The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion.
GLP-1
L-cells
T2DM
enteroendocrine system
gastric bypass
glucose homeostasis
incretins
nutrient sensors
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
07 May 2022
07 May 2022
Historique:
received:
13
04
2022
revised:
03
05
2022
accepted:
05
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
The enteroendocrine system of the gut regulates energy homeostasis through the release of hormones. Of the gut-derived hormones, GLP-1 is particularly interesting, as analogs of the hormone have proven to be highly effective for the treatment of type 2 diabetes mellitus and obesity. Observations on increased levels of GLP-1 following gastric bypass surgery have enhanced the interest in endogenous hormone secretion and highlighted the potential of endogenous secretion in therapy. The macronutrients and their digestive products stimulate the secretion of GLP-1 through various mechanisms that we have only begun to understand. From findings obtained from different experimental models, we now have strong indications for a role for both Sodium-Glucose Transporter 1 (SGLT1) and the K
Identifiants
pubmed: 35629924
pii: metabo12050420
doi: 10.3390/metabo12050420
pmc: PMC9147592
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : European Research Council
ID : 695069
Pays : International
Références
Endocrinology. 2015 Mar;156(3):847-57
pubmed: 25535831
Front Endocrinol (Lausanne). 2020 Apr 03;11:178
pubmed: 32308645
J Clin Endocrinol Metab. 2003 Aug;88(8):3829-34
pubmed: 12915676
Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1358-65
pubmed: 19808907
N Engl J Med. 2021 Mar 18;384(11):989-1002
pubmed: 33567185
Nature. 1983 Jul 28-Aug 3;304(5924):368-71
pubmed: 6877358
Diabetes. 2009 May;58(5):1058-66
pubmed: 19208912
Diabetes. 2012 Jan;61(1):187-96
pubmed: 22124465
Am J Clin Nutr. 2003 Jan;77(1):91-100
pubmed: 12499328
Clin Pharmacol Ther. 2012 Jul;92(1):29-39
pubmed: 22669289
Am J Clin Nutr. 2006 Jan;83(1):89-94
pubmed: 16400055
Diabetes Obes Metab. 2017 Apr;19(4):599-603
pubmed: 27943578
Nature. 2009 May 14;459(7244):262-5
pubmed: 19329995
Endocrinology. 1995 Dec;136(12):5593-9
pubmed: 7588313
Diabetologia. 2002 Nov;45(11):1533-41
pubmed: 12436337
Diabetes. 2014 Apr;63(4):1224-33
pubmed: 24296712
Am J Physiol Endocrinol Metab. 2021 May 1;320(5):E874-E885
pubmed: 33645250
Clin Sci (Lond). 2016 Nov 1;130(22):2073-2082
pubmed: 27439969
J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17
pubmed: 21778222
Appetite. 1999 Aug;33(1):119-28
pubmed: 10447984
Diabetes. 2012 Feb;61(2):364-71
pubmed: 22190648
J Biol Chem. 1952 Nov;199(1):415-9
pubmed: 12999855
Diabetes. 2003 May;52(5):1147-54
pubmed: 12716745
Int J Obes Relat Metab Disord. 1999 Mar;23(3):304-11
pubmed: 10193877
Physiol Behav. 1998 Jun 1;64(3):279-85
pubmed: 9748094
Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G53-G65
pubmed: 29494208
Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1183-94
pubmed: 19158321
Mol Metab. 2019 Jan;19:49-64
pubmed: 30472415
Endocrinology. 1995 Aug;136(8):3585-96
pubmed: 7628397
BMC Res Notes. 2016 Feb 02;9:60
pubmed: 26830025
Surg Obes Relat Dis. 2007 Nov-Dec;3(6):597-601
pubmed: 17936091
Neurogastroenterol Motil. 2009 Sep;21(9):978-e78
pubmed: 19453518
Acta Diabetol. 1997 Mar;34(1):18-21
pubmed: 9134052
Am J Clin Nutr. 2009 Jan;89(1):106-113
pubmed: 19056578
Cell Metab. 2006 Sep;4(3):223-33
pubmed: 16950139
J Clin Endocrinol Metab. 2010 Feb;95(2):879-86
pubmed: 19837920
J Biol Chem. 1986 Sep 5;261(25):11880-9
pubmed: 3528148
