Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial.
C-tactile
autonomic nervous system
heart rate variability
neonatal intensive care unit
osteopathic manipulative treatment
preterm infants
touch
Journal
Healthcare (Basel, Switzerland)
ISSN: 2227-9032
Titre abrégé: Healthcare (Basel)
Pays: Switzerland
ID NLM: 101666525
Informations de publication
Date de publication:
27 Apr 2022
27 Apr 2022
Historique:
received:
04
03
2022
revised:
21
04
2022
accepted:
25
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Osteopathic manipulative treatment (OMT) has been found to be effective in the context of premature infants. Nonetheless, no studies have investigated the immediate effects of OMT on heart rate variability (HRV). As altered HRV reflects poor or worsening newborn's clinical conditions and neurodevelopment, should OMT improve HRV fluctuations, it could become a relevant intervention for improving the care of preterm newborns. Therefore, this study aimed to evaluate whether OMT could affect HRV. The study was carried out at the Buzzi Hospital in Milan. From the neonatal intensive care unit, ninety-six preterm infants (41 males) were enrolled and were randomly assigned to one of two treatment groups: OMT or Static Touch. The infants were born at 33.5 weeks (±4.3) and had a mean birth weight of 2067 g (±929). The study had as primary outcome the change in the beat-to-beat variance in heart rate measured through root mean square of consecutive RR interval differences (RMSSD); other metrics were used as secondary and exploratory analyses. Despite the lack of statistically significant results regarding the primary outcomeand some study limitations, compared to static touch, OMT seemed to favor a parasympathetic modulation and improved HRV, which could reflect improvement in newborn's clinical conditions and development.
Identifiants
pubmed: 35627950
pii: healthcare10050813
doi: 10.3390/healthcare10050813
pmc: PMC9141319
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Evid Based Complement Alternat Med. 2014;2014:243539
pubmed: 25506381
Pediatrics. 2016 Jan;137(1):
pubmed: 26702029
J Neuroinflammation. 2016 May 10;13(1):103
pubmed: 27165310
Am J Perinatol. 2019 Apr;36(5):505-510
pubmed: 30193382
Physiol Behav. 2019 Aug 1;207:55-63
pubmed: 31047950
Dev Cogn Neurosci. 2019 Feb;35:47-56
pubmed: 29402735
J Manipulative Physiol Ther. 2021 May;44(4):319-329
pubmed: 33436300
Pflugers Arch. 2012 Dec;464(6):593-9
pubmed: 23053480
Acta Paediatr. 2019 Feb;108(2):258-265
pubmed: 29959869
Lancet. 2012 Jun 9;379(9832):2151-61
pubmed: 22579125
Front Neurosci. 2020 Sep 25;14:561186
pubmed: 33071738
Physiol Res. 2017 Sep 22;66(Suppl 2):S203-S214
pubmed: 28937235
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):179-88
pubmed: 12732233
Front Psychiatry. 2017 Sep 13;8:171
pubmed: 28959218
Sci Rep. 2019 Dec 27;9(1):20019
pubmed: 31882635
Front Neurosci. 2021 Jan 05;14:613378
pubmed: 33584178
Clin Auton Res. 2021 Jun;31(3):415-424
pubmed: 33718981
Semin Pediatr Neurol. 2018 Dec;28:29-37
pubmed: 30522725
Early Hum Dev. 2009 Sep;85(9):561-7
pubmed: 19505775
