analyze the roots of this resistance in order to improve the benefits of therapy. PDAC chemoresistance is the final product of different, but to some extent, interconnected factors. Surgery, being the most adequate treatment for pancreatic cancer and the only one that in a few selected cases can achieve longer survival, is only possible in less than 20% of patients. Thus, the treatment burden relies on chemotherapy in mostcases. While the FOLFIRINOX scheme has a slightly longer overall survival, it also produces many more adverse eventsso that gemcitabine is still considered the first choice for treatment, especially in combination with other compounds/agents. This review discusses the multiple causes of gemcitabine resistance in PDAC.
Identifiants
pubmed: 35626089
pii: cancers14102486
doi: 10.3390/cancers14102486
pmc: PMC9139729
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : the European Marie Skłodowska-Curie Innovative Training Network (ITN) pH and Ion Transport in Pancreatic Cancer-pHioniC
ID : 813834; H2020-MSCA-ITN-2018
Références
Molecules. 2013 Jun 04;18(6):6584-96
pubmed: 23736792
Cancers (Basel). 2019 Mar 07;11(3):
pubmed: 30866547
Biomed Res Int. 2018 Mar 6;2018:3195025
pubmed: 29693005
Pancreas. 2010 Nov;39(8):1284-92
pubmed: 20944490
Mol Cancer Ther. 2008 Aug;7(8):2415-25
pubmed: 18723487
Cancer. 2002 Aug 15;95(4 Suppl):928-32
pubmed: 12209673
Br J Cancer. 2007 Aug 20;97(4):523-30
pubmed: 17622249
J Adv Res. 2019 Apr 24;20:9-21
pubmed: 31193017
Cancer Med. 2021 Oct;10(20):7233-7241
pubmed: 34559451
Drug Metab Dispos. 2020 Mar;48(3):153-158
pubmed: 31871136
FASEB J. 1992 Apr;6(7):2397-404
pubmed: 1563592
Gut. 2019 Nov;68(11):1994-2006
pubmed: 30826748
Dig Dis Sci. 2009 Jan;54(1):89-96
pubmed: 18594980
Biomed Pharmacother. 2019 Jan;109:1008-1015
pubmed: 30551350
Pancreas. 1994 Mar;9(2):193-202
pubmed: 8190721
Transl Res. 2019 May;207:56-69
pubmed: 30653942
Eur J Cell Biol. 1992 Jun;58(1):28-34
pubmed: 1644063
Clin Cancer Res. 2021 Nov 15;27(22):6222-6234
pubmed: 34475103
Nature. 2019 Oct;574(7777):264-267
pubmed: 31578522
Cancer Chemother Pharmacol. 2002 Nov;50(5):353-9
pubmed: 12439592
Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):370-383
pubmed: 30373903
Cancer Lett. 2013 Nov 28;341(1):41-5
pubmed: 23973264
JAMA. 2013 Oct 9;310(14):1473-81
pubmed: 24104372
Int J Oncol. 1994 Sep;5(3):485-8
pubmed: 21559602
Cancer Cell. 2011 Apr 12;19(4):441-55
pubmed: 21481787
Oncotarget. 2016 Mar 29;7(13):16396-408
pubmed: 26918939
Cancer Lett. 2017 Jul 1;397:43-51
pubmed: 28336327
J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:15-8
pubmed: 22320910
Theranostics. 2020 Mar 4;10(9):3967-3979
pubmed: 32226532
Adv Exp Med Biol. 2014;816:129-51
pubmed: 24818722
Cancer Detect Prev. 2006;30(3):284-91
pubmed: 16844323
Oncogene. 2014 Jun 5;33(23):2956-67
pubmed: 23851493
Drug Resist Updat. 2002 Dec;5(6):234-48
pubmed: 12531180
J Pathol. 2018 Dec;246(4):395-404
pubmed: 30105857
World J Gastroenterol. 2013 Feb 28;19(8):1173-81
pubmed: 23482354
Cell. 2008 May 16;133(4):704-15
pubmed: 18485877
Int J Cancer. 2012 May 15;130(10):2337-48
pubmed: 21780106
Clin Cancer Res. 2006 Apr 15;12(8):2492-7
pubmed: 16638857
Cell Death Dis. 2017 Dec 12;8(12):3204
pubmed: 29233971
J Hematol Oncol. 2012 Oct 26;5:68
pubmed: 23102107
Mol Cancer. 2020 Sep 2;19(1):135
pubmed: 32878635
Cancer. 2018 Apr 1;124(7):1374-1382
pubmed: 29338080
Int J Oncol. 2018 Jul;53(1):215-224
pubmed: 29693166
Biol Pharm Bull. 2002 Dec;25(12):1555-61
pubmed: 12499639
Gastroenterology. 2013 Nov;145(5):1121-32
pubmed: 23891972
Cancer Genet Cytogenet. 2005 Apr 15;158(2):119-25
pubmed: 15796958
Cell Death Dis. 2021 Mar 29;12(4):334
pubmed: 33782384
Front Immunol. 2015 May 26;6:235
pubmed: 26074915
Am J Pathol. 2013 Mar;182(3):965-74
pubmed: 23438477
Cancer Lett. 2017 Mar 1;388:107-117
pubmed: 27940128
Cell Death Dis. 2016 Jul 14;7:e2295
pubmed: 27415425
Oncogene. 2017 Mar 30;36(13):1770-1778
pubmed: 27669441
Cancer Lett. 2018 May 1;421:127-134
pubmed: 29432846
Oncotarget. 2017 Jun 28;8(38):63461-63483
pubmed: 28969005
Cell Death Dis. 2013 May 09;4:e627
pubmed: 23661005
J Immunol. 2014 Aug 1;193(3):1006-11
pubmed: 25049431
Am J Pathol. 2011 Mar;178(3):956-63
pubmed: 21356346
Curr Pharm Des. 2012;18(17):2472-81
pubmed: 22372499
Carcinogenesis. 2020 Sep 24;41(9):1173-1183
pubmed: 32710608
Cancer Res. 1998 Oct 1;58(19):4349-57
pubmed: 9766663
Pancreas. 2009 Oct;38(7):e190-9
pubmed: 19730150
Oncogene. 2017 Jun 1;36(22):3094-3103
pubmed: 27941872
World J Oncol. 2019 Feb;10(1):10-27
pubmed: 30834048
Int J Mol Sci. 2019 Sep 04;20(18):
pubmed: 31487880
EBioMedicine. 2020 Mar;53:102662
pubmed: 32139180
