The Bootstrap Model of Prebiotic Networks of Proteins and Nucleic Acids.
DNA-protein networks
origins of life
protocells
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
12 May 2022
12 May 2022
Historique:
received:
31
03
2022
revised:
08
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
It is not known how life arose from prebiotic physical chemistry. How did fruitful cell-like associations emerge from the two polymer types-informational (nucleic acids, xNAs = DNA or RNA) and functional (proteins)? Our model shows how functional networks could bootstrap from random sequence-independent initial states. For proteins, we adopt the foldamer hypothesis: through persistent nonequilibrium prebiotic syntheses, short random peptides fold and catalyze the elongation of others. The xNAs enter through random binding to the peptides, and all chains can mutate. Chains grow inside colloids that split when they're large, coupling faster growth speeds to bigger populations. Random and useless at first, these folding and binding events grow protein-xNA networks that resemble today's protein-protein networks.
Identifiants
pubmed: 35629391
pii: life12050724
doi: 10.3390/life12050724
pmc: PMC9144896
pii:
doi:
Types de publication
Journal Article
Langues
eng
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