Better Estimation of Spontaneous Preterm Birth Prediction Performance through Improved Gestational Age Dating.
gestational age
gestational age dating
preterm birth
proteomic biomarker risk predictor
spontaneous preterm birth
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
19 May 2022
19 May 2022
Historique:
received:
18
04
2022
revised:
11
05
2022
accepted:
18
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
The clinical management of pregnancy and spontaneous preterm birth (sPTB) relies on estimates of gestational age (GA). Our objective was to evaluate the effect of GA dating uncertainty on the observed performance of a validated proteomic biomarker risk predictor, and then to test the generalizability of that effect in a broader range of GA at blood draw. In a secondary analysis of a prospective clinical trial (PAPR; NCT01371019), we compared two GA dating categories: both ultrasound and dating by last menstrual period (LMP) (all subjects) and excluding dating by LMP (excluding LMP). The risk predictor's performance was observed at the validated risk predictor threshold both in weeks 19
Identifiants
pubmed: 35629011
pii: jcm11102885
doi: 10.3390/jcm11102885
pmc: PMC9146613
pii:
doi:
Types de publication
Journal Article
Langues
eng
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