World J Gastroenterol. 2018 Aug 7;24(29):3222-3238
pubmed: 30090003
Oncogenesis. 2016 Jan 18;5:e185
pubmed: 26779808
Proteomics. 2013 May;13(10-11):1672-86
pubmed: 23585443
Neoplasia. 2016 Dec;18(12):732-741
pubmed: 27886639
PLoS One. 2014 May 01;9(5):e95486
pubmed: 24788257
Front Oncol. 2021 Oct 06;11:751311
pubmed: 34692532
Cancer Lett. 2013 Sep 10;338(1):94-100
pubmed: 22445908
Drug Resist Updat. 1998;1(5):310-24
pubmed: 17092812
Cancer Res. 2007 Mar 1;67(5):2187-96
pubmed: 17332349
Target Oncol. 2017 Jun;12(3):309-321
pubmed: 28353074
Mol Carcinog. 2012 Jan;51(1):64-74
pubmed: 22162232
Eur J Pharmacol. 2014 Oct 15;741:8-16
pubmed: 25084222
Cancer Lett. 2020 Aug 1;484:9-15
pubmed: 32380129
Mol Cancer Ther. 2019 Oct;18(10):1744-1754
pubmed: 31308076
Am J Respir Cell Mol Biol. 2017 Jul;57(1):77-90
pubmed: 28257580
Gut. 2017 Dec;66(12):2170-2178
pubmed: 28993418
Oncotarget. 2016 Sep 6;7(36):58649-58658
pubmed: 27462915
Cell Oncol (Dordr). 2020 Feb;43(1):123-136
pubmed: 31713003
Pflugers Arch. 2004 Feb;447(5):735-43
pubmed: 12838422
Oncol Res. 2016;24(2):129-35
pubmed: 27296953
Oncotarget. 2015 Jun 20;6(17):15524-39
pubmed: 25906749
J Gastrointest Surg. 2006 Nov;10(9):1254-62; discussion 1263
pubmed: 17114012
Int J Mol Sci. 2012 Dec 21;14(1):226-43
pubmed: 23344030
Oncogene. 2013 Aug 15;32(33):3867-76
pubmed: 22945649
Sci Rep. 2020 Jul 22;10(1):12192
pubmed: 32699225
JCI Insight. 2020 Jun 18;5(12):
pubmed: 32427590
Cancer. 2013 Jan 1;119(1):173-81
pubmed: 22736490
PLoS One. 2011;6(11):e27725
pubmed: 22140463
Mol Cancer Ther. 2013 Jun;12(6):992-1001
pubmed: 23729403
Int J Oncol. 2001 Apr;18(4):767-73
pubmed: 11251172
Sci Rep. 2020 Dec 3;10(1):21194
pubmed: 33273652
J Gastrointest Surg. 2015 Oct;19(10):1813-21
pubmed: 26286368
Front Physiol. 2012 Jul 13;3:270
pubmed: 22969725
Anticancer Res. 2018 Nov;38(11):6271-6279
pubmed: 30396947
Biomedicines. 2021 May 23;9(6):
pubmed: 34071109
Cancer J. 2012 Nov-Dec;18(6):502-10
pubmed: 23187836
Cell. 2011 Jul 8;146(1):148-63
pubmed: 21729786
Cancers (Basel). 2019 Apr 26;11(5):
pubmed: 31035512
Cancer Manag Res. 2020 Jul 09;12:5597-5605
pubmed: 32753972
Pancreas. 2012 Jan;41(1):107-13
pubmed: 21926937
J Cell Biol. 2017 Nov 6;216(11):3799-3816
pubmed: 29021221
Cancer Manag Res. 2020 Jan 31;12:743-758
pubmed: 32099470
Biology (Basel). 2019 Dec 28;9(1):
pubmed: 31905604
Biochemistry. 2003 Oct 28;42(42):12163-73
pubmed: 14567677
Cancer Sci. 2018 Apr;109(4):1135-1146
pubmed: 29444383
Science. 2009 Jun 12;324(5933):1457-61
pubmed: 19460966
Cancer Res. 2000 Nov 1;60(21):6075-9
pubmed: 11085530
Clin Cancer Res. 2016 Jan 15;22(2):395-404
pubmed: 26369630
Cancer Res. 2005 Oct 15;65(20):9510-6
pubmed: 16230416
Drug Res (Stuttg). 2016 Nov;66(11):571-579
pubmed: 27701712
Cell Oncol (Dordr). 2018 Jun;41(3):223-252
pubmed: 29667069
Am J Respir Cell Mol Biol. 2016 Jan;54(1):51-9
pubmed: 26072676
Clin Cancer Res. 2008 Apr 15;14(8):2476-83
pubmed: 18413840
Oncotarget. 2016 Jun 28;7(26):39363-39375
pubmed: 27276704
Gastroenterology. 2020 Nov;159(5):1657-1659
pubmed: 32918911
Theranostics. 2022 Jan 1;12(3):999-1011
pubmed: 35154471
Oncogenesis. 2013 Jun 17;2:e51
pubmed: 23774063
Surgery. 2002 Feb;131(2):129-34
pubmed: 11854689
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3133-6
pubmed: 9873690
Cancer Res. 2008 Feb 1;68(3):918-26
pubmed: 18245495
Ann Surg Oncol. 2015 Dec;22(13):4402-10
pubmed: 25905586
Int J Oncol. 2012 Dec;41(6):2093-102
pubmed: 23026911
J Surg Res. 2001 Sep;100(1):11-7
pubmed: 11516199
Gut. 2006 Jan;55(1):79-89
pubmed: 16043492
PLoS One. 2015 Dec 07;10(12):e0141392
pubmed: 26641266
Mol Cancer. 2003 Jan 06;2:4
pubmed: 12556242
Pancreas. 2017 Feb;46(2):190-197
pubmed: 27846148
Carcinogenesis. 2012 Oct;33(10):1953-64
pubmed: 22791819
Int J Oncol. 2016 Jul;49(1):99-110
pubmed: 27177126
Cancers (Basel). 2019 May 08;11(5):
pubmed: 31072019
Clin Exp Metastasis. 2009;26(7):611-23
pubmed: 19421880
Future Oncol. 2009 Apr;5(3):305-8
pubmed: 19374537
Oncol Lett. 2018 Aug;16(2):1892-1898
pubmed: 30008881
Gastroenterology. 2012 Sep;143(3):664-674.e6
pubmed: 22705007
Cancer Lett. 2015 Mar 1;358(1):59-66
pubmed: 25527450
Curr Pharm Des. 2021;27(2):197-205
pubmed: 33290196
Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188676
pubmed: 35016922
Oncoscience. 2015 Mar 28;2(3):247-51
pubmed: 25897428
Pancreatology. 2010;10(6):673-81
pubmed: 21242706
PLoS One. 2016 Feb 09;11(2):e0148807
pubmed: 26859746
J Am Chem Soc. 2020 Mar 11;142(10):4944-4954
pubmed: 32069041
Adv Biol Regul. 2015 Sep;59:19-35
pubmed: 26166735
Am J Pathol. 2000 Jun;156(6):2123-33
pubmed: 10854233
Cancer Cell. 2019 Dec 9;36(6):577-579
pubmed: 31951558
Vaccines (Basel). 2016 Jul 26;4(3):
