The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems.
leptin
leptin receptor
metabolism
physiological functions
systemic role
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 May 2022
13 May 2022
Historique:
received:
30
03
2022
revised:
30
04
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Leptin is a well-known hunger-sensing peptide hormone. The role of leptin in weight gain and metabolic homeostasis has been explored for the past two decades. In this review, we have tried to shed light upon the impact of leptin signaling on health and diseases. At low or moderate levels, this peptide hormone supports physiological roles, but at chronically higher doses exhibits detrimental effects on various systems. The untoward effects we observe with chronically higher levels of leptin are due to their receptor-mediated effect or due to leptin resistance and are not well studied. This review will help us in understanding the non-anorexic roles of leptin, including their contribution to the metabolism of various systems and inflammation. We will be able to get an alternative perspective regarding the physiological and pathological roles of this mysterious peptide hormone.
Identifiants
pubmed: 35628271
pii: ijms23105439
doi: 10.3390/ijms23105439
pmc: PMC9141226
pii:
doi:
Substances chimiques
Leptin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Domest Anim Endocrinol. 2013 Nov;45(4):196-205
pubmed: 24209504
Clin Cancer Res. 2004 Jul 1;10(13):4325-31
pubmed: 15240518
Mol Cell Biochem. 2017 Sep;433(1-2):79-95
pubmed: 28343310
Am J Pathol. 2019 Mar;189(3):687-698
pubmed: 30610844
Reprod Biol. 2003 Nov;3(3):227-39
pubmed: 14688823
Breast Cancer Res. 2014 Oct 25;16(5):426
pubmed: 25482303
Metabolism. 2011 Sep;60(9):1227-33
pubmed: 21272901
Menopause. 2004 Jul-Aug;11(4):466-73
pubmed: 15243285
Mol Reprod Dev. 2008 May;75(5):874-80
pubmed: 17935159
Chin Med J (Engl). 2003 Jun;116(6):868-72
pubmed: 12877797
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):112-7
pubmed: 14615386
Bosn J Basic Med Sci. 2013 Aug;13(3):192-6
pubmed: 23988172
Eat Weight Disord. 2021 Jun;26(5):1399-1408
pubmed: 32578125
Nat Rev Nephrol. 2019 Jun;15(6):367-385
pubmed: 31015582
Prog Brain Res. 2006;153:325-37
pubmed: 16876584
Neuro Endocrinol Lett. 2005 Aug;26(4):297-300
pubmed: 16136023
Biochem Pharmacol. 2018 May;151:234-244
pubmed: 29288626
Metabolism. 2000 Dec;49(12):1537-41
pubmed: 11145113
Atherosclerosis. 2005 Nov;183(1):131-9
pubmed: 15950978
Antiinflamm Antiallergy Agents Med Chem. 2021;20(4):373-379
pubmed: 33888052
Biochem Pharmacol. 2021 May;187:114419
pubmed: 33460626
PLoS One. 2013 May 10;8(5):e64220
pubmed: 23675529
Eur J Endocrinol. 2010 Dec;163(6):873-8
pubmed: 20841449
J Urol. 2015 Jan;193(1):360-7
pubmed: 24980614
Biochimie. 2014 Oct;105:12-21
pubmed: 25010649
Endocrinology. 2001 Aug;142(8):3546-53
