Analysis of Huntington's Disease Modifiers Using the Hyperbolic Mapping of the Protein Interaction Network.
Huntington’s disease
paralogy
protein–protein interaction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 May 2022
23 May 2022
Historique:
received:
28
04
2022
revised:
19
05
2022
accepted:
19
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Huntington's disease (HD) is caused by the production of a mutant huntingtin (HTT) with an abnormally long poly-glutamine (polyQ) tract, forming aggregates and inclusions in neurons. Previous work by us and others has shown that an increase or decrease in polyQ-triggered aggregates can be passive simply due to the interaction of proteins with the aggregates. To search for proteins with active (functional) effects, which might be more effective in finding therapies and mechanisms of HD, we selected among the proteins that interact with HTT a total of 49 pairs of proteins that, while being paralogous to each other (and thus expected to have similar passive interaction with HTT), are located in different regions of the protein interaction network (suggesting participation in different pathways or complexes). Three of these 49 pairs contained members with opposite effects on HD, according to the literature. The negative members of the three pairs, MID1, IKBKG, and IKBKB, interact with PPP2CA and TUBB, which are known negative factors in HD, as well as with HSP90AA1 and RPS3. The positive members of the three pairs interact with HSPA9. Our results provide potential HD modifiers of functional relevance and reveal the dynamic aspect of paralog evolution within the interaction network.
Identifiants
pubmed: 35628660
pii: ijms23105853
doi: 10.3390/ijms23105853
pmc: PMC9144261
pii:
doi:
Substances chimiques
IKBKG protein, human
0
I-kappa B Kinase
EC 2.7.11.10
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Biol Chem. 2014 Jan 24;289(4):2195-204
pubmed: 24324263
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
J Cell Biol. 2001 Apr 16;153(2):283-94
pubmed: 11309410
Hum Mol Genet. 1999 Sep;8(9):1647-55
pubmed: 10441327
PLoS Genet. 2009 Mar;5(3):e1000414
pubmed: 19293945
PLoS One. 2010 Jan 26;5(1):e8905
pubmed: 20126661
Cell. 1993 Mar 26;72(6):971-83
pubmed: 8458085
Life (Basel). 2016 Sep 08;6(3):
pubmed: 27618105
PLoS One. 2010 Feb 24;5(2):e9289
pubmed: 20195357
Hum Mol Genet. 2014 Nov 15;23(22):5928-39
pubmed: 24951540
Redox Biol. 2020 May;32:101458
pubmed: 32145456
Cell. 1997 Dec 12;91(6):753-63
pubmed: 9413985
J Biol Chem. 2005 Oct 14;280(41):34840-8
pubmed: 16091361
Hum Mol Genet. 2020 Aug 29;29(15):2596-2610
pubmed: 32681165
PLoS One. 2009 Jun 02;4(6):e5768
pubmed: 19488402
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10809-E10818
pubmed: 29162692
Front Cell Neurosci. 2016 Oct 07;10:226
pubmed: 27774050
Trends Genet. 2004 Mar;20(3):146-54
pubmed: 15036808
Cell Rep. 2014 Nov 6;9(3):1135-50
pubmed: 25437566
PLoS Genet. 2012;8(8):e1002897
pubmed: 22916034
Nat Neurosci. 2016 Apr;19(4):623-33
pubmed: 26900923
Mol Cell. 2014 Jul 3;55(1):15-30
pubmed: 24882209
Brain Behav Immun. 2011 Jun;25 Suppl 1:S29-38