pubmed: 27472370
J Pharm Pharm Sci. 2017;20(0):295-304
pubmed: 28885916
J Oral Microbiol. 2021 Feb 14;13(1):1887680
pubmed: 33628398
PLoS One. 2013 Jul 23;8(7):e67538
pubmed: 23935836
Small GTPases. 2017 Jan 2;8(1):38-42
pubmed: 27215184
Br J Cancer. 2007 Feb 12;96(3):457-63
pubmed: 17224927
Br J Cancer. 2014 Jan 21;110(2):409-20
pubmed: 24201748
Cells. 2021 Aug 09;10(8):
pubmed: 34440799
Medicines (Basel). 2015 Dec;2(4):310-327
pubmed: 27088079
Ann Surg Oncol. 2012 May;19(5):1644-62
pubmed: 22012027
Mol Cancer Res. 2009 May;7(5):624-33
pubmed: 19435817
Biochem Biophys Res Commun. 2019 Mar 19;510(4):508-514
pubmed: 30737032
Clin Cancer Res. 2011 Mar 1;17(5):959-64
pubmed: 21224375
JAMA Netw Open. 2021 Apr 1;4(4):e214708
pubmed: 33825840
Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7
pubmed: 21684285
Biochim Biophys Acta. 2012 Jan;1819(1):28-37
pubmed: 21978825
Curr Pharm Des. 2013;19(5):940-50
pubmed: 22973962
Oncotarget. 2017 May 11;8(42):71642-71656
pubmed: 29069735
Lancet Respir Med. 2020 Jan;8(1):25-33
pubmed: 31575509
Pancreas. 2004 Nov;29(4):254-63
pubmed: 15502640
Am J Clin Pathol. 2002 May;117(5):791-6
pubmed: 12090430
Clin Cancer Res. 2008 Mar 1;14(5):1284-5
pubmed: 18316544
Nat Commun. 2020 Sep 24;11(1):4841
pubmed: 32973176
Cancer Cell. 2012 Mar 20;21(3):327-9
pubmed: 22439929
Anticancer Drugs. 2009 Feb;20(2):131-40
pubmed: 19209030
Cancers (Basel). 2021 Jan 17;13(2):
pubmed: 33477340
Cell Signal. 2004 Aug;16(8):873-80
pubmed: 15157666
Biochem Soc Trans. 2018 Dec 17;46(6):1449-1462
pubmed: 30467123
Front Pharmacol. 2018 Jun 06;9:606
pubmed: 29928232
Cancer Res. 2001 Jan 15;61(2):550-5
pubmed: 11212248
Carcinogenesis. 2013 Dec;34(12):2870-9
pubmed: 23803693
Cancer Cell Int. 2020 Jun 16;20:249
pubmed: 32550827
Oncotarget. 2015 Nov 10;6(35):37151-68
pubmed: 26452221
Cancer Cell Int. 2013 Dec 05;13(1):119
pubmed: 24305593
Oncogenesis. 2017 Jul 3;6(7):e352
pubmed: 28671675
Biochem Pharmacol. 2009 Jun 1;77(11):1674-83
pubmed: 19428321
J Cell Mol Med. 2013 Jan;17(1):30-54
pubmed: 23301832
JAMA. 1995 May 24-31;273(20):1605-9
pubmed: 7745774
Cancer Cell. 2015 Apr 13;27(4):462-72
pubmed: 25858805
J Clin Oncol. 2007 May 20;25(15):1960-6
pubmed: 17452677
Oncol Lett. 2012 Jun;3(6):1186-1190
pubmed: 22783415
Oncotarget. 2015 Apr 10;6(10):8313-22
pubmed: 25829252
Int J Mol Sci. 2013 Sep 27;14(10):19605-17
pubmed: 24084714
J Exp Clin Cancer Res. 2009 Jun 06;28:76
pubmed: 19500405
Cancer Cell. 2004 Feb;5(2):163-75
pubmed: 14998492
Gastroenterology. 2010 Aug;139(2):586-97, 597.e1-6
pubmed: 20452353
Skelet Muscle. 2021 Jul 6;11(1):17
pubmed: 34229732
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Jpn J Clin Oncol. 2019 Feb 1;49(2):190-194
pubmed: 30608598
Biochem Biophys Res Commun. 2011 Mar 25;406(4):552-7
pubmed: 21352803
Cancer Lett. 2022 Jul 10;538:215693
pubmed: 35472437
J Cell Mol Med. 2008 Dec;12(6A):2334-49
pubmed: 18266952
Am J Pathol. 2010 Nov;177(5):2585-96
pubmed: 20934972
Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L597-606
pubmed: 16257998
Semin Immunol. 2020 Feb;47:101389
pubmed: 31926647
Cancer Discov. 2021 Mar;11(3):660-677
pubmed: 34009137
Sci Rep. 2018 Feb 26;8(1):3593
pubmed: 29483523
Biochim Biophys Acta. 2013 Aug;1833(8):1947-59
pubmed: 23541910
World J Gastroenterol. 2014 Jul 14;20(26):8482-90
pubmed: 25024604
Semin Thromb Hemost. 2010 Nov;36(8):888-906
pubmed: 21049390
Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):469-481
pubmed: 34089011
PLoS One. 2011;6(6):e20636
pubmed: 21695188
Ann Surg Oncol. 2012 Jul;19 Suppl 3:S558-64
pubmed: 21913012
Neoplasia. 2007 Mar;9(3):222-35
pubmed: 17401462
Oncol Res Treat. 2018;41(10):603-610
pubmed: 30269131
JAMA. 2009 Oct 28;302(16):1790-5
pubmed: 19861671
Methods Mol Biol. 2018;1692:31-42
pubmed: 28986884
Life Sci. 2019 Jul 1;228:242-250
pubmed: 31075235
Int J Oncol. 2012 Mar;40(3):639-44
pubmed: 22200790
Mol Cancer Ther. 2014 Oct;13(10):2412-21
pubmed: 25053826
Gastroenterology. 2014 Nov;147(5):1119-33.e4
pubmed: 25127677
J Natl Cancer Inst. 2014 Jan;106(1):djt347
pubmed: 24301456
Best Pract Res Clin Gastroenterol. 2008;22(1):65-73
pubmed: 18206813
Anticancer Res. 2018 Oct;38(10):5799-5804
pubmed: 30275202
J Surg Res. 2008 Mar;145(1):111-23
pubmed: 17714734
World J Gastrointest Oncol. 2017 Jan 15;9(1):37-41
pubmed: 28144398
World J Gastroenterol. 2021 Oct 28;27(40):6844-6860
pubmed: 34790010
Braz J Med Biol Res. 2016 Jul 25;49(8):
pubmed: 27464025
Cancer Metastasis Rev. 2013 Dec;32(3-4):623-42
pubmed: 23709120
Cell Mol Life Sci. 2015 Feb;72(4):659-71
pubmed: 25336151
Dig Dis Sci. 2010 Apr;55(4):1167-76
pubmed: 19399612
Neoplasia. 2018 Aug;20(8):813-825
pubmed: 30015157
Nature. 2016 Mar 3;531(7592):47-52
