Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment.
cell-of-origin
cytogenetics/FISH
diagnostics
diffuse large B-cell lymphoma
gene expression profiling
immunohistochemistry
minimum criteria for diagnosis
molecular
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
27 Apr 2022
27 Apr 2022
Historique:
received:
31
03
2022
revised:
23
04
2022
accepted:
24
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecular subtyping approach has continued to evolve simultaneously with others including immunohistochemistry and more modern genomic approaches. Recently, the veritable explosion of genomic data availability and evolving computational methodologies have provided additional avenues, by which further understanding and subclassification of DBLCLs is possible. The goal of this review is to provide a historical overview of the major classification timepoints in the molecular subtyping of DLBCL, from gene expression profiling to present day understanding.
Identifiants
pubmed: 35626243
pii: diagnostics12051087
doi: 10.3390/diagnostics12051087
pmc: PMC9139291
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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