pubmed: 21195164
iScience. 2022 Jan 19;25(2):103771
pubmed: 35146388
Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Sep;82(3 Pt 2):036106
pubmed: 21230138
J Neurosci. 2010 Oct 27;30(43):14318-29
pubmed: 20980587
PLoS One. 2012;7(2):e31826
pubmed: 22348130
Nature. 2012 Sep 27;489(7417):537-40
pubmed: 22972194
Sci Rep. 2016 Jul 22;6:30108
pubmed: 27445157
Nat Cell Biol. 2004 Feb;6(2):97-105
pubmed: 14743216
Hum Mol Genet. 2010 Nov 15;19(22):4437-52
pubmed: 20817635
Science. 2001 Mar 23;291(5512):2423-8
pubmed: 11264541
Autophagy. 2020 Nov;16(11):1989-2003
pubmed: 31964216
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1294-8
pubmed: 19878659
Biochim Biophys Acta. 2013 Dec;1833(12):2943-2952
pubmed: 23911537
Appl Netw Sci. 2016;1(1):10
pubmed: 30533502
Trends Genet. 2007 Jun;23(6):266-9
pubmed: 17428571
J Immunol. 2013 Feb 15;190(4):1797-806
pubmed: 23303669
Front Genet. 2021 Oct 01;12:761714
pubmed: 34659371
Genes (Basel). 2020 Sep 25;11(10):
pubmed: 32992839
J Neurosci. 2004 Sep 15;24(37):7999-8008
pubmed: 15371500
Brain Res Bull. 2014 Mar;102:57-68
pubmed: 24582883
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18754-9
pubmed: 18000063
Genome Res. 2003 Nov;13(11):2444-9
pubmed: 14559779
DNA Repair (Amst). 2007 Oct 1;6(10):1453-62
pubmed: 17560175
Bioessays. 2013 Jun;35(6):503-7
pubmed: 23483542
Cell Rep. 2020 Aug 18;32(7):108050
pubmed: 32814053
Appl Netw Sci. 2018;3(1):10
pubmed: 30839777
Nat Commun. 2013;4:1511
pubmed: 23443539
Nucleic Acids Res. 2017 Jan 4;45(D1):D408-D414
pubmed: 27794551
PLoS Genet. 2007 May 11;3(5):e82
pubmed: 17500595
Mol Cell. 2014 Jul 3;55(1):1-3
pubmed: 24996060
Bioinformatics. 2018 Aug 15;34(16):2826-2834
pubmed: 29635317
Neurosci Lett. 2008 Apr 4;434(3):241-6
pubmed: 18329171
Trends Biochem Sci. 2003 Aug;28(8):425-33
pubmed: 12932731
PLoS Biol. 2018 Dec 26;16(12):e2006838
pubmed: 30586380
Sci Rep. 2020 May 18;10(1):8130
pubmed: 32424160
J Mol Biol. 2012 Nov 23;424(1-2):1-14
pubmed: 22999956
PLoS Genet. 2008 Nov;4(11):e1000266
pubmed: 19023407
Nat Struct Mol Biol. 2004 Dec;11(12):1215-22
pubmed: 15543156
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Aug;92(2):022807
pubmed: 26382454
J Neurosci. 2008 Aug 27;28(35):8747-55
pubmed: 18753376
Oncotarget. 2017 Aug 23;8(46):80770-80789
pubmed: 29113343
Int J Mol Sci. 2021 Feb 09;22(4):
pubmed: 33572172
Nucleic Acids Res. 2022 Jan 7;50(D1):D988-D995
pubmed: 34791404
J Biol Chem. 2006 Jun 9;281(23):16147-56
pubmed: 16569640
F1000Res. 2015 May 01;4:103
pubmed: 26949515
J Neurosci. 1999 Dec 1;19(23):10338-47
pubmed: 10575031
Nat Cell Biol. 2006 Oct;8(10):1163-70
pubmed: 16980958
Hum Mol Genet. 2009 Oct 15;18(20):3942-54
pubmed: 19628478
Sci STKE. 2006 Oct 17;2006(357):re13
pubmed: 17047224
Science. 1997 Sep 26;277(5334):1990-3
pubmed: 9302293
J Biol Chem. 2020 May 22;295(21):7301-7316
pubmed: 32284329
Mol Biol Evol. 2001 Jul;18(7):1283-92
pubmed: 11420367
Phys Life Rev. 2018 Mar;24:162-167
pubmed: 29398557
J Neurochem. 2000 Feb;74(2):443-56
pubmed: 10646495
J Neurochem. 2005 Oct;95(1):125-36
pubmed: 16181417
Autophagy. 2015 Apr 3;11(4):685-700
pubmed: 25484089