pubmed: 26909576
Br J Cancer. 2007 Feb 12;96(3):507-9
pubmed: 17224924
Hepatogastroenterology. 2001 Sep-Oct;48(41):1321-7
pubmed: 11677955
Biochem Biophys Res Commun. 2015 Feb 27;458(1):14-20
pubmed: 25603055
Transl Oncol. 2020 Mar;13(3):100743
pubmed: 32145636
Cancer Lett. 2017 Jan 28;385:225-233
pubmed: 27773749
Dig Dis Sci. 2015 Apr;60(4):1067-80
pubmed: 25344906
J Biol Chem. 2001 Jan 26;276(4):2914-27
pubmed: 11032837
J Hematol Oncol. 2018 May 10;11(1):64
pubmed: 29747682
Pharmacogenet Genomics. 2014 Nov;24(11):564-74
pubmed: 25162786
Ann Surg Oncol. 2014 Jul;21(7):2453-62
pubmed: 24609291
Cancer Res. 2008 Oct 1;68(19):7811-8
pubmed: 18829536
Dev Cell. 2003 Aug;5(2):337-50
pubmed: 12919683
Clin Cancer Res. 2013 Dec 15;19(24):6703-15
pubmed: 24132924
Cancers (Basel). 2017 Nov 16;9(11):
pubmed: 29144412
Oncology. 2009;77(3-4):217-23
pubmed: 19729980
Br J Cancer. 2017 Feb 28;116(5):609-619
pubmed: 28152544
Neoplasia. 2016 Nov;18(11):689-698
pubmed: 27792935
Int J Biol Sci. 2016 Jan 28;12(3):338-46
pubmed: 26929740
Autophagy. 2021 Jun;17(6):1349-1366
pubmed: 32397857
World J Gastroenterol. 2014 Aug 28;20(32):11160-81
pubmed: 25170202
Br J Cancer. 2014 Aug 26;111(5):817-22
pubmed: 24755884
Oncol Rep. 2016 Jul;36(1):49-56
pubmed: 27220401
Connect Tissue Res. 2008;49(3):203-6
pubmed: 18661343
Nat Rev Dis Primers. 2016 Apr 21;2:16022
pubmed: 27158978
Oncotarget. 2014 Oct 30;5(20):9530-1
pubmed: 25393980
J Clin Invest. 2012 Feb;122(2):639-53
pubmed: 22232209
J Oncol. 2019 Aug 7;2019:3516973
pubmed: 31485223
Oncogene. 2020 May;39(21):4271-4285
pubmed: 32291413
Anticancer Res. 2016 Dec;36(12):6311-6318
pubmed: 27919951
Cell. 2012 Jan 20;148(1-2):21-3
pubmed: 22265397
ISRN Oncol. 2011;2011:936893
pubmed: 22091436
Oncogene. 2013 Mar 28;32(13):1714-23
pubmed: 22580602
Cancer Discov. 2012 Mar;2(3):260-269
pubmed: 22585996
Am J Surg. 2003 Sep;186(3):279-86
pubmed: 12946833
Eur J Pharmacol. 2018 Jan 5;818:593-603
pubmed: 29162433
Clin Cancer Res. 2012 Apr 1;18(7):2048-55
pubmed: 22338014
Oncotarget. 2015 Apr 30;6(12):9999-10015
pubmed: 25846752
Carcinogenesis. 2015 Jul;36(7):730-8
pubmed: 25939753
Br J Cancer. 2016 Sep 27;115(7):761-9
pubmed: 27537386
Mol Cancer Ther. 2016 Nov;15(11):2609-2619
pubmed: 27535971
Int J Cancer. 2009 Nov 15;125(10):2323-31
pubmed: 19598259
J Surg Res. 2003 Jul;113(1):88-95
pubmed: 12943815
Cancer Res. 2019 Nov 15;79(22):5723-5733
pubmed: 31484670
Cancer Res. 2006 Dec 15;66(24):11613-22
pubmed: 17178855
Cancers (Basel). 2015 Jul 31;7(3):1447-71
pubmed: 26264026
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):246-51
pubmed: 20018721
J Cell Mol Med. 2020 Mar;24(5):2917-2930
pubmed: 31989778
J Exp Clin Cancer Res. 2019 Mar 19;38(1):132
pubmed: 30890157
Nat Rev Gastroenterol Hepatol. 2011 Jan;8(1):27-33
pubmed: 21102532
Cancers (Basel). 2021 Jan 16;13(2):
pubmed: 33467038
Autophagy. 2011 Aug;7(8):912-3
pubmed: 21494085
Biol Pharm Bull. 2010;33(8):1261-7
pubmed: 20686216
Oncogene. 2018 Nov;37(44):5843-5857
pubmed: 29980787
Gastroenterology. 1998 Aug;115(2):421-32
pubmed: 9679048
Oncotarget. 2015 Feb 20;6(5):3085-97
pubmed: 25609203
Cancer Res. 2009 Mar 15;69(6):2400-7
pubmed: 19276344
Indian J Cancer. 2011 Jul-Sep;48(3):351-60
pubmed: 21921337
Acta Oncol. 2016;55(3):265-77
pubmed: 26213211
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
Biomed Pharmacother. 2021 Oct;142:112024
pubmed: 34399200
Am J Respir Crit Care Med. 2006 Dec 15;174(12):1352-60
pubmed: 17023731
Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81
pubmed: 22818416
Cancer J. 2014 Jan-Feb;20(1):80-4
pubmed: 24445769
Cancers (Basel). 2014 Oct 21;6(4):2137-54
pubmed: 25337831
Mol Cancer Ther. 2007 Mar;6(3):856-65
pubmed: 17363480
Cancer Res. 2002 May 15;62(10):2890-6
pubmed: 12019169
Cancer Res. 2009 Aug 15;69(16):6704-12
pubmed: 19654291
Gut. 2021 Mar;70(3):606-617
pubmed: 32855305
J Clin Pharm Ther. 2016 Dec;41(6):718-721
pubmed: 27670839
Chemistry. 2007;13(30):8507-15
pubmed: 17636467
Cancer. 2020 Sep 15;126(18):4087-4088
pubmed: 32459369
Cell Oncol (Dordr). 2017 Apr;40(2):167-180
pubmed: 28160167
Nat Cell Biol. 2017 May;19(5):518-529
pubmed: 28414315
Clin Cancer Res. 2017 Apr 1;23(7):1670-1678
pubmed: 28373365
Br J Cancer. 2010 Jun 29;103(1):52-60
pubmed: 20531411
Onco Targets Ther. 2018 Sep 12;11:5753-5762
pubmed: 30254468
Clin Cancer Res. 2020 Jul 1;26(13):3126-3134
pubmed: 32156749
AJR Am J Roentgenol. 2004 Apr;182(4):897-903
pubmed: 15039161
Transl Oncol. 2018 Aug;11(4):852-863
pubmed: 29753186
Curr Opin Immunol. 2015 Jun;34:75-82
pubmed: 25749511
Cell Mol Life Sci. 2020 Aug;77(16):3077-3083
pubmed: 31907561
Int J Biol Sci. 2012;8(1):1-14
pubmed: 22211100