pubmed: 11459801
Cell Rep. 2019 Jan 8;26(2):346-355.e3
pubmed: 30625317
Mol Med Rep. 2019 Nov;20(5):4706-4712
pubmed: 31702041
Diabetologia. 1997 May;40(5):606-9
pubmed: 9165231
Am J Clin Nutr. 2000 Aug;72(2):484-9
pubmed: 10919945
Vitam Horm. 1998;54:1-30
pubmed: 9529971
Gen Comp Endocrinol. 2016 Apr 1;229:84-91
pubmed: 26853487
Int J Dev Neurosci. 2015 Jun;43:66-9
pubmed: 25862936
J Clin Invest. 2000 Aug;106(4):501-9
pubmed: 10953025
Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):97-105
pubmed: 11113536
Mol Med Rep. 2020 Feb;21(2):945-952
pubmed: 31789415
Kidney Int. 2006 Mar;69(5):794-7
pubmed: 16518340
Endocrinology. 1999 Nov;140(11):4939-47
pubmed: 10537117
J Clin Endocrinol Metab. 2005 Nov;90(11):6177-84
pubmed: 16144948
Bone. 2003 Nov;33(5):847-52
pubmed: 14623061
J Clin Endocrinol Metab. 2000 May;85(5):1954-62
pubmed: 10843181
Breast Cancer Res Treat. 2015 Jan;149(1):59-67
pubmed: 25481644
Biochem J. 2007 May 1;403(3):519-25
pubmed: 17286556
J Genet Genomics. 2021 Feb 20;48(2):134-146
pubmed: 33931338
Mol Metab. 2014 Aug 01;3(7):705-16
pubmed: 25352999
J Nutr Biochem. 2008 Sep;19(9):577-86
pubmed: 17911005
Br J Pharmacol. 2006 Sep;149(1):5-13
pubmed: 16847434
Diabetes. 2001 Feb;50(2):425-35
pubmed: 11272157
Nutrition. 2019 Nov - Dec;67-68:110556
pubmed: 31554603
Hypertension. 2016 May;67(5):970-6
pubmed: 27021010
J Am Heart Assoc. 2021 Sep 21;10(18):e022170
pubmed: 34482712
Gynecol Endocrinol. 2018 Jul;34(7):601-604
pubmed: 29268651
J Clin Endocrinol Metab. 2002 Jul;87(7):3110-7
pubmed: 12107209
Mol Cell Endocrinol. 2002 Feb 25;188(1-2):9-13
pubmed: 11911940
Anticancer Res. 2016 Dec;36(12):6279-6287
pubmed: 27919947
Proc R Soc Lond B Biol Sci. 1953 Jan 15;140(901):578-96
pubmed: 13027283
J Biol Chem. 1997 Dec 19;272(51):32686-95
pubmed: 9405487
Cell Metab. 2005 Dec;2(6):411-20
pubmed: 16330326
Horm Metab Res. 1996 Dec;28(12):724-7
pubmed: 9013751
Cardiovasc Res. 2017 Jul 1;113(9):1046-1054
pubmed: 28472252
PLoS One. 2012;7(1):e29389
pubmed: 22253718
Hepatology. 2001 Oct;34(4 Pt 1):694-706
pubmed: 11584365
Rocz Akad Med Bialymst. 2005;50:208-11
pubmed: 16358968
Prog Mol Biol Transl Sci. 2009;88:173-204
pubmed: 20374728
Trends Mol Med. 2016 Feb;22(2):88-98
pubmed: 26776093
Diabetologia. 2016 Jan;59(1):30-43
pubmed: 26407715
Int J Obes Relat Metab Disord. 2003 May;27(5):566-73
pubmed: 12704400
Acta Pharmacol Sin. 2018 Jul;39(7):1176-1188
pubmed: 29877321
Cell. 2000 Jan 21;100(2):197-207
pubmed: 10660043
Biochem J. 2006 Jan 1;393(Pt 1):7-20
pubmed: 16336196
Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):
pubmed: 28963115
Front Immunol. 2021 Nov 15;12:784823
pubmed: 34868066
Clin Exp Obstet Gynecol. 2003;30(4):207-10
pubmed: 14664414
Life Sci. 2001 Jul 20;69(9):987-1003
pubmed: 11508653
Diabetes. 1997 May;46(5):917-9
pubmed: 9133565
Int J Obes Relat Metab Disord. 1999 Jan;23(1):75-82
