Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)-A Narrative Review.
children
guidelines
inflammatory bowel disease
treatment
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
26 Apr 2022
26 Apr 2022
Historique:
received:
07
03
2022
revised:
19
04
2022
accepted:
22
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only has the role of biological agents become more important in the last decade in the treatment of children and adolescents, but also new insights into the composition of the gastrointestinal microbiome and personal diet implications have increased our understanding of the disease and opened up potential therapeutic pathways. This narrative review provides an overview of current recommendations, therapeutic options, drug monitoring, and practical guidelines for paediatricians involved with paediatric IBD patients. Furthermore, the off-label use of potential helpful drugs in the treatment of these patients is discussed.
Identifiants
pubmed: 35626795
pii: children9050617
doi: 10.3390/children9050617
pmc: PMC9140197
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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