Osteoimmunology in Periodontitis: Local Proteins and Compounds to Alleviate Periodontitis.
RANKL
bone regeneration
immune cells
osteocytes
osteoimmunology
periodontitis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 May 2022
16 May 2022
Historique:
received:
16
04
2022
revised:
13
05
2022
accepted:
14
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Periodontitis is one of the most common oral diseases resulting in gingival inflammation and tooth loss. Growing evidence indicates that it results from dysbiosis of the oral microbiome, which interferes with the host immune system, leading to bone destruction. Immune cells activate periodontal ligament cells to express the receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL) and promote osteoclast activity. Osteocytes have active roles in periodontitis progression in the bone matrix. Local proteins are involved in bone regeneration through functional immunological plasticity. Here, we discuss the current knowledge of cellular and molecular mechanisms in periodontitis, the roles of local proteins, and promising synthetic compounds generating a periodontal regeneration effect. It is anticipated that this may lead to a better perception of periodontitis pathophysiology.
Identifiants
pubmed: 35628348
pii: ijms23105540
doi: 10.3390/ijms23105540
pmc: PMC9146968
pii:
doi:
Substances chimiques
NF-kappa B
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19H03828
Organisme : Japan Society for the Promotion of Science
ID : 22H03267
Organisme : Takeda Science Foundation
ID : J20G0093
Organisme : Uehara Memorial Foundation
ID : J20G0163
Organisme : Nakatomi Foundation
ID : J20G0173
Organisme : Japan Agency for Medical Research and Development
ID : Interstellar Initiative
Organisme : Terumo Life Science Foundation
ID : J20G0162
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