Liver Int. 2008 Nov;28(9):1217-25
pubmed: 18397230
Int J Biochem Cell Biol. 2015 Mar;60:73-81
pubmed: 25562513
Pancreas. 2017 May/Jun;46(5):684-689
pubmed: 28196013
Pathol Int. 2012 Mar;62(3):167-75
pubmed: 22360504
Biochem Biophys Res Commun. 2013 Apr 26;434(1):95-101
pubmed: 23541946
Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S48-54
pubmed: 19896099
Cancer Microenviron. 2019 Apr;12(1):37-46
pubmed: 31025289
Cancer Res. 2017 Oct 15;77(20):5503-5517
pubmed: 28811332
Oncogene. 2016 Nov 3;35(44):5735-5745
pubmed: 27086923
Cancer Res. 2013 Oct 15;73(20):6359-74
pubmed: 24097820
Immunology. 2007 Jan;120(1):90-102
pubmed: 17073943
Biochem Soc Trans. 2013 Feb 1;41(1):263-7
pubmed: 23356294
PLoS Med. 2010 Apr 20;7(4):e1000267
pubmed: 20422030
Gut. 2022 Feb;71(2):441-443
pubmed: 33753418
J Cell Physiol. 2020 Apr;235(4):3928-3938
pubmed: 31608998
Cancer Chemother Pharmacol. 2011 Dec;68(6):1421-30
pubmed: 21479633
Surgery. 1999 Aug;126(2):371-7
pubmed: 10455908
Cancer Res. 1991 Feb 1;51(3):880-5
pubmed: 1988128
J Am Coll Surg. 2004 Jun;198(6):953-9
pubmed: 15194078
Br J Cancer. 2004 Oct 4;91(7):1316-26
pubmed: 15365564
Br J Cancer. 2010 Nov 23;103(11):1671-9
pubmed: 21045835
Anticancer Res. 2015 Jun;35(6):3129-35
pubmed: 26026072
Pancreas. 2013 Nov;42(8):1303-10
pubmed: 24152955
Mol Cell Proteomics. 2013 Feb;12(2):343-55
pubmed: 23161513
Nat Rev Clin Oncol. 2018 Apr;15(4):234-248
pubmed: 29405201
Cell Metab. 2019 Sep 3;30(3):403-404
pubmed: 31378465
Science. 2020 May 29;368(6494):973-980
pubmed: 32467386
Int J Cancer. 2014 Aug 15;135(4):843-61
pubmed: 24458546
Front Oncol. 2020 Dec 02;10:597672
pubmed: 33344246
FEBS J. 2018 Jun;285(11):2104-2124
pubmed: 29660229
Am J Transl Res. 2019 Jul 15;11(7):4470-4480
pubmed: 31396350
Bioessays. 2017 Jun;39(6):
pubmed: 28440551
Br J Cancer. 2013 Jul 23;109(2):502-11
pubmed: 23799850
Best Pract Res Clin Gastroenterol. 2010 Jun;24(3):349-58
pubmed: 20510834
Nature. 2003 Oct 23;425(6960):851-6
pubmed: 14520413
Cancer Biol Ther. 2015;16(1):43-51
pubmed: 25485960
Clin Immunol Immunopathol. 1993 Feb;66(2):91-106
pubmed: 8453790
Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1770-1782
pubmed: 29510195
Cancer Metastasis Rev. 2012 Jun;31(1-2):195-208
pubmed: 22101652
Front Immunol. 2019 Aug 02;10:1835
pubmed: 31428105
Gastrointest Tumors. 2014 Aug;1(3):123-34
pubmed: 26674754
Cancer Lett. 2016 Jan 28;370(2):302-12
pubmed: 26546047
Cancer. 2012 Jan 15;118(2):493-9
pubmed: 21598239
Cent Eur J Immunol. 2018;43(3):314-324
pubmed: 30588176
Mol Cancer. 2015 Oct 12;14:179
pubmed: 26458814
Cancer Res. 2011 Mar 1;71(5):1825-35
pubmed: 21343396
Mol Cancer. 2019 Nov 11;18(1):157
pubmed: 31711497
Oncogenesis. 2016 Apr 04;5:e216
pubmed: 27043662
Br J Cancer. 2013 Feb 5;108(2):361-9
pubmed: 23329235
Oncol Rep. 2018 Sep;40(3):1495-1502
pubmed: 29956804
Anticancer Res. 2008 Jul-Aug;28(4B):2205-12
pubmed: 18751396
Pancreas. 1987;2(1):14-24
pubmed: 3554225
Ann Oncol. 2021 Apr;32(4):478-487
pubmed: 33626377
J Hematol Oncol. 2015 Jul 10;8:83
pubmed: 26156517
DNA Cell Biol. 2020 Mar;39(3):417-427
pubmed: 31968179
J Pharmacol Sci. 2015 Mar;127(3):319-25
pubmed: 25837929
Gastroenterology. 2021 Apr;160(5):1771-1783.e1
pubmed: 33421513
Am J Cancer Res. 2020 Sep 01;10(9):3047-3060
pubmed: 33042633
Mol Carcinog. 2019 Jul;58(7):1291-1302
pubmed: 30968979
J Clin Oncol. 2008 Jun 10;26(17):2806-12
pubmed: 18539958
EBioMedicine. 2019 Feb;40:39-40
pubmed: 30765320
Scand J Gastroenterol. 2013 May;48(5):602-9
pubmed: 23477656
Front Immunol. 2021 Aug 13;12:691605
pubmed: 34484187
Cancer Biomark. 2018;22(1):169-174
pubmed: 29526843
Cancers (Basel). 2020 Jul 22;12(8):
pubmed: 32707920
Oncogene. 2009 Aug 13;28(32):2903-9
pubmed: 19543324
Dig Dis Sci. 2012 Dec;57(12):3160-7
pubmed: 23001407
Oncogene. 2005 Jun 23;24(27):4421-32
pubmed: 15856026
Mol Cancer. 2012 Sep 11;11:66
pubmed: 22966907
J Clin Pharm Ther. 2018 Apr;43(2):163-169
pubmed: 29214667
Cancer Res. 2018 Jan 1;78(1):205-215
pubmed: 29263152
Cell Death Dis. 2020 Sep 24;11(9):797
pubmed: 32973135
J Surg Res. 2012 Dec;178(2):758-67
pubmed: 22726648
Br J Cancer. 2021 Jan;124(2):333-344
pubmed: 32929194
Cancer Res. 2011 May 15;71(10):3453-8
pubmed: 21558392
Pharmacol Ther. 2016 Dec;168:29-42
pubmed: 27595930
Cancer Res. 2020 Nov 1;80(21):4768-4779
pubmed: 32900774
J Immunol. 1992 Dec 15;149(12):3809-16
pubmed: 1281188
World J Gastrointest Pathophysiol. 2013 Nov 15;4(4):74-90
pubmed: 24340225
Oncol Rep. 2015 Sep;34(3):1388-96
pubmed: 26135006
Saudi J Gastroenterol. 2019 Jan-Feb;25(1):3-13
pubmed: 30588953
J Pain Symptom Manage. 2013 Aug;46(2):e9-e13
pubmed: 23602326
Stem Cells Int. 2016;2016:5272498
pubmed: 26697077