pubmed: 10094581
Gene. 2020 Aug 30;753:144812
pubmed: 32470507
Dis Model Mech. 2022 Jun 1;15(6):
pubmed: 35112705
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5150-5
pubmed: 15788534
Indian J Med Res. 2012 Apr;135(4):500-5
pubmed: 22664497
Mol Med Rep. 2018 May;17(5):7065-7072
pubmed: 29568885
J Neuroendocrinol. 2001 Dec;13(12):1066-75
pubmed: 11722703
Am J Obstet Gynecol. 2014 Mar;210(3):248.e1-9
pubmed: 24215851
Diabetes. 2015 May;64(5):1621-31
pubmed: 25409701
Leukemia. 2007 Mar;21(3):494-504
pubmed: 17252012
Eur J Histochem. 2018 Jan 26;62(1):2848
pubmed: 29569869
Exp Mol Med. 2001 Jun 30;33(2):95-102
pubmed: 11460888
Diabetes. 2001 Feb;50(2):348-52
pubmed: 11272146
Gen Pharmacol. 1998 Nov;31(5):799-801
pubmed: 9809481
Mediators Inflamm. 2016;2016:4036232
pubmed: 27721574
Neuroendocrinology. 2003 Nov;78(5):270-9
pubmed: 14657608
Reprod Biol. 2018 Mar;18(1):132-136
pubmed: 29454804
J Hepatol. 2002 Aug;37(2):206-13
pubmed: 12127425
FASEB J. 2003 Oct;17(13):1895-7
pubmed: 12923067
Br J Nutr. 2018 Mar;119(5):486-495
pubmed: 29508690
Gynecol Endocrinol. 2017 Apr;33(4):287-291
pubmed: 28010139
Front Integr Neurosci. 2013 Aug 23;7:62
pubmed: 23986664
Front Neurosci. 2019 Aug 07;13:828
pubmed: 31447640
Peptides. 2015 Nov;73:35-42
pubmed: 26297880
J Neurosci. 2004 Jun 2;24(22):5091-100
pubmed: 15175378
Miner Electrolyte Metab. 1999 Jul-Dec;25(4-6):298-302
pubmed: 10681655
Adv Exp Med Biol. 2013;756:155-61
pubmed: 22836631
Nutr J. 2018 Dec 28;17(1):118
pubmed: 30593267
Front Endocrinol (Lausanne). 2021 May 18;12:585887
pubmed: 34084149
Neuron. 1998 Dec;21(6):1375-85
pubmed: 9883730
Am J Physiol Regul Integr Comp Physiol. 2019 Sep 1;317(3):R451-R460
pubmed: 31314542
J Bone Miner Res. 2011 Jul;26(7):1506-16
pubmed: 21328617
Gut. 2000 Oct;47(4):481-6
pubmed: 10986207
Clin Exp Immunol. 2002 Jul;129(1):119-24
pubmed: 12100031
Scand J Gastroenterol. 1999 Oct;34(10):954-61
pubmed: 10563663
Cancer Prev Res (Phila). 2017 Apr;10(4):235-243
pubmed: 28270386
Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):653-66
pubmed: 12468413
Arthritis Rheum. 2012 Nov;64(11):3564-73
pubmed: 22833425
J Clin Invest. 2005 Dec;115(12):3484-93
pubmed: 16284652
Ann Nutr Metab. 2016;68(1):35-41
pubmed: 26588347
Vitam Horm. 2000;59:265-304
pubmed: 10714243
Atherosclerosis. 2006 Nov;189(1):47-60
pubmed: 16580676
J Neuroendocrinol. 2001 Jun;13(6):505-16
pubmed: 11412337
PLoS One. 2016 Sep 16;11(9):e0162845
pubmed: 27636369
Endocr Rev. 2021 Jan 28;42(1):1-28
pubmed: 33150398
Endocrinology. 2010 Jan;151(1):56-62
pubmed: 19966187
J Pediatr Endocrinol Metab. 2012;25(9-10):951-5
pubmed: 23426825
Metabolism. 2014 Oct;63(10):1272-9
pubmed: 25060689
Endocrinology. 1998 Sep;139(9):3681-90
pubmed: 9724018
J Cell Biochem. 2002;85(4):825-36
pubmed: 11968022
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec;151(2):195-9
