Extranodal Natural Killer/T-Cell Lymphomas: Current Approaches and Future Directions.
Epstein-Barr virus
brentuximab
daratumumab
extranodal NK/T-cell
programmed death receptor
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
10 May 2022
10 May 2022
Historique:
received:
16
01
2022
revised:
13
04
2022
accepted:
29
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Extranodal natural killer/T(NK/T)-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma that typically presents with an isolated nasal mass, but a sizeable minority present with advanced stage disease and have a significantly poorer prognosis. Those with limited disease are standardly treated with chemotherapy and radiation while those with advanced stage disease are treated with L-asparaginase containing chemotherapy regimens. The addition of modern radiation therapy techniques and the incorporation of L-asparaginase into chemotherapy regimens have significantly improved outcomes in this disease, but relapses and death from relapsed disease remain frequent. Given the high rate of relapse, several novel therapies have been evaluated for the treatment of this disease. In this review, we explore the current standard of care for ENKTL as well as novel therapies that have been evaluated for its treatment and the biologic understanding behind these therapies.
Identifiants
pubmed: 35628826
pii: jcm11102699
doi: 10.3390/jcm11102699
pmc: PMC9145443
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Cancer Res Treat. 2019 Apr;51(2):611-622
pubmed: 30025443
Clin Cancer Res. 2012 Mar 15;18(6):1611-8
pubmed: 22271878
Leuk Lymphoma. 2016 Nov;57(11):2575-83
pubmed: 27183991
Blood Res. 2015 Dec;50(4):254-6
pubmed: 26770954
Ann Hematol. 2017 Jan;96(1):25-31
pubmed: 27696202
Am J Pathol. 2017 May;187(5):980-986
pubmed: 28284718
Hum Pathol. 1999 Jul;30(7):849-55
pubmed: 10414505
Clin Lymphoma Myeloma Leuk. 2018 Jan;18(1):e41-e50
pubmed: 29277360
Exp Ther Med. 2016 Jun;11(6):2437-2445
pubmed: 27313673
Clin Lymphoma Myeloma Leuk. 2020 Sep;20(9):572-587
pubmed: 32331971
Blood. 2018 Feb 22;131(8):888-898
pubmed: 29233821
Blood. 2009 Apr 23;113(17):3931-7
pubmed: 19029440
Cancer. 2013 Jan 15;119(2):348-55
pubmed: 22811078
Front Immunol. 2020 Nov 30;11:597959
pubmed: 33329591
Oncotarget. 2016 Dec 20;7(51):85584-85591
pubmed: 27542213
Radiat Oncol. 2017 Apr 27;12(1):76
pubmed: 28449713
N Engl J Med. 2016 Oct 13;375(15):1501-1502
pubmed: 27732828
J Immunol. 2003 Jun 15;170(12):5993-8
pubmed: 12794126
Ann Hematol. 2018 Jan;97(1):193-196
pubmed: 28879531
Biochem J. 2012 Mar 15;442(3):465-81
pubmed: 22364281
J Immunol. 2001 Oct 15;167(8):4450-7
pubmed: 11591771
J Hematol Oncol. 2017 Apr 14;10(1):85
pubmed: 28410601
Chin J Cancer. 2017 May 10;36(1):43
pubmed: 28486951
J Clin Oncol. 1998 Jan;16(1):70-7
pubmed: 9440725
J Hematol Oncol. 2021 Feb 15;14(1):25
pubmed: 33588922
Blood. 2021 Dec 30;138(26):2828-2837
pubmed: 34653242
Blood. 2014 May 15;123(20):3095-100
pubmed: 24652992
J Hematol Oncol. 2018 Dec 20;11(1):140
pubmed: 30567593
DNA Repair (Amst). 2018 Sep;69:63-72
pubmed: 30075372
Int J Cancer. 1995 Jan 27;60(3):315-20
pubmed: 7829236
J Clin Oncol. 2012 Nov 10;30(32):4044-6
pubmed: 23045573
Blood. 2015 Sep 17;126(12):1424-32; quiz 1517
pubmed: 26109206
Ann Hematol. 2015 Aug;94(8):1381-8
pubmed: 25865943
Cytometry B Clin Cytom. 2020 Jan;98(1):28-35
pubmed: 31313887
Pediatr Blood Cancer. 2016 Apr;63(4):727-30
pubmed: 26727971
Biol Blood Marrow Transplant. 2008 Dec;14(12):1356-64
pubmed: 19041057
Oncotarget. 2016 Aug 23;7(34):55721-55731
pubmed: 27384676
J Clin Oncol. 2008 Sep 1;26(25):4124-30
pubmed: 18626005
J Clin Oncol. 2003 Sep 15;21(18):3526-34
pubmed: 12972530
Blood. 2004 Jul 1;104(1):243-9
pubmed: 15031209
J Exp Med. 1998 May 4;187(9):1395-402
pubmed: 9565632
Blood Res. 2020 Jul 31;55(S1):S63-S71
pubmed: 32719179
