Methylation Heterogeneity and Gene Expression of SPG20 in Solid Tumors.
DNA methylation
SPG20
gene expression regulation
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
12 05 2022
12 05 2022
Historique:
received:
22
04
2022
revised:
06
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
The downregulation of the Spastic Paraplegia-20 ( We analyzed the data generated through Infinium Human Methylation 450 BeadChip arrays and RNA-seq approaches extrapolated from The Cancer Genome Atlas (TCGA) database. The statistics were performed with R 4.0.4. We aimed to assess whether the hypermethylation of this target gene was a common characteristic among different tumors and if there was a correlation between the m-values and the gene expression in paired tumor versus solid tissue normal. Overall, our analysis highlighted that Our research, based on data mining from TCGA, evidences that colon and liver tumors display a consistent methylation heterogeneity compared to their normal counterparts. This parallels a downregulation of
Identifiants
pubmed: 35627246
pii: genes13050861
doi: 10.3390/genes13050861
pmc: PMC9140344
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Neurochem. 2009 Nov;111(4):1022-30
pubmed: 19765186
Oncol Rep. 2022 Jan;47(1):
pubmed: 34751409
Epigenetics. 2014 Mar;9(3):428-36
pubmed: 24362313
PLoS One. 2019 Jun 13;14(6):e0218338
pubmed: 31194837
BMC Biol. 2010 May 26;8:72
pubmed: 20504295
Microb Cell. 2017 Nov 30;4(12):411-422
pubmed: 29234670
Haematologica. 2006 Jan;91(1):56-63
pubmed: 16434371
Nat Rev Genet. 2012 Oct;13(10):679-92
pubmed: 22945394
Hepatology. 2015 Jun;61(6):1945-56
pubmed: 25645722
PLoS One. 2011 Apr 29;6(4):e19290
pubmed: 21559443
Am J Transl Res. 2021 Oct 15;13(10):11597-11607
pubmed: 34786085
Autophagy. 2022 Jan;18(1):50-72
pubmed: 33794741
Front Biosci (Landmark Ed). 2021 Sep 30;26(9):602-613
pubmed: 34590470
Biochem J. 2009 Sep 14;423(1):31-9
pubmed: 19580544
Nat Genet. 2013 May;45(5):478-86
pubmed: 23525077
Cell Rep. 2018 Oct 23;25(4):1066-1080.e8
pubmed: 30355485
Neuron. 2013 Feb 20;77(4):680-95
pubmed: 23439121
J Neurochem. 2006 Sep;98(6):1908-19
pubmed: 16945107
Oncogene. 2011 Sep 15;30(37):3967-78
pubmed: 21499309
Exp Cell Res. 2006 Sep 10;312(15):2764-77
pubmed: 16781711
Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417
pubmed: 29673586
JIMD Rep. 2017;33:55-60
pubmed: 27539578
Nat Genet. 2002 Aug;31(4):347-8
pubmed: 12134148
Mol Biol Cell. 2007 May;18(5):1683-92
pubmed: 17332501
J Cell Biol. 2009 Mar 23;184(6):881-94
pubmed: 19307600
Mutat Res Rev Mutat Res. 2019 Jan - Mar;779:45-57
pubmed: 31097151
Mol Cell Probes. 2015 Oct;29(5):315-8
pubmed: 26003402
Mol Biol Cell. 2010 Oct 1;21(19):3293-303
pubmed: 20719964
Gastroenterology. 2013 Dec;145(6):1424-35.e1-25
pubmed: 24012984
Cancer Biomark. 2022;34(2):221-250
pubmed: 34957998
Blood. 2015 Mar 19;125(12):1922-31
pubmed: 25612624
Cancer Genet. 2019 Apr;233-234:48-55
pubmed: 31109594
Leuk Res. 2017 Jun;57:89-96
pubmed: 28324774