pubmed: 18345251
Hypertens Res. 2018 Aug;41(8):629-638
pubmed: 29907861
J Neurochem. 2001 May;77(4):993-1000
pubmed: 11359864
J Immunol. 2015 Jun 1;194(11):5253-60
pubmed: 25917102
Acta Med Iran. 2010 Sep-Oct;48(5):300-3
pubmed: 21287461
Eur J Endocrinol. 2010 Jun;162(6):1075-82
pubmed: 20212016
Diabetes. 1997 Feb;46(2):313-6
pubmed: 9000710
J Neuroendocrinol. 2014 Jun;26(6):377-85
pubmed: 24698502
Ann N Y Acad Sci. 2001 Dec;947:134-41; discussion 141-2
pubmed: 11795261
Circ Res. 1998 Nov 16;83(10):1059-66
pubmed: 9815153
Yonsei Med J. 2000 Feb;41(1):68-75
pubmed: 10731922
Pituitary. 2000 Dec;3(4):211-20
pubmed: 11788008
J Biol Chem. 2003 Oct 31;278(44):43224-8
pubmed: 12917427
J Clin Endocrinol Metab. 2014 Sep;99(9):3460-7
pubmed: 24796929
Cell Metab. 2017 Dec 5;26(6):842-855.e5
pubmed: 29056512
Clin Cancer Res. 2006 Mar 1;12(5):1447-53
pubmed: 16533767
Obes Res. 2004 Sep;12(9):1492-8
pubmed: 15483214
Mol Cell Endocrinol. 2017 Jan 5;439:65-73
pubmed: 27793676
J Neuroendocrinol. 2002 Nov;14(11):887-93
pubmed: 12421342
Clin Exp Pharmacol Physiol. 2011 Dec;38(12):905-13
pubmed: 21957899
J Appl Physiol (1985). 2003 Feb;94(2):591-7
pubmed: 12391130
Inflammation. 2018 Mar;41(2):710-721
pubmed: 29322364
Int J Clin Exp Med. 2015 Nov 15;8(11):19840-9
pubmed: 26884894
Vitam Horm. 2005;71:345-72
pubmed: 16112274
J Cell Physiol. 2013 Jun;228(6):1202-9
pubmed: 23129404
J Int Med Res. 2008 Jan-Feb;36(1):96-105
pubmed: 18230273
Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R781-R790
pubmed: 29443548
Pol J Pharmacol. 2003 Sep-Oct;55(5):763-9
pubmed: 14704473
Diabetes. 1999 Feb;48(2):426-9
pubmed: 10334326
Ann Saudi Med. 2006 Mar-Apr;26(2):110-5
pubmed: 16761447
Endocrinology. 2000 Nov;141(11):3946-55
pubmed: 11089524
Gynecol Endocrinol. 2006 Apr;22(4):207-12
pubmed: 16723307
J Pediatr Endocrinol Metab. 2002 Mar;15(3):241-53
pubmed: 11924926
Ann Intern Med. 2010 Jan 19;152(2):93-100
pubmed: 20083828
Int J Colorectal Dis. 2007 Apr;22(4):401-9
pubmed: 16912864
Cell Immunol. 2000 Jan 10;199(1):15-24
pubmed: 10675271
Cell Tissue Res. 2021 Mar;383(3):1103-1122
pubmed: 33159578
Curr Drug Targets. 2019;20(15):1563-1571
pubmed: 31362672
Diabetes. 1997 Jun;46(6):1087-93
pubmed: 9166685
Neuropeptides. 2011 Oct;45(5):343-9
pubmed: 21821286
Curr Diabetes Rev. 2013 Jan 1;9(1):25-53
pubmed: 22974359
Biochem Biophys Res Commun. 1997 Sep 29;238(3):851-5
pubmed: 9325180
Mol Pharm. 2021 Jun 7;18(6):2438-2447
pubmed: 33939443
Lab Invest. 1997 Sep;77(3):243-56
pubmed: 9314948
FASEB J. 2001 Jul;15(9):1529-38
pubmed: 11427484
Clin Exp Immunol. 2008 Mar;151(3):505-18
pubmed: 18234059
J Lipid Res. 2015 Jan;56(1):70-80
pubmed: 25395359
Biol Pharm Bull. 2014;37(1):169-73
pubmed: 24389492
Blood. 1999 Mar 1;93(5):1668-76
pubmed: 10029596
PLoS One. 2014 Jun 12;9(6):e99187
pubmed: 24922063
PLoS One. 2015 Mar 23;10(3):e0121242
