Data Mining Identifies

biomarker cardiac hypertrophy disease model endothelin-1 stem cells transcriptomics

Journal

Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444

Informations de publication

Date de publication:
12 May 2022
Historique:
received: 20 04 2022
revised: 06 05 2022
accepted: 11 05 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 29 5 2022
Statut: epublish

Résumé

Cardiac hypertrophy is a condition that may contribute to the development of heart failure. In this study, we compare the gene-expression patterns of our in vitro stem-cell-based cardiac hypertrophy model with the gene expression of biopsies collected from hypertrophic human hearts. Twenty-five differentially expressed genes (DEGs) from both groups were identified and the expression of selected corresponding secreted proteins were validated using ELISA and Western blot. Several biomarkers, including

Identifiants

pubmed: 35629393
pii: life12050726
doi: 10.3390/life12050726
pmc: PMC9147176
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Foundation for Knowledge
ID : 20160294, 20160330, 20200014

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Auteurs

Markus Johansson (M)

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28 Skövde, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SE-413 45 Gothenburg, Sweden.

Benyapa Tangruksa (B)

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28 Skövde, Sweden.

Sepideh Heydarkhan-Hagvall (S)

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28 Skövde, Sweden.
Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, SE-413 83 Gothenburg, Sweden.

Anders Jeppsson (A)

Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.

Peter Sartipy (P)

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28 Skövde, Sweden.

Jane Synnergren (J)

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28 Skövde, Sweden.

Classifications MeSH