Identification of the Transcriptional Biomarkers Panel Linked to Pathological Remodelling of the Eye Tissues in Various HD Mouse Models.

Animals Biomarkers Disease Models, Animal Eye Proteins Huntington Disease / metabolism Membrane Proteins Mice Mutant Proteins Neurodegenerative Diseases
Huntington’s disease biomarkers mouse models ocular neurodegeneration retina transcriptional deregulation

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
18 05 2022
Historique:
received: 18 03 2022
revised: 16 05 2022
accepted: 16 05 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 1 6 2022
Statut: epublish

Résumé

Ocular abnormalities are becoming associated with a spectrum of pathological events in various neurodegenerative diseases. Huntington's disease (HD) is just such an example of a fatal neurological disorder, where mutated genes (CAG trinucleotide expansions in the

Identifiants

DOI: 10.3390/cells11101675 PMID: 35626712 PMC: PMC9139483
pubmed: 35626712
pii: cells11101675
doi: 10.3390/cells11101675
pmc: PMC9139483
pii:
doi:

Substances chimiques

Biomarkers 0
Eye Proteins 0
Membrane Proteins 0
Mutant Proteins 0
REEP6 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Welcome Trust UK
ID : WT102944

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Auteurs

Iwona Mazur-Michałek (I)

Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Marcin Ruciński (M)

Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
ORCID: 0000-0002-2525-5777

Mateusz Sowiński (M)

Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
ORCID: 0000-0003-3258-9609

Paulina Pietras (P)

Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Marta Leśniczak-Staszak (M)

Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Witold Szaflarski (W)

Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
ORCID: 0000-0001-5059-268X

Mark Isalan (M)

Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.

Michal Mielcarek (M)

Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
ORCID: 0000-0002-9874-6753

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identification of the Transcriptional...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Identification of the Transcriptional...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Identification of the Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de l'oeil › Identification of the Transcriptional...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie de Huntington › Identification of the Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Identification of the Transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of the Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mutantes › Identification of the Transcriptional...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Identification of the Transcriptional...