pubmed: 25799398
Blood. 1997 Mar 1;89(5):1507-12
pubmed: 9057630
Int J Mol Sci. 2021 Apr 28;22(9):
pubmed: 33925217
J Endocrinol. 2001 Aug;170(2):413-23
pubmed: 11479137
Eur Cytokine Netw. 2000 Mar;11(1):7-14
pubmed: 10705294
J Cell Mol Med. 2018 Apr;22(4):2098-2109
pubmed: 29372627
J Biol Chem. 2001 Dec 28;276(52):49066-76
pubmed: 11551957
Heliyon. 2021 Nov 26;7(11):e08491
pubmed: 34901513
J Bone Miner Res. 2006 Oct;21(10):1591-9
pubmed: 16995814
Cell Mol Immunol. 2009 Oct;6(5):353-60
pubmed: 19887048
Obesity (Silver Spring). 2009 Dec;17(12):2149-54
pubmed: 19444224
PLoS One. 2014 Jul 17;9(7):e101984
pubmed: 25033454
Pituitary. 2001 Jan-Apr;4(1-2):15-23
pubmed: 11824504
Cancer. 2017 Jul 1;123(13):2413-2421
pubmed: 28195643
Obes Rev. 2015 Mar;16(3):207-24
pubmed: 25589226
Clin Endocrinol (Oxf). 2002 Nov;57(5):643-6
pubmed: 12390339
Autophagy. 2021 Jul;17(7):1571-1591
pubmed: 32627660
Cancer Res. 2004 Aug 15;64(16):5870-5
pubmed: 15313931
Endocrinology. 2000 Jun;141(6):1955-61
pubmed: 10830277
Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):200-6
pubmed: 19910644
J Immunol. 2005 Jun 1;174(11):6820-8
pubmed: 15905523
Int J Mol Sci. 2020 Dec 09;21(24):
pubmed: 33316927
J Cereb Blood Flow Metab. 2013 Jun;33(6):944-53
pubmed: 23462572
Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E695-702
pubmed: 15886225
Prog Lipid Res. 2004 Jul;43(4):283-301
pubmed: 15234549
Metabolism. 2015 Jan;64(1):105-13
pubmed: 25497343
Endocr Rev. 2018 Dec 1;39(6):938-959
pubmed: 30184053
Biochem Soc Trans. 2007 Feb;35(Pt 1):33-6
pubmed: 17212584
Timely Top Med Cardiovasc Dis. 2005 Dec 01;9:E34
pubmed: 16404479
J Clin Invest. 2001 Nov;108(10):1533-40
pubmed: 11714745
Stem Cell Rev Rep. 2021 Apr;17(2):511-522
pubmed: 33598894
Eur J Med Res. 2010 Nov 4;15 Suppl 2:50-4
pubmed: 21147620
Diabetes. 2010 Dec;59(12):3032-40
pubmed: 20876720
EBioMedicine. 2018 Jun;32:43-49
pubmed: 29885866
Br J Haematol. 1998 Aug;102(3):740-5
pubmed: 9722301
Ann Rheum Dis. 2012 Mar;71(3):455-62
pubmed: 22072016
J Biol Chem. 2002 Sep 13;277(37):34117-24
pubmed: 12114517
Endocrinology. 2009 Jun;150(6):2805-12
pubmed: 19179437
Eur J Contracept Reprod Health Care. 2009 Apr;14(2):153-9
pubmed: 19340711
J Immunol. 2014 Jan 1;192(1):136-44
pubmed: 24273001
J Cell Physiol. 2018 Dec;233(12):9159-9166
pubmed: 29943829
J Med Life. 2021 Sep-Oct;14(5):600-605
pubmed: 35027962
Annu Rev Physiol. 2015;77:131-60
pubmed: 25668019
PLoS One. 2011 Apr 18;6(4):e18823
pubmed: 21533119
J Immunol. 2006 Jun 15;176(12):7745-52
pubmed: 16751422
Eur J Endocrinol. 2004 May;150(5):691-8
pubmed: 15132726
Brain Res. 2015 Apr 16;1604:62-73
pubmed: 25665530
Neuroendocrinology. 2016;103(3-4):402-7
pubmed: 26336809
Nature. 1998 Aug 27;394(6696):897-901
pubmed: 9732873
Endocrinology. 2003 Sep;144(9):3789-98
pubmed: 12933650
Endocrinology. 2005 May;146(5):2157-64
pubmed: 15677756