Elife. 2020 Apr 09;9:
pubmed: 32270762
Cancer Chemother Pharmacol. 2006 Jan;57(2):165-70
pubmed: 16341905
Brain Res Bull. 2018 May;139:125-132
pubmed: 29438779
World J Surg. 2004 Aug;28(8):818-25
pubmed: 15457365
Arch Med Res. 2011 Jan;42(1):8-14
pubmed: 21376256
Lab Invest. 2013 Nov;93(11):1219-31
pubmed: 24042439
N Engl J Med. 2019 Jun 27;380(26):2518-2528
pubmed: 31112379
Cell Cycle. 2009 Jun 15;8(12):1860-4
pubmed: 19440048
Cell Stem Cell. 2007 Sep 13;1(3):313-23
pubmed: 18371365
Int J Mol Sci. 2020 Dec 22;22(1):
pubmed: 33375106
J Cancer. 2017 Jul 1;8(10):1744-1749
pubmed: 28819370
Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188418
pubmed: 32827581
Int J Oncol. 2015 Oct;47(4):1293-302
pubmed: 26252371
J Recept Signal Transduct Res. 2019 Oct-Dec;39(5-6):399-406
pubmed: 31875764
Mol Cancer Ther. 2009 Apr;8(4):809-20
pubmed: 19372554
Cancer Cell. 2017 Jul 10;32(1):71-87.e7
pubmed: 28697344
J Natl Compr Canc Netw. 2017 Aug;15(8):1063-1069
pubmed: 28784866
Biochem Pharmacol. 1995 Aug 8;50(4):451-7
pubmed: 7646549
Curr Med Chem. 2017;24(13):1321-1331
pubmed: 28176634
Cells. 2021 Jul 29;10(8):
pubmed: 34440697
Genes Dev. 2011 Apr 1;25(7):717-29
pubmed: 21406549
Cancers (Basel). 2021 Dec 09;13(24):
pubmed: 34944818
J Evid Based Integr Med. 2022 Jan-Dec;27:2515690X211068826
pubmed: 35018864
Cancers (Basel). 2021 Feb 09;13(4):
pubmed: 33572223
J Dermatol. 2011 Apr;38(4):345-53
pubmed: 21352343
Cancers (Basel). 2020 Jul 20;12(7):
pubmed: 32698524
Cancer Biol Ther. 2010 Oct 15;10(8):748-57
pubmed: 20703102
Curr Cancer Drug Targets. 2019;19(5):417-427
pubmed: 29714141
Oncogene. 2010 Jan 7;29(1):56-67
pubmed: 19784070
Pancreas. 2011 Jul;40(5):730-9
pubmed: 21633318
Sci Rep. 2018 Aug 10;8(1):12000
pubmed: 30097594
Gastroenterology. 2019 Sep;157(3):823-837
pubmed: 31078621
Clin Gastroenterol Hepatol. 2010 Sep;8(9):812-6
pubmed: 20570637
Mol Cancer Res. 2015 Mar;13(3):449-60
pubmed: 25368430
J Enzyme Inhib Med Chem. 2019 Dec;34(1):117-123
pubmed: 30362384
Cancer Cell. 2012 Jan 17;21(1):105-20
pubmed: 22264792
Int J Nanomedicine. 2018 Aug 29;13:4869-4880
pubmed: 30214194
J Gastroenterol. 2008;43(11):823-32
pubmed: 19012035
Gut. 2002 Apr;50(4):535-41
pubmed: 11889076
Trends Cancer. 2017 May;3(5):336-346
pubmed: 28718411
J Cell Biochem. 2001 Apr 2-27;82(1):110-22
pubmed: 11400168
Int J Clin Exp Med. 2015 Aug 15;8(8):12476-86
pubmed: 26550158
J Clin Invest. 2014 May;124(5):2125-35
pubmed: 24691445
Oncol Rep. 2011 Dec;26(6):1399-406
pubmed: 21922147
J Exp Clin Cancer Res. 2018 Nov 28;37(1):291
pubmed: 30486896
Cell Death Dis. 2015 Oct 15;6:e1913
pubmed: 26469962
Clin Cancer Res. 1999 Jan;5(1):119-27
pubmed: 9918209
Nat Rev Cancer. 2009 Sep;9(9):665-74
pubmed: 19693095
Int J Mol Sci. 2017 Jun 22;18(7):
pubmed: 28640192
Stem Cells. 2006 Apr;24(4):928-35
pubmed: 16306150
Medicine (Baltimore). 2016 Dec;95(49):e5541
pubmed: 27930550
Cancer Lett. 2014 Apr 10;345(2):203-9
pubmed: 23981573
Microbiol Rev. 1996 Jun;60(2):301-15
pubmed: 8801435
J Comput Chem. 2004 Jul 30;25(10):1286-94
pubmed: 15139041
Cancer Res. 2020 Apr 15;80(8):1624-1625
pubmed: 32295782
J Cancer Res Clin Oncol. 2010 Jun;136(6):897-903
pubmed: 19941148
Cancer Res. 2008 Oct 1;68(19):7707-10
pubmed: 18829522
Nature. 2008 Feb 28;451(7182):1111-5
pubmed: 18264088
J Pathol. 2016 Jul;239(3):286-96
pubmed: 27061193
Ann Oncol. 2012 Nov;23(11):2834-2842
pubmed: 22700995
Genes Dis. 2015 Jun 1;2(2):133-143
pubmed: 26114155
Anticancer Drugs. 2007 Apr;18(4):371-5
pubmed: 17351389
Eur J Pharm Sci. 2014 Jul 16;58:13-9
pubmed: 24613900
Nat Cell Biol. 2015 Feb;17(2):183-94
pubmed: 25621950
Tumour Biol. 2015 Mar;36(3):1375-84
pubmed: 25680410
Surgery. 2004 May;135(5):555-62
pubmed: 15118593
Br J Cancer. 2013 Jan 15;108(1):1-8
pubmed: 23299539
Clin Cancer Res. 2004 Apr 1;10(7):2299-306
pubmed: 15073105
Ann Oncol. 2006 May;17 Suppl 5:v7-12
pubmed: 16807468
Signal Transduct Target Ther. 2021 May 22;6(1):204
pubmed: 34023857
Cancer Sci. 2016 Dec;107(12):1818-1824
pubmed: 27685612
Genes Dev. 2006 Nov 15;20(22):3130-46
pubmed: 17114584
Cell Metab. 2019 Jun 4;29(6):1390-1399.e6
pubmed: 30827862
Mol Med Rep. 2015 Sep;12(3):3462-3468
pubmed: 26017562
Ther Adv Chronic Dis. 2019 Jul 18;10:2040622319862697
pubmed: 31367296
Clin Epigenetics. 2015 Dec 23;7:132
pubmed: 26705427
Cancer. 2015 Dec 15;121(24):4382-8
pubmed: 26440929
Phytomedicine. 2019 Jul;60:152998
pubmed: 31301971
Int J Cancer. 2006 Mar 15;118(6):1331-9
pubmed: 16381025
Cell. 2014 Sep 25;159(1):80-93
pubmed: 25259922
J Biol Chem. 2012 Jun 15;287(25):20866-75
pubmed: 22544745
Cell Physiol Biochem. 2018;47(4):1711-1720
pubmed: 29949790
Oncogene. 2014 Jul 17;33(29):3812-9
pubmed: 23995783
