Fracture Related Infections and Their Risk Factors for Treatment Failure-A Major Trauma Centre Perspective.
amputation
fracture
infection
polymicrobial infection
risk factor
trauma
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
22 May 2022
22 May 2022
Historique:
received:
22
04
2022
revised:
16
05
2022
accepted:
19
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Fracture related infections (FRI) are debilitating and costly complications of musculoskeletal trauma surgery that can result in permanent functional loss or amputation. Surgical treatment can be unsuccessful, and it is necessary to determine the predictive variables associated with FRI treatment failure, allowing one to optimise them prior to treatment and identify patients at higher risk. The clinical database at a major trauma centre was retrospectively reviewed between January 2015 and January 2021. FRI treatment failure was defined by infection recurrence or amputation. A univariable logistic regression analysis was performed, followed by a multivariable regression analysis for significant outcomes between groups on univariable analysis, to determine risk factors for treatment failure. In total, 102 patients were identified with a FRI (35 open, 67 closed fractures). FRI treatment failure occurred in 24 patients (23.5%). Risk factors determined by our multivariate logistic regression model were obesity (OR 2.522; 95% CI, 0.259-4.816;
Identifiants
pubmed: 35626444
pii: diagnostics12051289
doi: 10.3390/diagnostics12051289
pmc: PMC9141112
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Am J Emerg Med. 2012 Sep;30(7):1212-4
pubmed: 22169576
Wound Repair Regen. 2019 May;27(3):249-256
pubmed: 30663823
J Orthop Trauma. 2016 Oct;30(10):538-44
pubmed: 27124829
Lancet Infect Dis. 2011 Jan;11(1):14-5
pubmed: 21183146
J Arthroplasty. 2019 Apr;34(4):710-716.e3
pubmed: 30527896
J Bone Joint Surg Am. 1976 Jun;58(4):453-8
pubmed: 773941
J Orthop Trauma. 1999 Jun-Jul;13(5):369-72
pubmed: 10406705
Bone Joint J. 2014 Jun;96-B(6):783-8
pubmed: 24891579
PLoS Pathog. 2011 Mar;7(3):e1002012
pubmed: 21483753
J Clin Endocrinol Metab. 2016 Jun;101(6):2502-10
pubmed: 27115060
Injury. 2006 May;37 Suppl 2:S59-66
pubmed: 16651073
J Orthop Trauma. 2014 Jul;28(7):e153-9
pubmed: 24149446
J Bone Jt Infect. 2018 Jul 6;3(3):130-137
pubmed: 30013894
Am J Med. 2008 Jun;121(6):515-8
pubmed: 18501233
Eur J Trauma Emerg Surg. 2016 Aug;42(4):397-410
pubmed: 26886235
J Orthop Surg Res. 2018 Mar 15;13(1):53
pubmed: 29544509
Injury. 2021 Jun;52(6):1351-1355
pubmed: 33863501
PLoS One. 2019 Apr 8;14(4):e0215035
pubmed: 30958847
Curr Infect Dis Rep. 2018 Jun 6;20(8):23
pubmed: 29876674
Bone Joint J. 2021 Feb;103-B(2):213-221
pubmed: 33517743
Diabetes Care. 2003 Feb;26(2):510-3
pubmed: 12547890
J Bone Joint Surg Br. 2002 Nov;84(8):1093-110
pubmed: 12463652
J Trauma Acute Care Surg. 2014 Mar;76(3):730-5
pubmed: 24487318
J Orthop Res. 2002 Nov;20(6):1197-204