Nat Cell Biol. 2018 Aug;20(8):909-916
pubmed: 30038251
Nature. 1983 Apr 21;302(5910):716-8
pubmed: 6835407
Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51
pubmed: 15607732
Proc Natl Acad Sci U S A. 1982 Jan;79(2):345-9
pubmed: 7043459
Int J Obes (Lond). 2015 Mar;39(3):424-9
pubmed: 25109781
Mol Metab. 2014 Oct 24;4(1):3-14
pubmed: 25685685
Diabetologia. 2004 Sep;47(9):1592-601
pubmed: 15365617
Regul Pept. 2012 Oct 10;178(1-3):29-35
pubmed: 22750278
Physiol Rep. 2019 Apr;7(8):e14056
pubmed: 31020803
Diabetologia. 2017 Dec;60(12):2475-2485
pubmed: 28866808
Lancet. 1987 Dec 5;2(8571):1300-4
pubmed: 2890903
J Clin Endocrinol Metab. 2008 Oct;93(10):3995-8
pubmed: 18647814
J Clin Invest. 1987 Feb;79(2):616-9
pubmed: 3543057
Endocrinology. 2012 Dec;153(12):5782-95
pubmed: 23064014
J Med Chem. 2016 Apr 28;59(8):3579-92
pubmed: 26512410
Mol Metab. 2018 Jun;12:62-75
pubmed: 29673577
J Intern Med. 2013 Mar;273(3):219-34
pubmed: 23163728
Physiol Rep. 2015 Sep;3(9):
pubmed: 26381015
Int J Obes (Lond). 2014 Oct;38(10):1365-73
pubmed: 24451185
Regul Pept. 2003 Jul 15;114(2-3):189-96
pubmed: 12832109
Am J Physiol Gastrointest Liver Physiol. 2003 May;284(5):G798-807
pubmed: 12684211
Diabetes. 2002 Sep;51(9):2757-63
pubmed: 12196469
Digestion. 1995;56(2):117-26
pubmed: 7750665
J Biol Chem. 2013 Feb 15;288(7):4513-21
pubmed: 23269670
Diabetes Obes Metab. 2016 Sep;18(9):925-9
pubmed: 27178047
Am J Clin Nutr. 1999 Jun;69(6):1135-43
pubmed: 10357731
Int J Obes Relat Metab Disord. 2001 Jun;25(6):781-92
pubmed: 11439290
J Endocrinol. 1993 Jul;138(1):159-66
pubmed: 7852887
Scand J Gastroenterol. 1995 Sep;30(9):892-6
pubmed: 8578189
Ann Oncol. 2001;12 Suppl 2:S63-8
pubmed: 11762354
J Biol Chem. 1986 Jul 25;261(21):9637-43
pubmed: 3525530
Scand J Gastroenterol. 1996 Jul;31(7):665-70
pubmed: 8819215
Am J Physiol Endocrinol Metab. 2016 Apr 1;310(7):E505-14
pubmed: 26786780
Cell Metab. 2008 Dec;8(6):532-9
pubmed: 19041768
Cell Rep. 2019 Feb 5;26(6):1399-1408.e6
pubmed: 30726726
Diabetes. 2008 Sep;57(9):2280-7
pubmed: 18519800
Sci Rep. 2017 May 24;7(1):2360
pubmed: 28539646
Endocrinology. 1986 Oct;119(4):1467-75
pubmed: 3530719
Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R524-33
pubmed: 15166004
Physiol Behav. 1979 Feb;22(2):267-73
pubmed: 441167
Diabetologia. 2013 Dec;56(12):2688-96
pubmed: 24045836
Eur J Clin Nutr. 1998 Jul;52(7):482-8
pubmed: 9683329
Endocrinology. 2011 Feb;152(2):405-13
pubmed: 21209017
Diabetes. 1998 Jul;47(7):1038-45
pubmed: 9648826
Diabetes. 2017 Aug;66(8):2144-2149
pubmed: 28385801
Surg Obes Relat Dis. 2015 Nov-Dec;11(6):1323-31
pubmed: 26048514
Nutrients. 2020 Mar 15;12(3):
pubmed: 32183423
Langenbecks Arch Surg. 2022 Mar;407(2):559-568
pubmed: 34651238
Endocrinology. 2016 Dec;157(12):4561-4569
pubmed: 27779915
Lipids. 2012 Jun;47(6):571-80
pubmed: 22297815
J Biol Chem. 1983 Mar 10;258(5):3280-4
pubmed: 6338015
Int J Obes Relat Metab Disord. 2004 Jan;28(1):57-64
pubmed: 14710168
Proc Natl Acad Sci U S A. 1987 May;84(10):3434-8
pubmed: 3033647
Int J Obes (Lond). 2017 Nov;41(11):1693-1701
pubmed: 28792489
Diabetes. 2015 Feb;64(2):370-82
pubmed: 25157092
Obesity (Silver Spring). 2018 Nov;26(11):1721-1726
pubmed: 30358156
Front Pharmacol. 2022 Jan 19;12:807548
pubmed: 35126141
FEBS Lett. 1987 Jan 26;211(2):169-74
pubmed: 3542566
J Biol Chem. 1989 Aug 5;264(22):12826-9
pubmed: 2753890
Int J Obes Relat Metab Disord. 1999 May;23(5):528-36
pubmed: 10375057
Diabetologia. 1987 Nov;30(11):874-81
pubmed: 3446554
Biochem Biophys Res Commun. 2005 Nov 4;336(4):1028-32
pubmed: 16181611