Oncol Rep. 2018 Mar;39(3):1347-1355
pubmed: 29328490
Lancet Oncol. 2016 Jun;17(6):801-810
pubmed: 27160474
Cell Death Dis. 2018 Oct 18;9(11):1065
pubmed: 30337520
Cancer Res. 2010 Jun 1;70(11):4528-38
pubmed: 20460539
Clin Cancer Res. 2005 May 15;11(10):3790-8
pubmed: 15897578
Mol Cancer Ther. 2007 Apr;6(4):1186-97
pubmed: 17406031
Cell. 2012 Jan 20;148(1-2):349-61
pubmed: 22265420
Cell Signal. 2014 Feb;26(2):179-85
pubmed: 24216611
Cancers (Basel). 2021 Jan 16;13(2):
pubmed: 33467099
Target Oncol. 2015 Jun;10(2):215-27
pubmed: 24950733
Cell. 2017 Jul 27;170(3):548-563.e16
pubmed: 28753429
World J Gastroenterol. 2018 Nov 21;24(43):4846-4861
pubmed: 30487695
Am J Transplant. 2002 Feb;2(2):111-9
pubmed: 12099512
Exp Mol Pathol. 2015 Feb;98(1):41-6
pubmed: 25481101
J Hematol Oncol. 2010 Nov 24;3:46
pubmed: 21106054
Acta Biomater. 2017 Feb;49:152-166
pubmed: 27916739
Cancer Lett. 2010 Jul 1;293(1):99-108
pubmed: 20137856
Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188461
pubmed: 33157162
Int J Cancer. 2007 Mar 15;120(6):1355-63
pubmed: 17131328
Life Sci. 2018 Sep 1;208:253-261
pubmed: 30053447
Evol Appl. 2020 Nov 04;13(10):2689-2703
pubmed: 33294017
Gut. 1997 Jan;40(1):1-4
pubmed: 9155566
Tumour Biol. 2015 Jan;36(1):111-9
pubmed: 25464861
Br J Cancer. 2005 Jan 31;92(2):209-11
pubmed: 15702078
Drug Discov Today. 2022 May;27(5):1404-1410
pubmed: 34952224
Diagnostics (Basel). 2021 Mar 20;11(3):
pubmed: 33804776
Biochem Pharmacol. 2011 Apr 1;81(7):950-6
pubmed: 21291869
PLoS One. 2019 Sep 6;14(9):e0221810
pubmed: 31490946
Biochim Biophys Acta. 2005 Nov 25;1756(2):97-101
pubmed: 16169155
Oncotarget. 2015 May 10;6(13):10853-67
pubmed: 25890497
Oncol Rep. 2005 Dec;14(6):1635-8
pubmed: 16273269
Cancer. 2012 Jun 15;118(12):3026-35
pubmed: 22020923
J Clin Oncol. 1997 Jun;15(6):2403-13
pubmed: 9196156
Cancers (Basel). 2019 Nov 27;11(12):
pubmed: 31783584
Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G729-36
pubmed: 16373424
Anticancer Res. 2015 May;35(5):2731-7
pubmed: 25964552
Immunol Lett. 2003 Oct 31;89(2-3):125-31
pubmed: 14556969
Clin Cancer Res. 2004 Oct 15;10(20):6956-61
pubmed: 15501974
Cancer Res. 2010 May 1;70(9):3606-17
pubmed: 20388782
Biochem Biophys Res Commun. 2019 Aug 27;516(3):606-612
pubmed: 31239153
Oncogene. 2000 Jun 8;19(25):2913-20
pubmed: 10871842
BMC Cancer. 2012 Jun 08;12:226
pubmed: 22681698
Cell Death Dis. 2013 Oct 10;4:e838
pubmed: 24113172
Cell Death Dis. 2021 May 14;12(5):490
pubmed: 33990544
Ann Oncol. 2005 Oct;16(10):1654-61
pubmed: 16085692
Mol Cancer. 2017 Jul 24;16(1):131
pubmed: 28738823
J Exp Clin Cancer Res. 2014 Sep 02;33:69
pubmed: 25178497
Clin Cancer Res. 2007 Aug 15;13(16):4769-76
pubmed: 17699854
Cancer Biol Ther. 2017 Dec 2;18(12):927-936
pubmed: 29053398
N Engl J Med. 2010 Apr 29;362(17):1605-17
pubmed: 20427809
Eur J Cancer. 2016 Apr;57:10-22
pubmed: 26851397
Eur J Cancer. 2003 Jul;39(10):1377-83
pubmed: 12826040
Anticancer Res. 2011 Oct;31(10):3171-80
pubmed: 21965724
Theranostics. 2018 May 11;8(12):3224-3236
pubmed: 29930725
Biomed Res Int. 2016;2016:1869304
pubmed: 28078281
Cancers (Basel). 2020 Sep 12;12(9):
pubmed: 32932616
Apoptosis. 2013 Jul;18(7):861-9
pubmed: 23463283
J Drug Metab Toxicol. 2011 Feb 2;2(107):1-10
pubmed: 21804948
Clin Cancer Res. 2017 Dec 15;23(24):7490-7497
pubmed: 28954784
Oncogene. 2003 May 22;22(21):3243-51
pubmed: 12761494
Cancers (Basel). 2021 Oct 13;13(20):
pubmed: 34680275
N Engl J Med. 2018 Dec 20;379(25):2395-2406
pubmed: 30575490
Gut. 2011 Jun;60(6):861-8
pubmed: 20966025
Pharmacol Res. 2019 Apr;142:58-69
pubmed: 30682425
Semin Oncol. 1995 Aug;22(4 Suppl 11):42-6
pubmed: 7481844
Gastroenterology. 2013 Jun;144(6):1241-8
pubmed: 23622133
Cancer Res. 2011 Jun 1;71(11):3792-801
pubmed: 21478294
Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):117-122
pubmed: 28302417
Cancer Cell. 2011 Apr 12;19(4):456-69
pubmed: 21481788
Pancreas. 2004 Oct;29(3):179-87
pubmed: 15367883
Oncotarget. 2015 Jan 30;6(3):1740-9
pubmed: 25638153
EBioMedicine. 2019 Feb;40:394-405
pubmed: 30709769
Mol Carcinog. 2019 Nov;58(11):1985-1997
pubmed: 31373074
Cancer Lett. 2020 Oct 10;490:20-30
pubmed: 32585413
J Surg Res. 2007 Aug;141(2):196-203
pubmed: 17583745
Eur J Med Chem. 2021 Dec 15;226:113825
pubmed: 34562854
Cell Commun Signal. 2014 Mar 26;12:20
pubmed: 24670043
Pancreas. 2020 Mar;49(3):393-407
pubmed: 32132518
FASEB J. 1994 Aug;8(11):854-61
pubmed: 7520879
Mol Carcinog. 2017 Jan;56(1):49-61
pubmed: 26878440
Gut. 2013 Jan;62(1):112-20
pubmed: 22466618
Sci Rep. 2017 Aug 30;7(1):10093
pubmed: 28855644
Exp Cell Res. 2019 Oct 1;383(1):111543
pubmed: 31374207
Gut. 1999 Apr;44(4):534-41
pubmed: 10075961