pubmed: 12472229
BMC Med Res Methodol. 2016 Nov 24;16(1):163
pubmed: 27881078
J Orthop Surg Res. 2017 Mar 9;12(1):41
pubmed: 28279223
Bone Joint Res. 2020 May 16;9(2):71-76
pubmed: 32435457
J Orthop Surg Res. 2018 Jun 8;13(1):145
pubmed: 29880016
JBI Database System Rev Implement Rep. 2015 Jan;13(1):253-303
pubmed: 26447018
J Orthop Trauma. 2007 Aug;21(7):507-11
pubmed: 17762489
Plast Reconstr Surg. 1991 Aug;88(2):311-8
pubmed: 1852825
Injury. 2021 Jan;52(1):43-52
pubmed: 32620328
J Bone Joint Surg Am. 2010 Apr;92(4):823-8
pubmed: 20360504
N Engl J Med. 2004 Apr 1;350(14):1422-9
pubmed: 15070792
Injury. 2013 Jul;44(7):1002-6
pubmed: 23561581
EFORT Open Rev. 2020 Oct 26;5(10):614-619
pubmed: 33204503
J Orthop. 2016 Oct 26;14(1):45-52
pubmed: 27822001
Clin Rheumatol. 2022 Aug;41(8):2513-2523
pubmed: 35366159
Bone Joint J. 2018 Dec;100-B(12):1542-1550
pubmed: 30499325
Clin Microbiol Infect. 2020 May;26(5):572-578
pubmed: 31446152
J Trauma. 1988 Jan;28(1):69-77
pubmed: 3123707
Int Orthop. 2016 Jul;40(7):1367-73
pubmed: 26183140
Arch Orthop Trauma Surg. 2019 Jan;139(1):61-72
pubmed: 30343322
mBio. 2013 Jul 23;4(4):
pubmed: 23882015
J Arthroplasty. 2013 Jun;28(6):899-903
pubmed: 23523496
Clin Infect Dis. 2007 Nov 1;45(9):1113-9
pubmed: 17918072
PLoS One. 2014 Jun 09;9(6):e99656
pubmed: 24911161
Ann Thorac Surg. 2011 Oct;92(4):1420-6
pubmed: 21958791
Clin Microbiol Rev. 2014 Apr;27(2):302-45
pubmed: 24696437
Immunology. 2015 Feb;144(2):171-85
pubmed: 25262977
Arch Orthop Trauma Surg. 2022 Jan 19;:
pubmed: 35043253
Chirurg. 2015 Oct;86(10):925-34
pubmed: 26296510
PLoS Negl Trop Dis. 2015 Aug 21;9(8):e0003976
pubmed: 26295162
Clin Microbiol Infect. 2015 Aug;21(8):786.e9-786.e17
pubmed: 25959106
Injury. 2018 Mar;49(3):511-522
pubmed: 27639601
Trauma Case Rep. 2021 Dec 23;37:100585
pubmed: 35005162
J Bone Joint Surg Am. 2007 Jan;89(1):33-8
pubmed: 17200307
Clin Orthop Relat Res. 2008 Feb;466(2):466-72
pubmed: 18196433
J Epidemiol Community Health. 2022 Jan;76(1):75-84
pubmed: 34326183
Unfallchirurgie. 1986 Oct;12(5):241-6
pubmed: 3798588
Clin Infect Dis. 2018 Nov 28;67(12):1878-1882
pubmed: 29746626
Int J Surg. 2013;11(5):383-8
pubmed: 23470598
Int J Obes (Lond). 2013 Mar;37(3):333-40
pubmed: 22546772
J Arthroplasty. 2018 Oct;33(10):3238-3245
pubmed: 29914821
Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1220-8
pubmed: 21900121
Br J Clin Pharmacol. 2000 Mar;49(3):223-30
pubmed: 10718777
BMJ. 1998 Sep 5;317(7159):652-4
pubmed: 9727997
BMC Infect Dis. 2018 Dec 7;18(1):635
pubmed: 30526540
PLoS One. 2010 Feb 05;5(2):e9085
pubmed: 20140211
Int Orthop. 2015 Jun;39(6):1159-66
pubmed: 25750130
J Bone Joint Surg Am. 1985 Oct;67(8):1236-44
pubmed: 3902846
Injury. 2014 Jul;45(7):1025-7
pubmed: 24794617
Injury. 2018 Mar;49(3):505-510
pubmed: 28867644
FEMS Microbiol Lett. 2005 Sep 15;250(2):271-7
pubmed: 16085371
J Orthop. 2015 Feb 17;12(Suppl 1):S37-43
pubmed: 26719627