J Matern Fetal Neonatal Med. 2018 Oct;31(20):2763-2769
pubmed: 28707558
Complement Ther Clin Pract. 2020 May;39:101116
pubmed: 32379655
Front Neurosci. 2021 Sep 20;15:721605
pubmed: 34616274
Nurs Outlook. 2019 Mar - Apr;67(2):169-189
pubmed: 30611546
Heliyon. 2019 Mar 07;5(3):e01300
pubmed: 30899829
Med Hypotheses. 2009 Feb;72(2):143-6
pubmed: 19004563
PLoS One. 2017 Mar 10;12(3):e0173457
pubmed: 28282451
Physiol Meas. 2019 Jul 03;40(6):064002
pubmed: 31071684
Infant Behav Dev. 2020 Aug;60:101441
pubmed: 32603951
Front Psychol. 2016 May 23;7:743
pubmed: 27242642
Front Pediatr. 2020 Aug 06;8:432
pubmed: 32850545
IEEE Trans Biomed Eng. 2006 Jan;53(1):119-25
pubmed: 16402611
Sci Transl Med. 2013 Jan 16;5(168):168ra8
pubmed: 23325801
Clin Perinatol. 2016 Sep;43(3):395-407
pubmed: 27524443
Nurs Res. 1995 May-Jun;44(3):179-85
pubmed: 7761295
J Physiol Anthropol. 2019 Mar 13;38(1):3
pubmed: 30867063
Childs Nerv Syst. 2017 Jul;33(7):1053-1063
pubmed: 28501900
Biomed Eng Online. 2011 Oct 10;10:90
pubmed: 21985357
Clin Pediatr (Phila). 2010 Mar;49(3):258-70
pubmed: 19448128
Acta Paediatr. 2010 Aug;99(8):1145-9
pubmed: 20346075
Physiol Meas. 2019 Jul 01;40(6):065004
pubmed: 31091517
BMC Pediatr. 2019 Jul 19;19(1):242
pubmed: 31324176
Pediatr Res. 2017 Sep;82(3):438-443
pubmed: 28376079
PLoS One. 2019 May 17;14(5):e0215930
pubmed: 31100075
Chiropr Man Therap. 2014 May 09;22:18
pubmed: 24904746
Front Hum Neurosci. 2017 Jul 20;11:368
pubmed: 28775685
Pediatr Res. 2022 Jan;91(1):171-177
pubmed: 33654284
Arq Bras Cardiol. 2011 Jun;96(6):443-9
pubmed: 21584479
Acta Paediatr Suppl. 1994 Jun;397:9-18
pubmed: 7981480
Ann N Y Acad Sci. 2006 Nov;1088:361-72
pubmed: 17192580
Medicine (Baltimore). 2017 Mar;96(12):e6408
pubmed: 28328840
IEEE J Biomed Health Inform. 2020 Mar;24(3):681-692
pubmed: 31295130
Early Hum Dev. 2016 Aug;99:7-12
pubmed: 27372636
Clin Perinatol. 2010 Sep;37(3):581-98
pubmed: 20813272
Pediatr Res. 2019 Jan;85(2):120-126
pubmed: 30166644
Infant Behav Dev. 2017 Nov;49:83-86
pubmed: 28777974
Front Public Health. 2017 Sep 28;5:258
pubmed: 29034226
Pediatr Res. 2020 Jan;87(2):210-220
pubmed: 31377752
Neuron. 2014 May 21;82(4):737-55
pubmed: 24853935
Neurosci Biobehav Rev. 2020 Jun;113:77-87
pubmed: 32145222
Front Neurosci. 2020 Oct 07;14:579365
pubmed: 33117124
Front Neurosci. 2020 Aug 18;14:887
pubmed: 33013294
Dev Psychobiol. 2021 Jul;63(5):1521-1533
pubmed: 33521969
Front Neurosci. 2016 Mar 10;10:100
pubmed: 27013961
J Am Osteopath Assoc. 2017 Sep 01;117(9):559-567
pubmed: 28846122
Front Neurosci. 2021 Mar 22;15:650971
pubmed: 33828455
Front Physiol. 2012 Nov 30;3:450
pubmed: 23226132
Dev Psychobiol. 2021 Dec;63 Suppl 1:e22218
pubmed: 34964498
Behav Brain Res. 2016 Jan 15;297:37-40
pubmed: 26433145
Front Neurosci. 2015 Aug 04;9:272
pubmed: 26300719
Sci Rep. 2021 Feb 25;11(1):4556
pubmed: 33633195
J Pain. 2012 Jul;13(7):636-45
pubmed: 22595172
Neurosci Biobehav Rev. 2017 Jan;72:1-9
pubmed: 27845175
Sleep. 2012 Feb 01;35(2):177-86
pubmed: 22294807
J Matern Fetal Neonatal Med. 2016;29(15):2531-6
pubmed: 26440792
Front Integr Neurosci. 2013 Aug 08;7:57
pubmed: 23964209