Characteristics of the Cardiosplenic Axis in Patients with Fatal Myocardial Infarction.
CD 68
cardiac remodeling
inflammation
myocardial infarction
spleen
splenic macrophages
stabilin-1
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
01 May 2022
01 May 2022
Historique:
received:
23
03
2022
revised:
27
04
2022
accepted:
30
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Myocardial ischemia triggers neurohumoral activation of the cardiosplenic axis. In rodents, adverse outcomes occur upon prolonged entrance of mononuclear cells from the spleen into myocardial tissue. The purpose of this study is to assess the features of spleen structure in patients with fatal myocardial infarction (MI), the dynamics of macrophage infiltration of the spleen and its relationship with cardiac macrophage infiltration and unfavorable outcomes. Using immunohistochemistry techniques, we analyzed the macrophage infiltration of the spleen and myocardium sections collected from patients (
Identifiants
pubmed: 35629341
pii: life12050673
doi: 10.3390/life12050673
pmc: PMC9147017
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Science Foundation
ID : 21-75-00025
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