Gram-Level Production of Balanol through Regulatory Pathway and Medium Optimization in Herb Fungus

Tolypocladium ophioglossoides Zn2Cys6 balanol biosynthesis fermentation medium optimization protein kinase C inhibitor regulator BlnR

Journal

Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827

Informations de publication

Date de publication:
16 May 2022
Historique:
received: 19 04 2022
revised: 08 05 2022
accepted: 12 05 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 29 5 2022
Statut: epublish

Résumé

As a potential protein kinase C inhibitor, the fungus metabolite balanol has become more attractive in recent decades. In our previous work, we revealed its biosynthetic pathway through overexpression of the cluster-situated regulator gene

Identifiants

pubmed: 35628765
pii: jof8050510
doi: 10.3390/jof8050510
pmc: PMC9143294
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : the National Key R&D Program of China
ID : "2018YFA0903200" and "2021YFC2100600"

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Auteurs

Rui-Qi Li (RQ)

School of Medicine and the Children's Hospital, Zhejiang University, Hangzhou 310058, China.
Institute of Pharmaceutical Biotechnology, Zhejiang University, Hangzhou 310058, China.

Xiang Liu (X)

School of Medicine and the Children's Hospital, Zhejiang University, Hangzhou 310058, China.
Institute of Pharmaceutical Biotechnology, Zhejiang University, Hangzhou 310058, China.

Min Zhang (M)

School of Medicine and the Children's Hospital, Zhejiang University, Hangzhou 310058, China.
Institute of Pharmaceutical Biotechnology, Zhejiang University, Hangzhou 310058, China.

Wei-Qun Xu (WQ)

School of Medicine and the Children's Hospital, Zhejiang University, Hangzhou 310058, China.

Yong-Quan Li (YQ)

Institute of Pharmaceutical Biotechnology, Zhejiang University, Hangzhou 310058, China.

Xin-Ai Chen (XA)

School of Medicine and the Children's Hospital, Zhejiang University, Hangzhou 310058, China.
Institute of Pharmaceutical Biotechnology, Zhejiang University, Hangzhou 310058, China.

Classifications MeSH