Clin Cancer Res. 2016 Nov 15;22(22):5592-5604
pubmed: 27267855
Theranostics. 2020 Mar 4;10(9):4088-4100
pubmed: 32226541
Oncogene. 2001 Feb 15;20(7):859-68
pubmed: 11314019
Int J Mol Sci. 2019 Feb 05;20(3):
pubmed: 30764482
World J Gastrointest Oncol. 2022 Jan 15;14(1):38-54
pubmed: 35116102
Oncotarget. 2017 Mar 21;8(12):19074-19088
pubmed: 27894105
Jpn J Cancer Res. 1996 Jun;87(6):641-9
pubmed: 8766529
BMC Cancer. 2012 Sep 24;12:421
pubmed: 22998595
J Ovarian Res. 2014 Oct 11;7:94
pubmed: 25304388
BMC Cancer. 2015 Feb 19;15:71
pubmed: 25884642
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15336-41
pubmed: 21873242
Int J Clin Exp Pathol. 2015 Jun 01;8(6):6724-31
pubmed: 26261555
Clin Cancer Res. 2008 Mar 1;14(5):1470-7
pubmed: 18316571
J Biomech Eng. 2017 Feb 1;139(2):
pubmed: 27760260
World J Gastroenterol. 2019 Apr 21;25(15):1797-1816
pubmed: 31057295
Semin Oncol. 2015 Feb;42(1):8-18
pubmed: 25726048
J Hepatobiliary Pancreat Sci. 2011 Sep;18(5):700-11
pubmed: 21451941
Pharmacology. 2021;106(3-4):143-153
pubmed: 32966993
Cancer Res. 2010 Sep 15;70(18):7114-24
pubmed: 20807812
Int J Cancer. 2015 Sep 1;137(5):1035-46
pubmed: 25604508
Gut. 2016 Jul;65(7):1165-74
pubmed: 26061593
Stem Cells Transl Med. 2015 Sep;4(9):1033-43
pubmed: 26136504
Curr Cancer Drug Targets. 2014;14(4):407-17
pubmed: 24575976
Mol Carcinog. 2016 Nov;55(11):1560-1572
pubmed: 26373617
Oncol Rep. 2007 May;17(5):1201-5
pubmed: 17390066
Cancer Chemother Pharmacol. 2013 Sep;72(3):669-82
pubmed: 23934321
Arch Med Res. 2014 Jan;45(1):15-20
pubmed: 24316112
J Med Chem. 2015 Feb 12;58(3):1053-63
pubmed: 25474320
Br J Cancer. 2013 May 28;108(10):2063-9
pubmed: 23591198
Oncotarget. 2016 Aug 30;7(35):57099-57116
pubmed: 27494859
Dig Dis Sci. 2016 Jun;61(6):1561-71
pubmed: 26738736
Gut. 1999 Jul;45(1):134-42
pubmed: 10369717
Mol Cancer. 2022 Jan 19;21(1):24
pubmed: 35045883
Oncotarget. 2018 Apr 17;9(29):20826-20837
pubmed: 29755693
Cancer Res. 2020 Mar 1;80(5):1088-1101
pubmed: 31915130
Annu Rev Pathol. 2008;3:157-88
pubmed: 18039136
Cancer Res. 2015 Jan 15;75(2):284-95
pubmed: 25488750
Mol Cancer Ther. 2002 Oct;1(12):989-97
pubmed: 12481421
J Cancer. 2019 Jul 23;10(18):4397-4407
pubmed: 31413760
J Biochem Mol Toxicol. 2021 Apr;35(4):e22708
pubmed: 33491255
Eur J Pharmacol. 2021 Jul 15;903:174147
pubmed: 33961871
J Cell Biochem. 2005 Jul 1;95(4):649-56
pubmed: 15849724
Phytomedicine. 2021 Oct;91:153711
pubmed: 34450377
N Engl J Med. 2013 Oct 31;369(18):1691-703
pubmed: 24131140
Mol Carcinog. 2011 Oct;50(10):804-10
pubmed: 21268134
Cancer Chemother Pharmacol. 2016 Feb;77(2):235-42
pubmed: 26740120
J Clin Diagn Res. 2016 Nov;10(11):XE01-XE05
pubmed: 28050491
PLoS One. 2012;7(2):e32232
pubmed: 22393391
Cell Prolif. 2019 May;52(3):e12605
pubmed: 30945363
Cancer Cell. 2020 Feb 10;37(2):168-182.e4
pubmed: 31983610
Cancer Lett. 2013 Jul 10;335(1):41-51
pubmed: 23402814
PLoS One. 2012;7(5):e37222
pubmed: 22666346
Science. 2017 Sep 15;357(6356):1156-1160
pubmed: 28912244
Clin Cancer Res. 2008 Sep 15;14(18):5646-8
pubmed: 18794070
Gastroenterol Res Pract. 2012;2012:781765
pubmed: 23125850
Front Physiol. 2014 Jan 21;4:407
pubmed: 24478710
J Exp Clin Cancer Res. 2019 Jul 8;38(1):294
pubmed: 31287009
J Surg Res. 1996 Jun;63(1):310-3
pubmed: 8661216
Exp Cell Res. 2018 Aug 1;369(1):120-128
pubmed: 29772221
Oncotarget. 2016 Aug 30;7(35):56395-56407
pubmed: 27486761
Clin Cancer Res. 2015 Aug 1;21(15):3561-8
pubmed: 25695692
Br J Cancer. 2009 Oct 6;101(7):1155-61
pubmed: 19738614
Sci Rep. 2017 Feb 15;7:42339
pubmed: 28198398
Cancer Res. 2003 May 15;63(10):2649-57
pubmed: 12750293
Pharmacol Res. 2020 Nov;161:105130
pubmed: 32818653
Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85
pubmed: 12098600
Biochim Biophys Acta. 2007 Jan;1772(1):66-71
pubmed: 17011172
Cancer Metastasis Rev. 2021 Mar;40(1):245-272
pubmed: 33423164
PLoS One. 2013 Sep 09;8(9):e73940
pubmed: 24040120
Ann Surg Oncol. 2014 May;21(5):1530-7
pubmed: 24473642
Cancer Res. 2008 Apr 1;68(7):2065-70
pubmed: 18381409
Cell Stem Cell. 2011 Nov 4;9(5):433-46
pubmed: 22056140
Am J Clin Oncol. 2011 Dec;34(6):597-602
pubmed: 21127410
Theranostics. 2017 Jul 22;7(12):3053-3067
pubmed: 28839463
J Clin Oncol. 2009 May 1;27(13):2231-7
pubmed: 19307500
Crit Care Med. 2016 Aug;44(8):e664-77
pubmed: 26963319
HPB (Oxford). 2020 Jun;22(6):821-832
pubmed: 32001139
Biochim Biophys Acta. 2007 Jul;1773(7):1095-106
pubmed: 17555830
Biomed Res Int. 2014;2014:817613
pubmed: 25147816
Pancreatology. 2015 Jul;15(4 Suppl):S32-8
pubmed: 25845856
Cancer Res. 2005 Dec 15;65(24):11510-9
pubmed: 16357160
Gastroenterology. 2014 Jan;146(1):245-56
pubmed: 24096005
Nat Cell Biol. 2015 Jun;17(6):816-26
pubmed: 25985394