Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine.
3D culture
colorectal cancer
patient-derived organoids
personalized medicine
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
26 Apr 2022
26 Apr 2022
Historique:
received:
25
03
2022
revised:
22
04
2022
accepted:
24
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Colorectal cancer is one of the most important malignancies worldwide, with high incidence and mortality rates. Several studies have been conducted using two-dimensional cultured cell lines; however, these cells do not represent a study model of patient tumors very well. In recent years, advancements in three-dimensional culture methods have facilitated the establishment of patient-derived organoids, which have become indispensable for molecular biology-related studies of colorectal cancer. Patient-derived organoids are useful in both basic science and clinical practice; they can help predict the sensitivity of patients with cancer to chemotherapy and radiotherapy and provide the right treatment to the right patient. Regarding precision medicine, combining gene panel testing and organoid-based screening can increase the effectiveness of medical care. In this study, we review the development of three-dimensional culture methods and present the most recent information on the clinical application of patient-derived organoids. Moreover, we discuss the problems and future prospects of organoid-based personalized medicine.
Identifiants
pubmed: 35629118
pii: jpm12050695
doi: 10.3390/jpm12050695
pmc: PMC9147270
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20K16175
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