Am J Clin Pathol. 2012 Sep;138(3):435-47
pubmed: 22912362
Expert Rev Anticancer Ther. 2017 Aug;17(8):759-768
pubmed: 28621166
Nat Rev Mol Cell Biol. 2010 May;11(5):329-41
pubmed: 20379207
J Virol. 1986 Mar;57(3):1016-22
pubmed: 3005608
J Clin Oncol. 2011 Nov 20;29(33):4410-6
pubmed: 21990393
Hematol Oncol. 2018 Oct;36(4):713-714
pubmed: 30074631
Oncotarget. 2017 Oct 31;8(57):97516-97527
pubmed: 29228628
Blood. 2018 Feb 22;131(8):877-887
pubmed: 29191916
Int J Cancer. 1996 Nov 4;68(3):285-90
pubmed: 8903467
Ann Hematol. 2021 Oct;100(10):2529-2539
pubmed: 34304287
Blood. 2017 Apr 27;129(17):2437-2442
pubmed: 28188133
J Gen Virol. 2013 May;94(Pt 5):1127-1133
pubmed: 23303827
Clin Cancer Res. 2009 Apr 15;15(8):2905-12
pubmed: 19318493
Hematol Oncol. 2018 Feb;36(1):166-173
pubmed: 29052238
Blood. 2011 Dec 1;118(23):6018-22
pubmed: 21984805
J Immunol. 2009 Mar 15;182(6):3892-901
pubmed: 19265169
Blood. 2018 Jun 7;131(23):2528-2540
pubmed: 29602763
J Clin Oncol. 2006 Feb 1;24(4):612-8
pubmed: 16380410
Orphanet J Rare Dis. 2013 Jul 01;8:95
pubmed: 23816348
Cancer. 2006 Feb 1;106(3):609-15
pubmed: 16369986
Oncotarget. 2016 Jun 7;7(23):35412-22
pubmed: 27072578
Blood. 2010 Nov 11;116(19):3695-704
pubmed: 20671118
EMBO J. 1989 Jan;8(1):127-32
pubmed: 2540954
Cancer. 2017 Aug 15;123(16):3176-3185
pubmed: 28380259
Int J Surg Pathol. 2004 Oct;12(4):375-87
pubmed: 15494863
Am J Clin Pathol. 2008 Sep;130(3):343-51
pubmed: 18701406
J Clin Oncol. 2000 Jan;18(1):54-63
pubmed: 10623693
Blood. 2012 Oct 11;120(15):2973-80
pubmed: 22919026
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a011189
pubmed: 22952397
Leuk Lymphoma. 2015;56(12):3295-300
pubmed: 25899403
J Clin Oncol. 2014 Mar 10;32(8):798-808
pubmed: 24344220
Leuk Lymphoma. 2015 Jun;56(6):1778-86
pubmed: 25288491
J Hematol Oncol. 2018 Jan 31;11(1):15
pubmed: 29386072
Leuk Lymphoma. 2014 Sep;55(9):2048-55
pubmed: 24359240
Am J Pathol. 2008 Jul;173(1):195-204
pubmed: 18502823
Blood. 2016 May 19;127(20):2375-90
pubmed: 26980727
Blood. 1993 May 15;81(10):2688-95
pubmed: 8387835
Lancet. 2019 Jan 19;393(10168):229-240
pubmed: 30522922
Am J Surg Pathol. 2012 Apr;36(4):481-99
pubmed: 22314189
Blood Cancer J. 2014 Dec 12;4:e267
pubmed: 25501024
Blood. 1997 Jun 15;89(12):4501-13
pubmed: 9192774
Ann Hematol. 2016 Apr;95(5):847-9
pubmed: 26931114
J Clin Oncol. 2009 Dec 10;27(35):6027-32
pubmed: 19884539
Front Oncol. 2020 Sep 30;10:1723
pubmed: 33102204
Discov Med. 2017 Mar;23(126):189-199
pubmed: 28472613
J Virol. 2004 May;78(10):5194-204
pubmed: 15113901
Cancer. 1996 May 15;77(10):2137-49
pubmed: 8640683
Clin Cancer Res. 2012 Aug 1;18(15):4183-90
pubmed: 22675173
Cancer Res Treat. 2020 Apr;52(2):374-387
pubmed: 31476851
J Clin Virol. 2018 May;102:84-92
pubmed: 29525635
J Virol. 2010 May;84(9):4534-42
pubmed: 20181711
Am J Hematol. 2008 Oct;83(10):795-9
pubmed: 18756548
Blood. 2018 Nov 29;132(22):2351-2361
pubmed: 30262660
J Clin Oncol. 2016 Mar 20;34(9):963-71
pubmed: 26962200
Lancet Oncol. 2016 Mar;17(3):389-400
pubmed: 26873565
Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1115-21
pubmed: 21514070
Clin Cancer Res. 2002 Jan;8(1):29-34
pubmed: 11801537
Blood. 1988 Nov;72(5):1674-81
pubmed: 3263153
Front Immunol. 2021 Aug 06;12:708908
pubmed: 34421914
Am J Surg Pathol. 2015 Apr;39(4):462-71
pubmed: 25634749
Cancer Biol Ther. 2008 Oct;7(10):1602-6
pubmed: 18769118
Ann Hematol. 2014 Nov;93(11):1895-901
pubmed: 24947798
Cancer. 2012 Jul 1;118(13):3294-301
pubmed: 22139825
Br J Haematol. 2018 Sep;182(6):916-920
pubmed: 28771676
Eur J Immunol. 2013 Dec;43(12):3183-96
pubmed: 24030559
Am J Surg Pathol. 1996 Jan;20(1):103-11
pubmed: 8540601
Hematology. 2017 Jul;22(6):320-329
pubmed: 27917702
Clin Cancer Res. 2007 Jun 1;13(11):3250-4
pubmed: 17545530
Am J Pathol. 2001 Dec;159(6):2095-105
pubmed: 11733360
Head Neck. 2004 Jul;26(7):584-93
pubmed: 15229900